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Injection: Prevents tuberculosis (TB). This medicine is a vaccine, and is also called BCG vaccine.

Intradermal route: Bacillus Calmette-Guérin (BCG) vaccine is given by injection to help prevent tuberculosis (TB).

Intravesical route: Bacillus Calmette-Guérin (BCG) is used as a solution that is run through a tube (instilled through a catheter) into the bladder to treat bladder cancer.

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Results: 1 to 20 of 30

Intravesical therapy with Bacillus Calmette-Guerin following transurethral resection in patients with superficial bladder cancer: a meta-analysis of randomized controlled trials

Bibliographic details: Li J, Chen GJ.  Intravesical therapy with Bacillus Calmette-Guerin following transurethral resection in patients with superficial bladder cancer: a meta-analysis of randomized controlled trials. Chinese Journal of Cancer Biotherapy 2011; 18(1): 70-74

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Protective effect of bacillus Calmette Guerin (BCG) vaccine in the prevention of leprosy: a meta-analysis

BACKGROUND: Although the role of bacillus Calmette Guerin (BCG) vaccine in the prevention of leprosy was hypothesized as early as 1939, its level of protective effect remained controversial.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Intravesical Bacillus Calmette-Guerin versus mitomycin C for superficial bladder cancer: a formal meta-analysis of comparative studies on recurrence and toxicity

PURPOSE: We compare the therapeutic efficacy and toxicity of intravesical bacillus Calmette-Guerin (BCG) with mitomycin C on recurrence of stages Ta and T1 bladder carcinoma.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus Bacillus Calmette-Guerin for non-muscle-invasive bladder cancer

This individual patient data meta-analysis concluded that maintenance BCG was superior to mitomycin C in reducing recurrence of bladder cancer. Overall, the results appear reliable although they were based on studies with differing patient characteristics, treatment regimens and follow-up schedules.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Can intravesical bacillus Calmette-Guerin reduce recurrence in patients with superficial bladder cancer: a meta-analysis of randomized trials

The authors concluded that adjuvant intravesical bacillus Calmette-Guerin in a maintenance regimen is effective in the prophylaxis of tumour recurrence in patients with superficial bladder cancer, especially papillary tumours. This conclusion should be viewed with some degree of caution as differences between the studies were not accounted for in the stratified analyses.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

The influence of intravesical therapy on progression of superficial transitional cell carcinoma of the bladder: a metaanalytic comparison of chemotherapy versus bacilli Calmette-Guerin immunotherapy

OBJECTIVE: Currently, the true impact of intravesical chemotherapy or immunotherapy (bacilli Calmette-Guerin [BCG]) on the rate of progression of superficial transitional cell carcinoma of the bladder to muscle invasive disease is unclear. A metaanalysis was performed to statistically compare the efficacy of these treatments in preventing tumor progression in this disease setting.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

Bacille Calmette-Guerin vaccine-related disease in HIV-infected children: a systematic review

This review found that data on the risk of bacillus Calmette-Guerin vaccination in HIV-infected infants were limited. Despite of the lack of reporting of the review process, possible publication and language bias and poor quality studies, the authors' conclusion reflects the data presented.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guerin vaccination against tuberculosis

BACKGROUND: Recent evidence suggests that the duration of protection by bacillus Calmette-Guérin (BCG) may exceed previous estimates with potential implications for estimating clinical and cost-efficacy.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Safety of Vaccines Used for Routine Immunization in the United States

To conduct a systematic review of the literature on the safety of vaccines recommended for routine immunization of children, adolescents, and adults in the United States as of 2011.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: July 2014
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Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies

BACKGROUND: Results have been conflicting as to whether Bacillus Calmette-Guérin (BCG) vaccine, a non-specific stimulator of the immune function, protects, predisposes or is unrelated to the development of childhood asthma. In this systematic review and meta-analysis, we qualitatively and quantitatively appraised the epidemiological evidence.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Is childhood vaccination associated with asthma: a meta-analysis of observational studies

BACKGROUND: The possible link between immunization and atopic diseases has been under intense debate in the last decade.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

The role of BCG in prevention of leprosy: a meta-analysis

The present meta-analysis investigates the role of BCG-a widely used yet controversial vaccine-in the prevention of leprosy. The electronic databases Medline, Embase, the Cochrane Library, and LILACS were searched to identify studies assessing the protective effect of BCG against leprosy. We included seven experimental studies and 19 observational studies. The experimental studies demonstrated an overall protective effect of 26% (95% CI 14-37%). At 61% (95% CI 51-70%), the observational studies overestimated the protective effect. The age at vaccination did not predict the protective effect of BCG. An additional dose of BCG was more protective in the prevention of leprosy compared with a single dose. An additional dose of BCG may be warranted for contacts of leprosy patients in areas where leprosy continues to be a public-health problem.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Interferon- release assays for the diagnosis of latent mycobacterium tuberculosis infection: a systematic review and meta-analysis

