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Results: 12

Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials

OBJECTIVE: To evaluate the comparative efficacy and tolerability of naratriptan in the treatment of acute attacks of migraine.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

Migraine: Are there differences in how the triptans work?

Drugs known as triptans can relieve migraine symptoms. There are differences between the various triptans, such as how they are used. It is hard to tell whether some triptans work better or have fewer side effects than others.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: June 20, 2012

Comparing Triptans

How do triptans compare in treating migraines?

PubMed Clinical Q&A [Internet] - National Center for Biotechnology Information (US).

Version: October 1, 2010

Treating migraine with medication

Migraine attacks can be treated with different types of medication. Apart from commonly used painkillers, products for nausea or special migraine medication called triptans can also be used.Most people will use one or more medications to help them through an attack, especially if the migraine is very painful. Which medications people use depends on how serious the migraine attack is: A "basic" painkiller from a pharmacy might be enough to relieve moderate pain. But a stronger medication is needed for more severe migraines. People who have frequent migraines will often keep a variety of medications ready to be used if needed.The types of medication most commonly used by adults with migraines are:Painkillers from the group of non-steroidal anti-inflammatory drugs (NSAIDs) such as acetylsalicylic acid (ASA, the drug in "Aspirin"), ibuprofen, diclofenac or naproxen, and acetaminophen (paracetamol)Nausea medication like metoclopramide or domperidoneSpecial migraine medication (triptans) such as almotriptan or eletriptanAnother substance some migraine prescription drugs are based on  is ergotamine, which is derived from a grain fungus called ergot. For almost a century this was the only medicine specifically used to treat migraines. Nowadays, ergotamine is used less because it has more side effects than the triptans. In Germany, ergotamine products are no longer approved for preventing migraines as of 2014.Different types of medication serve different purposes. Some people mainly want relief as quickly as possible. They might go for a drug that acts faster, even if another might provide more relief but take longer to kick in. For others, maximum relief is the most important thing, even if it takes a little longer to start working. People whose migraines last for a long time might prefer drugs with a longer-lasting effect. Some people's options are limited, for example because they have heart disease and are therefore advised not to use triptans.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: June 20, 2012

Drug Class Review: Triptans: Final Report Update 4 [Internet]

Triptans, also called serotonin 5-hydroxytryptamine (5-HT)(1B/1D) agonists, are used to treat migraine and certain other headaches. Triptans act by binding to serotonin receptors in the brain, which leads to a reversal of blood vessel swelling. Triptans may be taken subcutaneously, orally as tablets, capsules, or quick-dissolving wafers, or intranasally as a spray. Currently, 7 triptans are available in the United States (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan), as well as a fixed-dose combination product containing sumatriptan plus naproxen. Comparing the clinical efficacy and harms of the different triptans has been an area of considerable interest to researchers and patients, but is complex because of the large variety of outcome measures that can be measured in studies. The purpose of this review is to compare the efficacy, effectiveness, and harms of triptans.

Drug Class Reviews - Oregon Health & Science University.

Version: June 2009
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Naproxen for acute migraine in adults

Migraine is a complex condition with a wide variety of symptoms. For many people the main feature is a painful headache. Other symptoms include feeling sick, vomiting, disturbed vision, and sensitivity to light, sound, and smells.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Self-Harm: Longer-Term Management

This is the first NICE guideline on the longer-term management of both single and recurrent episodes of self-harm.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2012
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Migraine in Children: Preventive Pharmacologic Treatments [Internet]

To assess the comparative effectiveness and safety of preventive pharmacologic treatments for community-dwelling children with episodic or chronic migraine.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: June 2013
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Meta-analysis of the efficacy and safety of zolmitriptan in the acute treatment of migraine

The authors concluded that zolmitriptan 2.5mg tablet was effective for acute migraine with similar efficacy to almotriptan 12.5mg, eletriptan 40mg and sumatriptan 50mg and greater efficacy than naratriptan 2.5mg for pain-free response at two hours. Findings that were based predominantly on single studies and incomplete reporting of review methods made it difficult to assess the reliability of the conclusions.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Acute treatment and prevention of menstrually related migraine headache: evidence-based review

This review found evidence to support the use of a number of medications in the acute treatment and short-term prevention of menstrually related migraine. Overall the review was well conducted, but the authors' specific recommendations for particular treatment regimes, especially where based on more limited evidence, should be treated with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Triptans in prevention of menstrual migraine: a systematic review with meta-analysis

The authors concluded that triptans were an effective short-term prophylactic treatment for menstrual migraines. Considering migraine frequency, severity and adverse events, frovatriptan 2.5mg twice daily and zolmitriptan 2.5mg three times daily were the most preferable regimens. The conclusion regarding the effectiveness of triptans seems reliable; the recommendations for further research were justified.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Meta-analysis of the efficacy and safety of naproxen sodium in the acute treatment of migraine

This review concluded that naproxen sodium was more effective than placebo, but might produce more adverse events, in the acute treatment of moderate or severe migraine attacks in adults. Trials were needed to compare it with other active treatments. These conclusions reflect the results, but the small number of trials and omission of the trial selection process should be considered.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Systematic Reviews in PubMed

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