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Antibiotics for treating osteomyelitis in people with sickle cell disease

Sickle cell disease affects millions of people throughout the world. Osteomyelitis, a bone infection, is one of the major complications. Antibiotics are given to treat it, but there is no worldwide standard treatment. We did an update of search randomised controlled trials which compared antibiotics (alone or in combination) with other antibiotics. We wanted to know if the different antibiotic treatments were effective, if they were safe, and which doses worked best for osteomyelitis in people with sickle cell disease. This update did not find any trials to include in this review. We conclude that a randomised controlled trial should attempt to answer these questions. There are no trials included in the review and we have not identified any relevant trials up to October 2012. We therefore do not plan to update this review until new trials are published.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Antibiotics for treating chronic bone infection in adults

Osteomyelitis is an inflammation of the bone and bone marrow caused by pus‐forming bacteria, mycobacteria or fungi. All bone infection that is long‐standing is called chronic osteomyelitis. People with this condition are treated with systemic antibiotics, which can be given by mouth or parenterally (i.e. by injection into the muscle or vein). This review is an update of our previous 2009 publication.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Antibiotics for preventing infection in open limb fractures

Wound and bone infections are common complications following open fractures of the limbs. For more than 20 years in developed countries, the use of antibiotics has been a part of a standard management protocol that also includes washing the wound (irrigation), cleaning up the wound and fracture (surgical debridement), and stabilisation of the fracture, as required. This review, which included data from 1106 participants in eight trials, found that antibiotics are effective in decreasing the incidence of wound infections, as compared with no antibiotics or placebo. No studies reporting bone infection or long‐term ill health (morbidity) were identified.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Systematic Reviews in PubMed

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