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Rifampicin plus pyrazinamide versus isoniazid for treating latent tuberculosis infection: a meta-analysis

This well-conducted review compared the efficacy and safety of rifampicin plus pyrazinamide (RZ) with isoniazid for the treatment of latent tuberculosis infection in HIV-positive and HIV-negative individuals. The authors concluded that both regimens were effective and that mortality was equivalent. However, in HIV-negative patients, RZ groups experienced more adverse events. This conclusion should be treated with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Standardized treatment of active tuberculosis in patients with previous treatment and/or with mono-resistance to isoniazid: a systematic review and meta-analysis

This review assessed outcomes related to treatment failure in tuberculosis patients who had been previously treated or who had documented isoniazid mono-resistance. The authors concluded that there was little published evidence to support the continued use of the currently recommended regimen for the treatment of these patient groups. This conclusion is probably reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Effect of duration and intermittency of rifampin on tuberculosis treatment outcomes: a systematic review and meta-analysis

This review concluded that treatment outcomes of tuberculosis treatment were significantly worse with shorter durations of rifampin. Treatment outcomes were similar across the different intermittent schedules evaluated but there was insufficient evidence for administration twice weekly throughout treatment. These conclusions reflected the results of the included trials, which included large numbers of patients, and appear likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Systematic review, meta-analysis and economic modelling of molecular diagnostic tests for antibiotic resistance in tuberculosis

The study found that rapid molecular tests for rifampicin and isoniazid resistance resistance in tuberculosis were sensitive and specific, and may be cost-effective when added to culture drug susceptibility testing in the UK.

Health Technology Assessment - NIHR Journals Library.

Version: May 2015
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Effectiveness of standard short-course chemotherapy for treating tuberculosis and the impact of drug resistance on its outcome

This well-conducted review assessed standard short-course chemotherapy for patients with tuberculosis. The author concluded that the target cure rate of 85% is not achievable using an intermittent regimen, and that the World Health Organization directly observed treatment short-course-plus multi-drug resistant programme should be adopted. These conclusions are not supported by the results of the review, as they were not directly assessed.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Home Isolation to Prevent Tuberculosis Transmission: A Review of the Clinical Evidence and Guidelines [Internet]

The purpose of this report is to assess the literature reporting on home (versus hospital) isolation of individuals with active tuberculosis (TB) including the guidance contained in relevant evidence-based clinical practice guidelines (CPGs).

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: May 5, 2014
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Intermittent or daily short course chemotherapy for tuberculosis in children: meta-analysis of randomized controlled trials

This review concluded that twice weekly intermittent short course therapy was less likely to cure tuberculosis in children compared with daily therapy. This conclusion should be interpreted with some caution, as it is based on the per-protocol rather than the intention-to-treat analysis, and the included trials were small and of generally poor quality.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Diagnostic accuracy and reproducibility of WHO-endorsed phenotypic drug susceptibility testing methods for first-line and second-line antituberculosis drugs

In an effort to update and clarify policies on tuberculosis drug susceptibility testing (DST), the World Health Organization (WHO) commissioned a systematic review evaluating WHO-endorsed diagnostic tests. We report the results of this systematic review and meta-analysis of the diagnostic accuracy and reproducibility of phenotypic DST for first-line and second-line antituberculosis drugs. This review provides support for recommended critical concentrations for isoniazid and rifampin in commercial broth-based systems. Further studies are needed to evaluate critical concentrations for ethambutol and streptomycin that accurately detect susceptibility to these drugs. Evidence is limited on the performance of DST for pyrazinamide and second-line drugs.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Fixed-dose combination antituberculosis therapy: a systematic review and meta-analysis

The authors concluded that although fixed-dose combination formulations simplified tuberculosis therapy, the current evidence did not indicate that these formulations improved treatment outcomes among patients with active tuberculosis. The authors conclusions reflect the evidence presented and are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

A systematic review of the adjunctive use of systemic corticosteroids for pulmonary tuberculosis

This review assessed adjunctive systemic corticosteroids in the treatment of pulmonary tuberculosis (PTB). The authors concluded that adjunctive systemic corticosteroids can safely provide significant clinical and radiologic benefits for selected patients with advanced PTB. Since most of the included studies were conducted over 20 years ago, the relevance of the results to current practice is unknown.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Systematic Reviews in PubMed

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