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1: UBA2 ubiquitin-like modifier activating enzyme 2 [ Homo sapiens ]

GeneID: 10054 updated 05-Jul-2009

[Top][Help]Summary

Official Symbol
UBA2provided by HGNC
Official Full Name
ubiquitin-like modifier activating enzyme 2provided by HGNC
Primary source
HGNC:30661
See related
Ensembl:ENSG00000126261; HPRD:11658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARX; SAE2; FLJ13058; HRIHFB2115; UBA2

[Top][Help]Genomic regions, transcripts, and products

Go to reference sequence detailsTry our new Sequence Viewer




Genomic context[Top][Help]

chromosome: 19; Location: 19q12See UBA2 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

PubMed 1. UBA2 stabilizes APOBEC3G by preventing ubiquitin chain elongation and proteasome-mediated proteolysis.
PubMed 2. structures of heterodimeric Sae1/Sae2-Mg.ATP and Sae1/Sae2-SUMO-1-Mg.ATP complexes
Submit: New GeneRIFCorrection

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_005490.1   NP_006147.1   NEDD8     HPRD   PubMed
 
  NP_005490.1   NP_005491.1   SAE1     HPRD   PubMed
SAE1 interacts with SAE2. This interaction was modeled on a demonstrated interaction between SAE1 from an unspecified species and SAE2 from an unspecified species.
  NP_005490.1   NP_005491.1   SAE1     BIND   PubMed
Sua1 interacts with hUba2.
  NP_005490.1   NP_005491.1   SAE1     BIND   PubMed
 
  NP_005490.1   NP_003343.1   SUMO1     HPRD   PubMed
SAE2 and an unspecified isoform of SUMO-1 form thioester bond. This interaction was modeled on a demonstrated interaction between SAE2 from an unspecified species and SUMO-1 from an unspecified species.
  NP_005490.1     SUMO1     BIND   PubMed
 
  NP_005490.1   SUMO3   SUMO3     HPRD   PubMed
 
  NP_005490.1   Ubiquitin       HPRD   PubMed
Two-hybrid
  BioGRID:115365   BioGRID:120586   BXDC2     BioGRID   PubMed
Reconstituted Complex
  BioGRID:115365   BioGRID:110815   NEDD8     BioGRID   PubMed
Biochemical Activity
  BioGRID:115365   BioGRID:111839   RANBP2     BioGRID   PubMed
Reconstituted Complex
  BioGRID:115365   BioGRID:112147   RPS27A     BioGRID   PubMed
Biochemical Activity
  BioGRID:115365   BioGRID:202583   Rangap1     BioGRID   PubMed
Affinity Capture-MS; Biochemical Activity; Reconstituted Complex; Two-hybrid
  BioGRID:115365   BioGRID:115366   SAE1     BioGRID   PubMed
Biochemical Activity
  BioGRID:115365   BioGRID:112555   SP100     BioGRID   PubMed
Reconstituted Complex
  BioGRID:115365   BioGRID:113188   SUMO1     BioGRID   PubMed
Affinity Capture-MS; Biochemical Activity
  BioGRID:115365   BioGRID:113177   UBE2I     BioGRID   PubMed

[Top][Help]General gene information

Markers

UBA2__5175(e-PCR)
Links: UniSTS:466542
Bdy27d05(e-PCR)
Links: UniSTS:88463
Alternate names: D19S628E; GDB:440079; RH68146
A002Q31(e-PCR)
Links: UniSTS:17818
Alternate name: RH24998

Homology

Mouse, Rat
Map Viewer

GeneOntology Provided by GOA

Function Evidence
ATP binding IEA
enzyme activator activity
PubMed 10187858		 TAS PubMed
ligase activity IEA
nucleotide binding IEA
small protein activating enzyme activity IEA
transcription factor binding IEA
Process Evidence
modification-dependent protein catabolic process IEA
protein modification process IEA
Component Evidence
nucleus IEA

[Top][Help]General protein information

Preferred Names
SUMO-1 activating enzyme subunit 2
Names
SUMO-1 activating enzyme subunit 2
SUMO1 activating enzyme subunit 2
anthracycline-associated resistance
UBA2, ubiquitin-activating enzyme E1 homolog

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_005499.2→NP_005490.1 SUMO-1 activating enzyme subunit 2

    Source sequence(s)
    AF090384,BC003153,BG503066,BG678201,BM556031,U35832
    Consensus CDS
    CCDS12439.1
    UniProtKB/Swiss-Prot
    Q9UBT2
    Conserved Domains (2) summary
    cd01489
    Location:30–200
    Blast Score:860
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
    cl00287
    Location:243–444
    Blast Score:521
    E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000019.9 Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

    Range
    34919268..34960798
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

  2. NT_011109.16

    Range
    7187486..7229016
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000062.1 Alternate assembly (Celera)

    Range
    31631712..31673210
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

  2. NW_927206.1

    Range
    7203280..7244778
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000151.1 Alternate assembly (HuRef)

    Range
    31425936..31467712
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

  2. NW_001838494.1

    Range
    37993..79769
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

Nucleotide   Protein
Genomic   AC008747.5 (26813..68343)    None
mRNA   AB015337.1   BAA34795.1
mRNA   AB208872.1   BAD92109.1
mRNA   AF079566.1   AAD23914.1
mRNA   AF090384.1   AAD12784.1
mRNA   AF110957.1   AAD24434.1
mRNA   AK023120.1   BAG51158.1
mRNA   AK024114.1   BAG51265.1
mRNA   AK124730.1   BAG54081.1
mRNA   AK299514.1   BAH13056.1
mRNA   AK315521.1   BAG37902.1
mRNA   AL136905.1   CAB66839.1
mRNA   BC003153.1   AAH03153.1
mRNA   BG503066.1    None
mRNA   BG678201.1    None
mRNA   BM556031.1    None
mRNA   BT009781.1   AAP88783.1
mRNA   CR456756.1   CAG33037.1
mRNA   U35832.1   AAC99992.1
Synthetic   DQ893423.2   ABM84349.1
Synthetic   EU176757.1   ABW03558.1
Protein Accession   Links
Q9UBT2.2   GenPept   UniProtKB/Swiss-Prot