We conducted a systematic review and meta-analysis to compare the accuracy of the QuantiFERON-TB® Gold In-Tube (QFT-G-IT) and the T-SPOT®.TB assays with the tuberculin skin test (TST) for the diagnosis of latent Mycobacterium tuberculosis infection (LTBI). The Medline, Embase and Cochrane databases were explored for relevant articles in November 2009. Specificities, and negative (NPV) and positive (PPV) predictive values of interferon-γ release assays (IGRAs) and the TST, and the exposure gradient influences on test results among bacille Calmette-Guérin (BCG) vaccinees were evaluated. Specificity of IGRAs varied 98-100%. In immunocompetent adults, NPV for progression to tuberculosis within 2 yrs were 97.8% for T-SPOT®.TB and 99.8% for QFT-G-IT. When test performance of an immunodiagnostic test was not restricted to prior positivity of another test, progression rates to tuberculosis among IGRA-positive individuals followed for 19-24 months varied 8-15%, exceeding those reported for the TST (2-3%). In multivariate analyses, the odd ratios for TST positivity following BCG vaccination varied 3-25, whereas IGRA results remained uninfluenced and IGRA positivity was clearly associated with exposure to contagious tuberculosis cases. IGRAs may have a relative advantage over the TST in detecting LTBI and allow the exclusion of M. tuberculosis infection with higher reliability.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Intravesical bacille Calmette-Guerin versus mitomycin C in superficial bladder cancer: formal meta-analysis of comparative studies on tumor progression

OBJECTIVES: To compare the therapeutic efficacy of intravesical bacille Calmette-Guérin (BCG) with mitomycin C (MMC) on progression of Stage Ta and T1 bladder carcinoma.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection. An update

This review reported that IGRAs, particularly QuantiFERON-TB Gold and Gold In-Tube, had excellent specificity, as did the tuberculin skin test in non-BCG-vaccinated people. Sensitivity was not consistent across tests, but T-SPOT.TB seemed to be more sensitive. The limitations of both the included studies and the review mean that the results should be treated with some caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control

The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of published data including recently published studies (up to June 2009) to determine the efficacy of BCG protection on leprosy and to investigate whether age at vaccination, clinical form, number of doses, type of study, the latitude of study area and year of publication influence the degree of efficacy and explain the variation. In the light of the results, we argue for more emphasis on the role of BCG vaccination in leprosy control and research.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Preventive effects of Mycobacterium vaccae on HIV-associated tuberculosis: a systematic review

OBJECTIVE: To evaluate the effectiveness and safety of Mycobacterium vaccae (M.vaccae, MV) for prevention of HIV-associated tuberculosis (TB).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

BCG vaccination and allergy: a systematic review and meta-analysis

The review found that pre-school BCG vaccination was unlikely to protect against allergic sensitisation, atopic eczema and allergic rhinoconjunctivitis. A possible benefit in relation to asthma was unlikely to be due to allergic sensitisation. In view of the reported poor quality of the included studies and heterogeneity between them, these conclusions should be interpreted with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Tuberculosis: Clinical Diagnosis and Management of Tuberculosis, and Measures for Its Prevention and Control

This is the full version of NICE clinical guideline 117. It contains details of the methods and evidence used to develop the guideline. It updates and replaces the full version of ‘Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control’ that was developed by the National Collaborating Centre for Chronic Conditions and published by the Royal College of Physicians in March 2006. The updated recommendations have been developed by the Centre for Clinical Practice at NICE following the NICE short clinical guideline process. New recommendations on the use of interferon-gamma tests for the diagnosis of latent tuberculosis have been added.

NICE Clinical Guidelines - National Institute for Health and Clinical Excellence (UK).

Version: March 2011
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Contact Investigations following Patient and Staff Exposure to Active Tuberculosis Infections: A Review of the Clinical Evidence and Guidelines [Internet]

The nosocomial transmission of tuberculosis (TB) in healthcare facilities is a major public health concern. Studies showed that latent TB infection (LTBI) rate among healthcare workers is higher than among general population, and the incidence is higher in healthcare workers who work in high-risk areas. This Rapid Response report aims to review the clinical evidence regarding factors that trigger the need for a contact investigation following patient and staff exposure to a patient with TB in a hospital setting. Evidence-based guidelines associated with best practice for contact investigation will also be examined.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: April 30, 2014
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