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1. |
CD14(+) monocytes promote NKG2D(+)CD4(+) T cells activation through the NKG2D-MIC engagement in the pathogenesis of systemic lupus erytematosus. |
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2. |
Expression of MICA/B was detected in 97.6 of ovarian cancer cells,but not on normal ovarian epithelium. The expression of MICA/B in ovarian cancer was highly correlated with that of ULBP2. |
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3. |
Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) |
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4. |
MICB*004 allele frequency is significantly increased in multiple sclerosis patients. |
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5. |
Common MICA and MICB genetic variations are not associated with susceptibility to type 1 diabetes. |
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6. |
Elevated soluble MICB levels exist in serum of multiple sclerosis patients related with disease activity. |
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7. |
while infection with wild-type Ad enhances synthesis of the NKG2D ligands, MICA and MICB, their expression on the cell surface is actively suppressed. |
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8. |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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9. |
Observational study of genotype prevalence. (HuGE Navigator) |
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10. |
Observational study of gene-disease association. (HuGE Navigator) |
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11. |
study reports that the MICB 0050204(1) allele, present in the majority of the Spanish population (70% of healthy controls) is characterized by the presence of an extra exon found between the sequence corresponding to exon 1 and 2 |
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12. |
upregulation of MICA and MICB by treatment with TsA leads to enhancement of the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells |
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13. |
MICB protein polymorphism is implicated in human herpes virus seropositivity and schizophrenia risk. |
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14. |
variations in MICB expression among normal individuals could imply a significant difference in the natural immune response against infections or tumor transformation |
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15. |
From pairwise associations in the random panel and results for the homozygous cell lines it was possible to deduce the MICA and MICB microsatellite alleles present in many of the well-known Caucasoid |
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16. |
Circulating soluble MICB in cancer patients deactivates natural killer (NK) cell-mediated NK immunity by down-modulating important activating and chemokine receptors in vitro and in vivo. |
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17. |
In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, we have identified significant association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the MICB gene. |
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18. |
new allele is identical to MICB-0103101v except for a single mutation of G to A in exon 4 that translates into an amino acid substitution from glutamic acid to lysine |
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19. |
micb, overexpressed on a subset of human HCCs, may play an important role in their susceptibility to NK cells. |
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20. |
MICB promoter polymorphism haplotypes showed strong linkage disequilibrium with MICB alleles. |
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21. |
MICB, the second member of the human MIC protein family, is likewise shed by metalloproteases from tumor cells and is present in sera of patients with gastrointestinal tumors. |
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22. |
study shows that human cytomegalovirus-miR-UL112 specifically down-regulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells |
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23. |
Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells |
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24. |
analysis of human, chimpanzee and rhesus monkey MHC-B and MHC-C DNA gives insight to the time frame of human divergence from Old World monkeys |
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25. |
Engagement of MIC by NKG2D promotes spontaneous HAM/TSP T cell proliferation and, apparently, CTL activities against HTLV-1-infected T cells. |
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26. |
an Alu repeat dimorphism within the first intron of the MICB gene was found |
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27. |
binding of MICA and MICB induces endocytosis and downregulation of NKG2D, and in turn severe impairment of the responsiveness of tumour-antigen-specific effector T cells |
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28. |
Determination of sMICA and sMICB levels may be implemented as a prognostic parameter in patients with hematopoietic malignancies. |
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29. |
The polymorphisms and haplotype distributions of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population have their own distinct genetic characteristics |
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30. |
eight novel MICB variants, including a null allele, which were identified in peripheral blood leukocytes of gastric MALT lymphoma patients. |
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31. |
high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB*0107 N, in the Angaite Amerindian community in Paraguay |
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32. |
MICB is induced on dendritic cells upon IFN-alpha stimulation and is capable of activating NK cells by a mechanism that is impaired in hepatitis C virus infection. |
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33. |
reveal distinct modes of activation of the genes for the MIC ligands of NKG2D and provide a molecular framework for analyses of gene regulation under different cellular insult conditions |
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34. |
MICB-CA18 is positively associated with ulcerative colitis and female ulcerative colitis patients in a Chinese population. |
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35. |
NKG2D and MICB in the cytotoxic NK cell immune synapse have roles in NK cell cytotoxic function |