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About - Oxybutynin

Absorbed through the skin: Treats overactive bladder.

By mouth: Treats an overactive bladder, such as incontinence (loss of bladder control) or a frequent need to urinate by helping you have more control over the need to urinate. Also treats children 6 years of age and older with an overactive bladder caused by certain nerve disorders (such as spina bifida).

UsesSide effectsLatest evidence reviewsResearch summaries for consumersBrand names

Results: 21 to 34 of 34

A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs

BACKGROUND: Mild cognitive deficits are experienced by 18% of community-dwelling older adults, many of whom do not progress to dementia. The effect of commonly used medication on subtle impairments in cognitive function may be under-recognized.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Timed voiding for the management of urinary incontinence in adults

This review examined the use of a fixed interval of voiding for the management of urinary incontinence in adults. This approach to urinary incontinence is thought to be common in aged care homes for people who require assistance from other people for toileting and continence care. The reviewers found two trials that had evaluated timed voiding. They included 298 elderly women who were living in aged care homes and had reduced cognition and impaired mobility. Reductions in the number of incontinence episodes were reported in each trial. The reviewers found insufficient data for these findings to be combined. Hence, at this point in time, there is not enough evidence on the effects of timed voiding for the management of urinary incontinence.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Treatment of overactive bladder in women

The authors concluded that the evidence did not allow definitive conclusions on the relative benefit and harm of different treatments to achieve similar results. High-quality research was imperative to provide women and their care providers with better information to guide their choices. This was generally a well-conducted piece of research and the authors? cautious conclusions seem appropriate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Anticholinergic drugs in patients with overactive bladder syndrome.

An overactive bladder is a condition in which bladder contracts suddenly without any control, resulting in feeling to urinate and or leakage of urine. This is a common condition in adults and is also called as 'irritable' bladder or detrusor instability, urge or urgency‐frequency syndrome. Overactive bladder becomes more common with advancing age. Anticholinergic drugs mainly by their muscle relaxant action can help adults with symptoms of urinary frequency, urgency and urge incontinence.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Naftopidil for the treatment of benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH) can cause bothersome lower urinary tract symptoms such as increased frequency, urgency, night‐time urinations, straining and hesitancy. BPH is common in older males and its symptoms can affect quality of life. This review of eight trials evaluated naftopidil for the treatment of BPH. Current evidence is sparse. We did not identify any placebo‐controlled trials. Naftopidil had a similar short‐term efficacy and adverse‐effect profile compared to low‐dose tamsulosin, and better efficacy than phytotherapy (eviprostat). Adverse effects of naftopidil were few, most commonly dizziness and hypotension. Prior to wide‐spread use, more long‐term, randomized, controlled studies compared to standard therapy are needed.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Bladder training for urinary incontinence in adults

Urinary incontinence is the inability to control the leakage of urine and is a common and distressing problem. Urge incontinence is leakage of urine when a person is unable to control the strong desire to pass urine (void). Stress incontinence is the leakage of urine when a person coughs or undertakes physical exertion. Bladder training encourages people to extend the time between voiding so that continence might be regained. This can take months to achieve but may help people who are physically and mentally able to use this method. The review of trials did not find enough rigorous evidence and concluded that more research is needed. The limited evidence available suggests that bladder training may be helpful in treating urinary incontinence but this is not definite.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Traditional sling operations for urinary incontinence in women

Traditional sling operations are used to treat women with stress urinary incontinence. This is loss of urine when coughing, laughing, sneezing or exercising due to damage to the muscles that hold up the bladder, and injuries to the nerves that may occur during childbirth. Sometimes stress incontinence occurs together with "urge incontinence" ‐ known as "mixed incontinence". The sling operation aims to hold up the bladder with a strip of material which may be biological or synthetic. The results showed that there is not enough information on which to judge whether traditional sling operations are better or worse than any other treatments. Long term results are awaited. In this review there were few trials, of high quality, comparing slings with other forms of surgery and only one study comparing sling operations with non‐surgical treatment.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Pelvic floor muscle training added to another active treatment versus the same active treatment alone for urinary incontinence in women

Involuntary leakage of urine (urinary incontinence) affects women of all ages, particularly older women who live in residential care such as nursing homes. Some women leak urine during exercise or when they cough or sneeze (stress urinary incontinence) and this may occur as a result of weakness of the pelvic floor muscles such as damage during childbirth. Other women leak urine before going to the toilet when there is a sudden and compelling need to pass urine (urgency urinary incontinence) and this may be caused by involuntary contraction of the bladder muscle. Mixed urinary incontinence is the combination of both stress and urgency urinary incontinence. Pelvic floor muscle training is a supervised treatment and it involves muscle‐clenching exercises to strengthen the pelvic floor muscles. It is a common treatment used by women to stop urine leakage. Other treatments are also available which can either be used alone or in combination with pelvic floor muscle training.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Overactive bladder: What helps women who have the urge to urinate very frequently?

Bladder training and pelvic floor muscle exercises can reduce leaks and visits to the toilet in women with an overactive bladder. Medication can also help a little. Surgery for this condition has not been studied enough.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: February 2, 2012

The Management of Lower Urinary Tract Symptoms in Men [Internet]

The guideline covers men (18 and over) with a clinical working diagnosis of lower urinary tract symptoms (LUTS). Options for conservative, pharmacological, surgical, and complementary or alternative treatments are considered in terms of clinical and cost effectiveness.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: 2010
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Multiple Sclerosis: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care

Multiple sclerosis (MS) is a condition of the central nervous system (brain and spinal cord) that usually starts in early adult life. Once present the disease never goes; there is no cure and the person lives with the condition for life but a significant proportion of people have few or no problems. The impact of MS on the individual is variable but one constant feature is uncertainty. The condition also has an impact on family members.

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK).

Version: 2004
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Urinary Tract Infection in Children: Diagnosis, Treatment and Long-term Management

In the past 30–50 years, the natural history of urinary tract infection (UTI) in children has changed as a result of the introduction of antibiotics and improvements in health care. This change has contributed to uncertainty about the most appropriate and effective way to diagnose and treat UTI in children and whether or not investigations and follow-up are justified.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: August 2007
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Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care

It is almost 200 years since James Parkinson described the major symptoms of the disease that came to bear his name. Slowly but surely our understanding of the disease has improved and effective treatment has been developed, but Parkinson’s disease remains a huge challenge to those who suffer from it and to those involved in its management. In addition to the difficulties common to other disabling neurological conditions, the management of Parkinson’s disease must take into account the fact that the mainstay of pharmacological treatment, levodopa, can eventually produce dyskinesia and motor fluctuation. Furthermore, there are a number of agents besides levodopa that can help parkinsonian symptoms, and there is the enticing but unconfirmed prospect that other treatments might protect against worsening neurological disability. Thus, a considerable degree of judgement is required in tailoring individual therapy and in timing treatment initiation. It is hoped that this guideline on Parkinson’s disease will be of considerable help to those involved at all levels in these difficult management decisions. The guideline has been produced using standard NICE methodology and is therefore based on a thorough search for best evidence.

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK).

Version: 2006
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Depression in Adults with a Chronic Physical Health Problem: Treatment and Management

This clinical guideline was commissioned by NICE and developed by the National Collaborating Centre for Mental Health. It sets out clear, evidenceand consensus-based recommendations for healthcare staff on how to treat and manage depression in adults with a chronic physical health problem.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2010
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Systematic Reviews in PubMed

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