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Used as a part of a process for cleaning waste out of your body when your kidneys do not work correctly. This medicine is a peritoneal dialysis solution.

UsesSide effectsLatest evidence reviewsResearch summaries for consumersBrand names

Results: 6

A meta-analysis of the use of 4 % icodextrin solution to prevent adhesion formation after gynaecological surgery

Bibliographic details: MacKie FL, Dias S, Watson A, Ahmad G.  A meta-analysis of the use of 4 % icodextrin solution to prevent adhesion formation after gynaecological surgery. Gynecological Surgery 2013; 10(1): 5-10

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Comparison of icodextrin and glucose solutions for long dwell exchange in peritoneal dialysis: a meta-analysis of randomized controlled trials

The authors cautiously suggested that, for patients undergoing long-dwell exchange in peritoneal dialysis, icodextrin provided greater fluid removal and small-solute clearance, did not cause damage to residual kidney function and was particularly appropriate for use in patients with high peritoneal transport status. This conclusion reflects the evidence presented and seems reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Impact of icodextrin on clinical outcomes in peritoneal dialysis: a systematic review of randomized controlled trials

BACKGROUND: Although icodextrin has been shown to augment peritoneal ultrafiltration in peritoneal dialysis (PD) patients, its impact upon other clinical end points, such as technique survival, remains uncertain. This systematic review evaluated the effect of icodextrin use on patient level clinical outcomes.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Biocompatible dialysis fluids for peritoneal dialysis

Peritoneal dialysis (PD) is a form of treatment for people with advanced kidney disease to an extent where their own kidney function is inadequate to meet the body's requirements. PD is flexible, and allows for therapy to be instituted by patients at home. After initial surgical insertion of a catheter into the abdomen, patients are required to perform regular exchange of PD solution at a prescribed rate to allow clearance of toxins and fluids across the peritoneal membrane. Unfortunately, the longevity of PD is limited, which is largely due to peritoneal membrane injury that results from the use of biologically 'unfriendly' PD solutions. The 'unfriendly' characteristics of these solutions include high glucose levels, glucose breakdown products and acidity. To overcome these hurdles, biocompatible PD solutions (i.e. neutral pH, lowered levels of glucose breakdown products, use of materials alternative to glucose such as icodextrin) have been manufactured that are designed to cause less damage to the peritoneal membrane. This review of interventions testing the benefits and harms of biocompatible PD solutions identified 36 studies (2719 patients).

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis

This review assessed the benefits and harms of four adhesion barriers for abdominal surgery and concluded that evidence suggests that oxidised regenerated cellulose and hyaluronate carboxymethyl cellulose reduce adhesion formation. This was a well conducted review but the evidence base was limited in size and by heterogeneity, which means that the reliability of the findings is unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Laparoscopic management of endometriosis: comprehensive review of best evidence

The authors found that laparoscopic treatment of endometriosis reduced pain and improved fertility. Co-interventions that may help (in appropriate circumstances) included laparoscopic presacral neurectomy, pre-operative and/or postoperative hormonal suppression, excisional cystectomy with mesna and/or initial circular excision and anti-adhesive barriers. Due to methodological problems in the review, particularly the failure to assess study quality, the conclusions should be regarded cautiously.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Systematic Reviews in PubMed

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