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Tegaserod for the treatment of irritable bowel syndrome and chronic constipation

Irritable bowel syndrome (IBS) is a chronic, relapsing condition characterized by the presence of abdominal pain and disturbed bowel habit. Symptoms of chronic constipation frequently resemble those of constipation‐predominant IBS. Tegaserod (4 or 12 mg/day for 12 weeks), a drug that stimulates smooth muscle in the gastrointestinal tract, produces some benefit over placebo when used to treat IBS where constipation is a major symptom. Patients taking tegaserod reported an overall improvement in their IBS symptoms, an increase in number of bowel movements per day and a reduction in number of days without bowel movements. It is not clear if tegaserod improves symptoms such as abdominal pain, bloating, stool consistency and straining. When used to treat chronic constipation, the frequency of bowel movements increased with tegaserod, but increases over those seen with placebo were small. Diarrhea occurred more often among individuals taking high dose tegaserod (12 mg/day). Further studies are needed to assess the effect of tegaserod on quality of life. More information is needed on its effectiveness in men, as most of the studies involved women.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2008

Comparing Drugs for Chronic Constipation

How do the drugs used to treat chronic constipation and irritable bowel syndrome with predominant constipation compare?

PubMed Clinical Q&A [Internet] - National Center for Biotechnology Information (US).

Version: November 1, 2007

Irritable bowel syndrome: What can help?

There are a lot of treatments that aim to relieve the symptoms of irritable bowel syndrome – but not all of them have been tested in high-quality studies. Because the causes of IBS are not clear, it is difficult to find suitable treatments. But research has suggested that at least some medications and treatments may be helpful.Abdominal pain, constipation and diarrhea are the main symptoms of irritable bowel syndrome (IBS). Most people only have mild symptoms that they can cope with fairly well without treatment. Over time they learn to understand their body's signals. But sometimes the symptoms are so strong that they significantly affect people’s everyday lives and cause distress. Then several different treatment options can be considered.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: August 1, 2013

Management of faecal incontinence and constipation in adults with central nervous system diseases

Individuals with central nervous system disease or injury have a much higher risk of loss of bowel control and severe constipation than other people. This is called neurogenic bowel dysfunction (NBD). It can be very difficult to treat constipation without causing bowel leakage, or to prevent bowel leakage without causing constipation. The time spent on emptying the bowel is nearly always much greater for these individuals. Bowel problems like this cause a lot of anxiety and distress and can reduce the quality of life of those who suffer them. This review of research about NBD could be of interest to individuals with any damage to the central nervous system caused by disease or injury, or present at birth, which has a long term effect on how their bowel works.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Systematic Reviews in PubMed

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