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Treats different types of cancers, sometimes in combination with other medicines.

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Results: 12

Systematic review: effectiveness and safety of thiotepa as conditioning treatment prior to stem cell transplantation in patients with central nervous system lymphoma

Background. Thiothepa is a cytostatic agent used in managing solid malignancies, and also as conditioning treatment before hematopoietic stem cell transplantation [HSCT]. This systematic review summarizes evidence on its effectiveness and safety, in patients with central nervous system [CNS] lymphoma. Methods. We searched 3 databases for clinical studies. When feasible, we performed meta-analyses. Results. We identified 13 eligible studies, none of which with a priori controls. So data synthesis focused on the 226 patients who received thiotepa. Based on pooled estimates, 75.9% of thiotepa-treated patients achieved a complete remission (95% confidence interval [CI] = 67.5-82.8), and 61.7% had a progression-free survival for up to 125 months post-treatment (95% CI = 49.4-72.7). However, 25.5% relapsed, 24.6% experienced infection, and 13.2% experienced neurotoxicity. Discussion. Thiotepa-based conditioning followed by HSCT may be effective in most CNS lymphoma patients, with a manageable toxicity profile. But adequately powered randomized trials are needed to better evaluate and isolate the effects of thiotepa.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Drug Class Review: Newer Antiemetics: Final Report Update 1 [Internet]

Nausea and vomiting are major concerns for patients undergoing chemotherapy, radiation therapy and surgery with general anesthesia. Risk factors associated with chemotherapy-induced nausea and vomiting include emetogenicity of the chemotherapy regimen, dose, speed of intravenous infusion, female gender, age under 50 years, history of ethanol consumption, and history of prior chemotherapy. Factors predictive of radiation therapy-induced nausea and vomiting include site of irradiation (in particular, total body irradiation and radiation fields that include the abdomen), total field size, dose per fraction, age, and predisposition for emesis (history of sickness during pregnancy or motion sickness). Female gender, a history of motion sickness or prior postoperative nausea and vomiting, nonsmoking status, and use of postoperative opioids have been suggested as factors predictive of postoperative nausea and vomiting. The objective of this review was to evaluate the comparative effectiveness and harms of newer antiemetic drugs including the 5-HT3 and NK-1 antagonists.

Drug Class Reviews - Oregon Health & Science University.

Version: January 2009
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Chemotherapy for relapsed small cell lung cancer: a clinical practice guideline

This review examined the effects of chemotherapy on survival and quality of life in relapsed small cell lung cancer, concluding that the evidence is limited and insufficient to recommend a specific chemotherapy regimen in this group of patients. Because important methodological details were not reported, the conclusions should be interpreted with caution, as they may not be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Chemotherapy-induced cognitive impairment in women with breast cancer: a critique of the literature

This review investigated chemotherapy-induced cognitive impairment in women with breast cancer. The authors concluded that although the data suggest that chemotherapy-induced cognitive impairments occur, the evidence is limited and further studies are required. The authors' cautious conclusions seem appropriate. However, it is unclear whether the same results would have been obtained had a more comprehensive search strategy been used.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Ocular side effects following intravitreal injection therapy for retinoblastoma: a systematic review

This review concluded that significant ocular complications were uncommon following intravitreal injection therapy for retinoblastoma (malignant tumour of the retina), and this risk may be reduced further by the use of careful injection technique and standard dosing regimens. These conclusions appear likely to be reliable, and the review recommendations for research are appropriate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Cardiopulmonary Syndromes (PDQ®): Health Professional Version

Expert-reviewed information summary about common conditions that produce chest symptoms. The cardiopulmonary syndromes addressed in this summary are cancer-related dyspnea, malignant pleural effusion, pericardial effusion, and superior vena cava syndrome.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: October 21, 2014

Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of childhood acute lymphoblastic leukemia.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 28, 2015

Bladder Cancer Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of bladder cancer.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 9, 2015

Transitional Cell Cancer of the Renal Pelvis and Ureter Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of renal pelvis and ureter transitional cell cancer.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: March 12, 2014

Hematopoietic Stem-Cell Transplantation in the Pediatric Population [Internet]

Assess comparative benefits and harms of hematopoietic stem-cell transplantation (HSCT) versus standard therapies or disease natural history in pediatric (age ≤21 years) patients with malignant solid tumors, inherited metabolic diseases, or autoimmune diseases.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: February 2012
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Childhood Central Nervous System Embryonal Tumors Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of childhood medulloblastoma and childhood supratentorial primitive neuroectodermal and pineal tumors.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: December 11, 2014

Advanced Breast Cancer: Diagnosis and Treatment

Breast cancer is the most common cancer for women in England and Wales, with about 37,000 new cases diagnosed and 11,000 deaths recorded in England and Wales each year. In men breast cancer is rare, with about 270 cases diagnosed, and 70 deaths in England and Wales each year. Of these new cases in women and men, around 10% are diagnosed in the advanced stages, when the tumour has spread significantly within the breast or to other organs of the body. In addition, there is a significant number of women who have been previously treated with curative intent who subsequently develop either a local recurrence or metastases. Over recent years there have been important developments in the investigation and management of these patients including new chemotherapy, and biological and hormonal agents. There is some evidence of practice variation across the country and of patchy availability of certain treatments and procedures. A clinical guideline will help to address these issues and offer guidance on best practice.

NICE Clinical Guidelines - National Collaborating Centre for Cancer (UK).

Version: February 2009
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Systematic Reviews in PubMed

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