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Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropenia

More evidence is needed on the effects of granulocyte infusions for babies with sepsis and neutropenia (decreased number of white blood cells). Sepsis is an infection of the blood, caused by bacteria or fungi reaching the bloodstream. It is often fatal when it occurs in newborn babies, especially those born preterm (before 37 weeks). Preterm babies are not yet able to adequately form granulocytes, which are a key part of the immune system's ability to fight infections. Some babies with sepsis, therefore, develop neutropenia (decrease in white blood cells), which makes them more vulnerable. Granulocytes can be infused. However, the review found that there are not enough trials to show the potential benefits or harms of this treatment for newborn babies with sepsis and neutropenia.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Antifungal agents for infants and children with invasive fungal infections

Invasive fungal infections are a significant problem for children whose immune system is not functioning properly. The majority of the children have cancer. Antifungal medications can be given when these children develop a fever (for example a fever occurring when the white cells or neutrophils are low during chemotherapy) or when an infection has been formally identified (as in candidaemia, candidiasis and invasive aspergillosis). The antifungal agents that were compared appear equally efficacious. Pooling the data from the few studies that were available suggest kidney damage was less likely with a lipid preparation of amphotericin B compared with conventional amphotericin B. It is reasonable to recommend a lipid preparation of amphotericin B, if cost permits. No significant differences have been observed in children when other antifungal agents have been compared. More studies in children evaluating available antifungal are required to further clarify any benefits with regard to the risk of dying, prospects of complete recovery and drug toxicities.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

G‐CSF and GM‐CSF for treating or preventing neonatal infections

Infants born before 32 weeks and infants that are small for their gestational age are at high risk of developing infections while in hospital. These infections can cause death, disability (including cerebral palsy) as a result of damage to nervous tissue as well as contributing to chronic lung disease. Infection‐related deaths have remained constant for two decades and antibiotic resistance is increasing, emphasising the need for new ways to prevent infection.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Medical Encyclopedia

  • Neutropenia - infants
    Neutropenia is an abnormally low number of white blood cells. These cells, which are called neutrophils, help the body fight infection. This article discusses neutropenia in newborns.
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Systematic Reviews in PubMed

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