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Theophylline for the prevention of radiocontrast nephropathy: a meta-analysis

Bibliographic details: Ix J H, McCulloch C E, Chertow G M.  Theophylline for the prevention of radiocontrast nephropathy: a meta-analysis. Nephrology Dialysis Transplantation 2004; 19(11): 2747-2753

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

Comparison of leukotriene receptor antagonist and theophylline in addition to inhaled corticosteroid in adult asthma: a meta-analysis

Bibliographic details: Fang H, Wang J, Jin D, Cao Y, Xu Y, Xiong W.  Comparison of leukotriene receptor antagonist and theophylline in addition to inhaled corticosteroid in adult asthma: a meta-analysis. Biomolecules and Therapeutics 2011; 19(3): 296-301 Available from: http://tinyurl.com/cm2y6t8

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Addition of theophylline or increasing the dose of inhaled corticosteroid in symptomatic asthma: a meta-analysis of randomized controlled trials

PURPOSE: Low-dose theophylline has anti-inflammatory effects. The aim of this study was to evaluate the effects of adding theophylline compared with increasing the dose of inhaled corticosteroid (ICS) on symptomatic asthma.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Prophylactic theophylline for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia: a systematic review and meta-analysis of randomized controlled trials

OBJECTIVE: To examine the effect of prophylactic theophylline for the prevention of severe renal dysfunction in post-asphyxiated term and post-term infants.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Effect of theophylline associated with short-acting or long-acting inhaled beta2-agonists in patients with stable chronic obstructive pulmonary disease: a systematic review

OBJECTIVES: To determine whether, in stable patients with chronic obstructive pulmonary disease, administration of theophylline in combination with short-acting or long-acting inhaled beta2-agonists is more efficacious than is a placebo or each of these drugs used in isolation.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

A meta-analysis on the efficacy of oral theophylline in patients with stable COPD

The authors concluded that oral theophylline improved both trough and peak forced expiratory volume and forced vital capacity in patients with stable chronic obstructive pulmonary disease. Given the methodological limitations of the review, and the unknown quality of the included trials, the authors' conclusions may not be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Theophylline for prevention of contrast-induced nephropathy: a systematic review and meta-analysis

This review assessed the use of theophylline for the prevention of contrast-induced nephropathy. The authors concluded that current evidence appears promising but is inconclusive, and that further research is required. The results of this well-conducted review are likely to be reliable, and the authors' recommendations appear appropriate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Kinesthetic stimulation versus theophylline for apnea in preterm infants

There is some evidence that theophylline may be more effective for apnea in preterm babies than kinesthetic stimulation, but more research is needed.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2010

Effect of theophylline on prevention of contrast-induced acute kidney injury: a meta-analysis of randomized controlled trials

BACKGROUND: Whether treatment with adenosine receptor antagonists such as theophylline can prevent contrast-induced acute kidney injury (AKI) remains controversial.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Meta-analysis of efficacy and safety of oral theophylline in chronic obstructive pulmonary disease

OBJECTIVE: To evaluate the efficacy and safety of oral theophylline versus placebo in patients with stable chronic obstructive pulmonary disease (COPD).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Continuous positive airway pressure versus theophylline for apnea in preterm infants

Theophylline may be more helpful in preventing problems for preterm babies with apnea than CPAP (blowing air) through a mask. Apnea is common in preterm babies (born before 37 weeks). It is a pause in breathing of more than 20 seconds, or less than 20 seconds but with a reduced heart rate and cyanosis (a blue tinge to the skin colour indicating not enough oxygen). Resuscitation may be needed. Drugs such as theophylline can be used to stimulate breathing or continuous positive airway pressure (CPAP) which helps breathing by blowing air into the baby through a mask or tube. The review of trials found theophylline is more effective than mask CPAP for preterm infants with apnea. More research is needed.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke

Theophylline and related drugs, which can enlarge brain blood vessels, are of no apparent benefit in the early treatment of strokes caused by blood clots. Most strokes are caused by a blood clot which then reduces blood flow in the affected part of the brain. Without an adequate blood supply, the brain quickly suffers damage which is often permanent. Drugs which can improve brain blood flow might reduce damage and improve outcome after stroke. Theophylline and related drugs have the ability to alter brain blood flow. This systematic review assesses whether this type of drug improves outcome after stroke. The review identified two small trials, neither of which found any benefit. The limited amount of data mean that there is no evidence at present to suggest that theophylline and related drugs should be used in acute stroke.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Caffeine versus theophylline for apnea in preterm infants

