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Results: 17

Arthritis: What can prevent stomach ulcers caused by painkillers and who needs such protection?

Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac or ibuprofen can cause ulcers in the stomach and intestine. But the risk can be significantly reduced by taking particular medications.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: April 26, 2012

Comparing NSAIDs

How do NSAIDs compare in reducing pain?

PubMed Clinical Q&A [Internet] - National Center for Biotechnology Information (US).

Version: May 1, 2011

Osteoarthritis: National Clinical Guideline for Care and Management in Adults

This guideline applies to people with a working diagnosis of osteoarthritis who present for treatment or whose activities of daily living are significantly affected by their osteoarthritis. The management of neck or back pain related to degenerative changes in spine are not part of this guideline.

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK).

Version: 2008
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Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs): Final Update 4 Report [Internet]

We compared the effectiveness and harms of oral or topical nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of chronic pain from osteoarthritis, rheumatoid arthritis, soft tissue pain, back pain, and ankylosing spondylitis.

Drug Class Reviews - Oregon Health & Science University.

Version: November 2010
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Heavy Menstrual Bleeding

Heavy menstrual bleeding (HMB) has an adverse effect on the quality of life of many women. It is not a problem associated with significant mortality. Many women seek help from their general practitioners and it is a common reason for referral into secondary care.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: January 2007
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Drug Class Review: Proton Pump Inhibitors: Final Report Update 5 [Internet]

Proton pump inhibitors decrease secretion of gastric acid. They act by blocking the last enzyme in the system that actively transports acid from gastric parietal cells into the gastrointestinal lumen, hydrogen–potassium adenosine triphosphatase, also known as the proton pump. Omeprazole, the first drug in this class, was introduced in 1989. Since then, 4 other proton pump inhibitors have been introduced: lansoprazole (1995), rabeprazole (1999), pantoprazole (2000), and esomeprazole (2001). In 2003 omeprazole became available over-the-counter in the United States. The purpose of this review is to compare the benefits and harms of different PPIs.

Drug Class Reviews - Oregon Health & Science University.

Version: May 2009
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Lactose Intolerance and Health

We systematically reviewed evidence to determine lactose intolerance (LI) prevalence, bone health after dairy-exclusion diets, tolerable dose of lactose in subjects with diagnosed LI, and management.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: February 2010
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Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet]

To update a previous report on the comparative benefits and harms of oral non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen, over-the-counter supplements (chondroitin and glucosamine), and topical agents (NSAIDs and rubefacients, including capsaicin) for osteoarthritis.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: October 2011
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Pain control in first-trimester and second-trimester medical termination of pregnancy: a systematic review

BACKGROUND: Pain is a predictable feature of medical abortion in both the first trimester and the second trimester. We sought to evaluate optimal analgesia regimens during medical abortion.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Analgesics for Osteoarthritis

As an update to a 2006 report, a systematic review of 273 clinical studies published between January 2005 and January 2011 examined the comparative effectiveness, benefits, and adverse effects of analgesics and the supplements glucosamine and chondroitin for osteoarthritis. The review did not include studies on opioid medications or nonpharmacological interventions for osteoarthritis. The full report, listing all studies, is available at www.effectivehealthcare.ahrq.gov/analgesicsupdate.cfm. This summary, based on the full report of research evidence, is provided to inform discussions with patients of options and to assist in decisionmaking along with a patient's values and preferences. However, reviews of evidence should not be construed to represent clinical recommendations or guidelines.

Comparative Effectiveness Review Summary Guides for Clinicians [Internet] - Agency for Healthcare Research and Quality (US).

Version: February 15, 2012

Intrapartum Care: Care of Healthy Women and Their Babies During Childbirth

This guideline covers the care of healthy women in labour at term (37–42 weeks of gestation). About 600 000 women give birth in England and Wales each year, of whom about 40% are having their first baby. Most of these women are healthy and have a straightforward pregnancy. Almost 90% of women will give birth to a single baby after 37 weeks of pregnancy with the baby presenting head first. Most women (about two-thirds) go into labour spontaneously. Thus the majority of women giving birth in the UK fall under the scope of this guideline.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: September 2007
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Use of Aspirin and NSAIDs to Prevent Colorectal Cancer [Internet]

The purpose of this report was to systematically review the literature on the effectiveness of aspirin (ASA), non-aspirin nonsteroidal anit-inflammatory drugs (non-ASA NSAIDs), and cyclooxygenase-2 inhibitors (COX-2 inhibitors) for the chemoprevention of colorectal cancer (CRC) and CRC-related mortality in average-risk individuals. The review also assessed the harms associated with the use of these agents and their cost effectiveness.

Evidence Syntheses - Agency for Healthcare Research and Quality (US).

Version: March 2007
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Rheumatoid Arthritis: National Clinical Guideline for Management and Treatment in Adults

There are over 400,000 people with rheumatoid arthritis (RA) in the UK. Although this makes it a common disorder, there are numerous other conditions ahead of it in terms of numbers, and indeed as causes of excess mortality. What this does not capture however, is the dreadful morbidity associated with the disease. The synovitis of RA affects multiple sites causing widespread pain, and the subsequent destruction of the joints can lead to severe disability affecting all aspects of motor function from walking to fine movements of the hand. Furthermore, RA is not simply a disease of the joints but can affect many other organs causing, for example, widespread vasculitis or severe lung fibrosis. More recently it has become apparent that RA is associated with an increased prevalence of coronary artery disease and significant increased risk of premature mortality.

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK).

Version: February 2009
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Dyspepsia: Managing Dyspepsia in Adults in Primary Care

This national guideline provides evidence-based recommendations for the primary care management of dyspepsia symptoms and underlying causes in adults. It was developed for use by the National Health Service in England and Wales. NHS healthcare professionals, patient representatives and researchers developed this guideline, incorporating comments received from referees and from an extensive national stakeholder consultation.

NICE Clinical Guidelines - North of England Dyspepsia Guideline Development Group (UK).

Version: August 1, 2004
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Caesarean Section

This guidance is a partial update of NICE clinical guideline 13 (published April 2004) and will replace it.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: November 2011

Screening for Dementia [Internet]

To produce an evidence-based review to support recommendations from the US Preventive Services Task Force (USPSTF) concerning dementia syndrome screening in primary care settings.

Systematic Evidence Reviews - Agency for Healthcare Research and Quality (US).

Version: June 2003
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Pain (PDQ®): Health Professional Version

Expert-reviewed information summary about pain as a complication of cancer or its treatment. Approaches to the management and treatment of cancer-associated pain are discussed.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 30, 2014

Systematic Reviews in PubMed

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