Home > Search Results

Results: 1 to 20 of 49

Scopolamine for preventing and treating motion sickness

This Cochrane Review summarises evidence from 14 randomised controlled studies evaluating the effectiveness and safety of scopolamine for motion sickness. The results show that scopolamine is more effective than placebo and scopolamine‐like derivatives in the prevention of nausea and vomiting associated with motion sickness. However, scopolamine was not shown to be superior to antihistamines and combinations of scopolamine and ephedrine. Scopolamine was less likely to cause drowsiness, blurred vision or dizziness when compared to these other agents.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Transdermal scopolamine for the prevention of postoperative nausea and vomiting: a systematic review and meta-analysis

The authors concluded that transdermal scopolamine compared with placebo was associated with significant reductions in postoperative nausea and vomiting during the first 24 hours post anaesthesia but there was a higher prevalence of visual disturbances at 24 to 48 hours after surgery. Due to the unknown quality of included studies, the reliability of the authors' conclusions is unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Scopolamine as an antidepressant: a systematic review

OBJECTIVES: The cholinergic-adrenergic hypothesis of mania and depression states that depression is characterized by an increase in central cholinergic activity relative to noradrenergic tone. Scopolamine is a centrally acting competitive inhibitor of the muscarinic cholinergic receptor site. This review seeks to find all available data investigating scopolamine as an antidepressant.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Effect of hyoscine N-butylbromide on polyp detection during colonoscopy: a meta-analysis of randomized controlled trials

Bibliographic details: Li Y, Lian JJ, Ying J, Gao J, Luo TC, Zeng XQ, Chen SY.  Effect of hyoscine N-butylbromide on polyp detection during colonoscopy: a meta-analysis of randomized controlled trials. Journal of Gastroenterology and Hepatology Research 2014; 3(9): 1220-1226 Available from: http://www.ghrnet.org/index.php/joghr/article/view/852

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Hyoscine vs glycopyrronium for drying respiratory secretions in dying patients

The author of this review concluded that there was no clear evidence to support the choice of hyoscine over glycopyrronium for drying up the secretions that cause the 'death rattle'. A thorough search identified only two relevant studies with conflicting results. The author's interpretation of the evidence was appropriate and the conclusion is likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

The effect of hyoscine N-butylbromide on adenoma detection rate: a meta-analysis of randomized clinical trials

BACKGROUND AND AIM: Anti-spasmodic drugs may facilitate mucosal inspection during colonoscopy. The impact of hyoscine N-butylbromide (HBB) on polyp detection rate (PDR) and adenoma detection rate (ADR) is unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Does hyoscine butylbromide really improve polyp detection during colonoscopy? A meta-analysis of randomized controlled trials

AIM: To investigate the benefits of hyoscine butylbromide in polyp detection during colonoscopy by a meta-analysis of available randomized controlled trials (RCTs).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Hyoscine for polyp detection during colonoscopy: a meta-analysis and systematic review

AIM: To assess the role of hyoscine for polyp detection during colonoscopy.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

The impact of hyoscine-N-butylbromide on adenoma detection during colonoscopy: meta-analysis of randomized, controlled studies

BACKGROUND: Hyoscine-N-butylbromide (HBB) can induce flattening of colon folds through inhibition of smooth muscle activity, which improves mucosal visualization. Whether this affects polyp detection is controversial.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning

This review assessed the effect of gastric lavage in acute organophosphorus pesticide poisoning. The authors concluded that there was no high quality evidence available to support the clinical effectiveness of single or multiple gastric lavages for organophosphorus pesticide poisoning. Given the methodological and reporting limitations of the primary study data, this conclusion appears appropriate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

The efficacy and safety of tiotropium in Chinese patients with stable chronic obstructive pulmonary disease: a meta-analysis

The review found that among Chinese people with stable chronic obstructive pulmonary disease, tiotropium improved pulmonary function and symptoms, reduced exacerbations and was safe. The authors’ conclusions appear reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Does tiotropium lower exacerbation and hospitalization frequency in COPD patients? Results of a meta-analysis

The authors concluded that tiotropium reduced the number of exacerbations and hospitalisations of chronic obstructive pulmonary disease (COPD) patients compared with placebo and ipratropium; compared with salmeterol, only the exacerbation frequency was reduced. Given the variability across trials, the possibility of inappropriate pooling and the poor quality of the evidence base, the authors’ conclusions should be interpreted with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials

The authors concluded that there was a 52% increased risk of mortality associated with the tiotropium mist inhaler in patients with chronic obstructive pulmonary disease . This was a well-conducted review and the conclusion is likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Comparison of tiotropium plus formoterol to tiotropium alone in stable chronic obstructive pulmonary disease: a meta-analysis

This review found that tiotropium plus formoterol significantly improved lung function and symptom scores compared with tiotropium alone in patients with stable chronic obstructive pulmonary disease. The authors recommended further research to establish long-term efficacy and safety of the combination. The conclusions reflect the evidence presented and are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis

This review concludes that adjunctive inhaled corticosteroid (ICS) and long-acting β2-agonist (LABA) therapy compared with long-acting bronchodilator monotherapy, is associated with a reduced risk of exacerbations, but an increased risk of pneumonia and oral candidiasis in patients with chronic obstructive pulmonary disease (COPD). Overall, despite some concerns, the findings of the review appear to be supported by the data presented.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Effect of tiotropium on quality of life in COPD: a systematic review

The author concluded that tiotropium improved the quality of life for patients with chronic obstructive pulmonary disease who required long-acting bronchodilator treatment. Given the unclear quality of included trials, the small number of trials and the absence of clinically significant differences for many trials, the author's conclusions should be treated with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Tiotropium and risk for fatal and nonfatal cardiovascular events in patients with chronic obstructive pulmonary disease: systematic review with meta-analysis

This review evaluated the safety of inhaled tiotropium bromide (anticholinergic agent) in patients with chronic obstructive pulmonary disease. The authors concluded that tiotropium did not significantly increase the risk of adverse major cardiovascular events compared with placebo or salmeterol. The authors' conclusions reflected the evidence presented, but lack of clarity regarding included trial quality means that their reliability is unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

This review found that inhaled anticholinergics are associated with a significantly increased risk of cardiovascular death, myocardial infarction or stroke among patients with chronic obstructive pulmonary disease. The review was generally well conducted and the authors’ conclusions appear justified.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: a systematic review

This review found that tiotropium plus a long-acting beta 2 agonist, with or without inhaled corticosteroids, appeared to be more effective than tiotropium alone for moderate-to-severe chronic obstructive pulmonary disease, but the data were scarce and follow-ups too short for firm conclusions. Overall, these conclusions appear to be suitably conservative.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Tiotropium for the treatment of stable chronic obstructive pulmonary disease: a systematic review with meta-analysis

This review concluded that the use of tiotropium was beneficial in treatment of patients with moderate-to-severe stable chronic obstructive pulmonary disease. Previous evidence in favour of the superiority of tiotropium over long-acting beta-agonists was also supported. As the results may not be generalisable and potential bias was possible, these conclusions may not be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Systematic Reviews in PubMed

See all (102)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...