There is some evidence that caffeine is as effective as theophylline in the short‐term for reducing apnea in premature babies, is better tolerated and is easier to give.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Oral theophylline compared to placebo for people with chronic obstructive pulmonary disease (COPD)

Theophylline treatment is commonly used in people with chronic obstructive pulmonary disease (COPD). This systematic review shows that orally administered theophylline improves lung function and levels of oxygen and carbon dioxide in the blood. However, there is limited data on its effect on symptoms, exercise capacity or quality of life. Despite being associated with increased side effects, particularly nausea, participants preferred theophylline over placebo.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

The effects of oral xanthines (e.g. theophylline) for chronic asthma in children

Xanthines (e.g. theophylline) are a group of drugs thought to have helpful preventative and reliever properties in the treatment of asthma in children. This review of studies has established that there is evidence for useful effects of these drugs in terms of symptom relief and lung function, but also some evidence of side‐effects. As a primary preventative therapy, whilst there is evidence that xanthines are effective, this review suggests that more effective alternative treatment options (inhaled steroids) are available. In children with more severe asthma, the role of xanthines as an add‐on therapy has only been assessed in a small number of trials, which report mixed effects. More studies in this area would help to generate a more reliable overview of the effects of treatment in these children. Xanthines are an effective preventative treatment in childhood asthma, but less effective than inhaled steroids, and with a less favourable side‐effect profile. There is insufficient evidence at present to assess their role as "add‐on" preventer treatment versus newer alternatives. Some of the trials exposed the children they recruited to a pre‐trial phase of xanthine in order to maintain effective dosing during the trial. This could have made the trial participants less representative of the general population by making them more inclined to tolerate the study drug. This exposure also may have meant that they could recognise what drug they were taking during the blinded phase of the study.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Long‐acting beta2‐agonists versus theophylline for maintenance treatment of asthma

This review compared three asthma medications, salmeterol, formoterol (both long acting beta‐agonists) and theophylline. These medications are used to help control symptoms of asthma, especially those which occur during the night. This review found that salmeterol showed a greater improvement in lung function, and reduced the need for extra short‐term inhalers in the day and the night. Salmeterol and formoterol are less likely to produce side‐effects (such as headaches and nausea) when compared to theophylline.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Contemporary management of chronic obstructive pulmonary disease: a scientific review

This review concluded that long-acting bronchodilators and inhaled corticosteroids reduce exacerbations in patients with moderate-to-severe chronic obstructive pulmonary disease. Supplementary oxygen therapy was associated with prolonged survival in patients with resting hypoxia. The exclusion of non-English language publications and limitations in the reporting of the review process weaken the evidence presented.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Drug Class Review: Controller Medications for Asthma: Final Update 1 Report [Internet]

To compare the efficacy and safety of inhaled corticosteroids (ICSs), long-acting beta-2 agonists (LABAs), leukotriene modifiers (LMs), anti-IgE therapy, combination products, and tiotropium for people with persistent asthma.

Drug Class Reviews - Oregon Health & Science University.

Version: April 2011
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Drug Class Review: Nasal Corticosteroids: Final Report Update 1 [Internet]

Nasal corticosteroids are a safe and effective treatment option for both allergic and non-allergic rhinitis. There are currently 8 different nasal corticosteroid preparations on the U.S. market. The nasal sprays differ with respect to delivery device and propellant, as well as potency and dosing frequency. The purpose of this review is evaluating the comparative evidence on the benefits and harms of the nasal corticosteroids to help policy makers and clinicians make informed choices.

Drug Class Reviews - Oregon Health & Science University.

Version: June 2008
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Lactose Intolerance and Health

We systematically reviewed evidence to determine lactose intolerance (LI) prevalence, bone health after dairy-exclusion diets, tolerable dose of lactose in subjects with diagnosed LI, and management.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: February 2010
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Medical Encyclopedia

  • Aminophylline overdose
    Aminophylline or theophylline are medicines used to prevent and treat wheezing and other breathing difficulties caused lung diseases such as asthma.
  • Drug Class Review: Newer Antihistamines: Final Report Update 2 [Internet]
    Antihistamines inhibit the effects of histamine at H1 receptors. They have a number of clinical indications including allergic conditions (e.g., rhinitis, dermatoses, atopic dermatitis, contact dermatitis, allergic conjunctivitis, hypersensitivity reactions to drugs, mild transfusion reactions, and urticaria), chronic idiopathic urticaria (CIU), motion sickness, vertigo, and insomnia.
  • Drug-induced tremor
    Drug-induced tremor is involuntary shaking due to the use of medication. Involuntary means you shake without trying to do so. The shaking occurs when you move or try to hold your arms, hands, or head in a certain position. It is not associated with other symptoms.
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