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About - Cyclosporine

By mouth: Prevents organ rejection after a transplant. Also treats rheumatoid arthritis and psoriasis.

Injection: Helps prevent organ rejection after transplant surgery.

Into the eye: Treats chronic dry eye.

UsesSide effectsLatest evidence reviewsResearch summaries for consumersBrand names

Results: 41 to 60 of 119

Mycophenolate mofetil decreases acute rejection and may improve graft survival in renal transplant recipients when compared with azathioprine: a systematic review

This review concluded that mycophenolate mofetil used with a calcineurin inhibitor conferred a clinical benefit over azathioprine by reducing the risk of acute rejections and possibly reducing graft loss in patients receiving kidney transplants. This was a well-conducted review, but these conclusions should be treated cautiously given the poor quality of most of the evidence.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Stem cell transplantation of sibling donors compared with specific immunosuppressive therapy for acquired severe aplastic anemia

Acquired severe aplastic anemia is rare. Stem cells from the bone marrow usually replace naturally dying blood cells in the peripheral blood. Severe aplastic anemia is probably caused by an irregular, attacking immune response against these blood producing stem cells within the body. If supplies are not maintained, functional blood cells are lacking and infections, bleeding, and exhaustion will occur. Patients may experience paleness, weakness, fatigue, and shortness of breath. Disease progression is associated with severe infections, which are a major cause of death.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

[Meta-analysis of calcineurin inhibitor in the treatment of lupus nephritis]

OBJECTIVE: To systematically evaluate the clinical effects of cyclosporine A (CsA) and tacrolimus, which are calcineurin inhibitors, on lupus nephritis.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

INTRODUCTION: Acquired severe aplastic anemia (SAA) is a rare and progressive disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells is a first-line treatment option if HLA-matched related donors are available. First-line immunosuppressive therapy may be offered as alternative. The aim was to compare the outcome of these patients in controlled trials.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Clinical and cost-effectiveness of newer immunosuppressive regimens in renal transplantation: a systematic review and modelling study

OBJECTIVES: To examine the clinical effectiveness and cost-effectiveness of the newer immunosuppressive drugs for renal transplantation: basiliximab, daclizumab, tacrolimus, mycophenolate (mofetil and sodium) and sirolimus.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Terbinafine in the treatment of onychomycosis: a review of its efficacy in high-risk populations and in patients with nondermatophyte infections

BACKGROUND: The prevalence of onychomycosis is higher in certain high-risk populations, such as the immunocompromised, diabetics and human immunodeficiency virus (HIV)-positive patients. These patients can also develop onychomycosis due to nondermatophyte fungi. Although the efficacy of terbinafine is well demonstrated in the treatment of conventional dermatophyte nail infection, there are few data on the efficacy of terbinafine in high-risk patient groups or in nondermatophyte fungi, which can be difficult to treat.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

Clinical and cost-effectiveness of newer immunosuppressive regimens in renal transplantation: a systematic review and modelling study

Kidney transplantation is the treatment of choice for end-stage renal disease because, if successful, it achieves better quality and duration of life than with long-term dialysis. Approximately 1400 renal transplants are performed in England and Wales each year (1700 in the UK). A variety of immunosuppressive drugs is used in the management of renal transplants in the UK.

NIHR Health Technology Assessment programme: Executive Summaries - NIHR Evaluation, Trials and Studies Coordinating Centre (UK).

Version: 2005

A systematic review and economic model of the clinical and cost-effectiveness of immunosuppressive therapy for renal transplantation in children

The prevalence of end-stage renal failure in the UK paediatric population varies from 13.6 per million in the under 4-year-old population to 53.4 per million in the under 18-year-old population. Renal transplantation has established itself as the optimum treatment for end-stage renal failure. The goal of immunosuppression is to maintain graft and patient survival without exposing the patient to the risks of excessive immunosuppression or nephrotoxicity related to the use of immunosuppressant drugs. The current mainstay of therapy in children in the UK is a triple immunosuppression consisting of a calcineurin inhibitor (ciclosporin or tacrolimus), a DNA proliferation inhibitor (usually azathioprine) and steroids.

NIHR Health Technology Assessment programme: Executive Summaries - NIHR Evaluation, Trials and Studies Coordinating Centre (UK).

Version: 2006

Tumor necrosis factor alpha blocking agents as treatment for ulcerative colitis intolerant or refractory to conventional medical therapy: a meta-analysis

BACKGROUND: Efficacy of tumor necrosis factor alpha (TNF-α) blockers for treatment of ulcerative colitis that is unresponsive to conventional therapy is unclear due to recent studies yielding conflicting results.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Interventions for Rosacea

Rosacea is a common skin condition causing flushing, redness, red pimples, and pustules on the face, which should not be confused with acne. It can also cause inflammation of the eyes or eyelids, or both. Some people can develop a thickening of the skin, especially of the nose, which is called rhinophyma. Because rosacea is a chronic disease the effect of treatment on quality of life is very important to the individual. A range of treatment options are available which include several topical and oral antibiotics, azelaic cream, topical and systemic retinoids, and light‐based therapies, e.g. laser therapy.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Treatments for nail psoriasis

Psoriasis is a common chronic skin disease with a prevalence in 2% to 3% of the population, according to European studies. Involvement of the nails occurs in about 50%. Nail psoriasis is difficult to treat, but may respond to some treatments. We aimed to review the efficacy and safety of the treatments used for nail psoriasis.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Balneotherapy or spa‐therapy for Rheumatoid Arthritis

This summary of a Cochrane review presents what we know from research about the effect of Balneotherapy for Rheumatoid Arthritis (RA).

