Official Symbol

UBA6provided by HGNC

Official Full Name

ubiquitin-like modifier activating enzyme 6provided by HGNC

Primary source

HGNC:25581

See related

Ensembl:ENSG00000033178; HPRD:13341; MIM:611361

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

MOP-4; UBE1L2; FLJ10808; FLJ23367; UBA6

Summary

Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 4; Location: 4q13.2See UBA6 in MapViewer

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

	1.	Ubiquitin-like modifier activating enzyme 6 activates not only ubiquitin, but also the ubiquitin-like modifier FAT10[review]
	2.	The identification of an E1-like protein, termed E1-L2, that activates both ubiquitin and another ubiquitin-like protein, FAT10, is reported.
	3.	UBE1L2 is a novel E1 enzyme specific for ubiquitin
	4.	Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s

Markers

Homology

GeneOntology Provided by GOA

Preferred Names

ubiquitin-activating enzyme E1-like 2

Names

ubiquitin-activating enzyme E1-like 2

UBA6, ubiquitin-activating enzyme E1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_018227.5→NP_060697.4 ubiquitin-activating enzyme E1-like 2

   Source sequence(s)

   AL596839,AL832015,AW451445,AY359880,BC126484,BM973988

   Consensus CDS

   CCDS3516.1

   UniProtKB/Swiss-Prot

   A0AVT1

   Conserved Domains (5) summary

   cd01490
   Location:462–777
   Blast Score:1206

   Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1)...

   cd01491
   Location:43–305
   Blast Score:971

   Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1)...

   cl00287
   Location:848–1005
   Blast Score:505
   Location:387–432
   Blast Score:172

   E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...

   TIGR01408
   Location:38–1048
   Blast Score:4502

   Ube1; ubiquitin-activating enzyme E1

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000004.11 Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

   Range

   68566889..68481479, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

2. NT_022778.16

   Range

   8777556..8692146, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000047.1 Alternate assembly (Celera)

   Range

   66029283..65943873, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

2. NW_922162.1

   Range

   15854257..15768847, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000136.1 Alternate assembly (HuRef)

   Range

   64480109..64394644, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

2. NW_001838914.1

   Range

   8781823..8696358, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

• MIM 611361
• HPRD 13341
• UCSC UCSC
• UniGene Hs.719086