Perfluorooctanoic acid effect on livers lacking PPAR-alpha
Summary:
Analysis of PPAR-alpha null livers from animals treated with perfluorooctanoic acid (PFOA), a member of a class of industrial chemicals called peroxisome proliferator chemicals. PFOA exposure is linked to cancer. Results provide insight into the role of PPAR-alpha in mediating the effects of PFOA.
Rosen MB, Lee JS, Ren H, Vallanat B et al. Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. Toxicol Sci 2008 May;103(1):46-56. PMID: 18281256