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2008

An update on the impact of pre-transplant transfusions and allosensitization on time to renal transplant and on allograft survival

BACKGROUND: Blood transfusions have the potential to improve graft survival, induce sensitization, and transmit infections. Current clinical practice is to minimize transfusions in renal transplantation candidates, but it is unclear if the evidence continues to support pre-transplant transfusion avoidance. Changes in the Medicare prospective payment system may increase transfusion rates. Thus there is a need to re-evaluate the literature to improve the management options for renal transplant candidates.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta-analysis

OBJECTIVES: There remains controversy regarding the efficacy of thiopurine analogs (azathioprine (AZA) and 6-mercaptopurine (6-MP)), methotrexate (MTX), and cyclosporine for the treatment of inflammatory bowel disease (IBD). We performed an updated systematic review of the literature to clarify the efficacy of immunosuppressive therapy at inducing remission and preventing relapse in ulcerative colitis (UC) and Crohn's disease (CD).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

The effect of treatment on radiological progression in rheumatoid arthritis: a systematic review of randomized placebo-controlled trials

This review assessed the effectiveness of drug treatments in preventing bone erosion (determined from X-rays) in rheumatoid arthritis. The authors concluded that cyclosporine, infliximab, sulphasalazine, leflunomide, methotrexate, parenteral gold, corticosteroids, auranofin and IL-1-RA are more effective than placebo. This conclusion appears reliable. Conclusions about relative effectiveness of different drugs were derived from indirect comparisons and may not be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Etanercept and efalizumab for the treatment of psoriasis: a systematic review

Psoriasis is a common inflammatory skin disease, with estimates of its world prevalence ranging from 0.5 to 4.6% and UK prevalence estimated at around 1.5%. Psoriasis generally occurs in adults, with males and females being equally commonly affected by the condition. Ethnic variations have been identified and Caucasians are more likely to suffer from the disease. Psoriasis is a chronic disorder that can be physically and emotionally debilitating and which can require life-long treatment. Plaque psoriasis, characterised by clearly demarcated, red, scaling plaques, is the most common form of psoriasis, occurring in more than 80% of cases. In the UK, both etanercept (Enbrel®) and efalizumab (Raptiva®) have recently been licensed for the treatment of adults with moderate to severe plaque psoriasis who have failed to respond to, or who have a contraindication to, or are intolerant to other systemic therapies including ciclosporin, methotrexate or photochemotherapy (PUVA). Both etanercept and efalizumab are new biological agents, which target pathologic T cell activity. Other therapies available for the treatment of moderate to severe psoriasis include phototherapy and systemic agents such as ciclosporin, methotrexate and retinoids, all of which have limitations on their use due to serious long-term adverse effects.

NIHR Health Technology Assessment programme: Executive Summaries - NIHR Evaluation, Trials and Studies Coordinating Centre (UK).

Version: 2006

Chronic kidney disease after hematopoietic cell transplantation: a systematic review

This review concluded that chronic kidney disease after haematopoietic stem cell transplantation was likely to be common and affect a significant proportion of patients who survived beyond 100 days post transplantation, but further confirmation was required. The authors' conclusions appeared cautious, but the review findings may not be reliable considering the numerous limitations in the review methods and study data.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Treatments for chronic palmoplantar pustulosis (a skin disease where repeated crops of painful yellow pus spots form on the palms and soles)

Chronic palmoplantar pustulosis is a skin disease where repeated crops of painful yellow pus spots form on the palms and soles, often over many years. Many different treatments have been used including topical creams and ointments, drugs by mouth and ultraviolet radiation. The review of trials found that several treatments improve the symptoms of chronic palmoplantar pustulosis, although no treatment was shown to suppress the condition completely. Oral retinoid therapy (acitretin) appears to be helpful at relieving symptoms, particularly if combined with PUVA. Ciclosporin and tetracycline antibiotics can also provide some relief. Topical treatments were generally less helpful. As yet there is no ideal treatment for chronic palmoplantar pustulosis, though oral retinoids, particularly when combined with psoralens and ultraviolet radiation (PUVA), may help

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

The clinical effectiveness and cost-effectiveness of treatments for children with idiopathic steroid-resistant nephrotic syndrome: a systematic review

Nephrotic syndrome is a collection of signs and symptoms, including protein in the urine, low blood protein levels, high cholesterol levels and swelling. First line treatment is with oral corticosteroids, but some children do not respond to this treatment. The optimal treatment of steroid-resistant nephrotic syndrome (SRNS) is uncertain.

NIHR Health Technology Assessment programme: Executive Summaries - NIHR Evaluation, Trials and Studies Coordinating Centre (UK).

Version: 2007

Systemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review

The authors concluded that based on the evidence, infliximab and adalimumab were the most effective immunosuppressive agents for hidradenitis suppurativa. Due to the limited synthesis and evidence presented in the review, the authors' conclusions are unlikely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Systematic Reviews in PubMed

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