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Comparing Drugs for Overactive Bladder Syndrome

How do anticholinergics compare in treating overactive bladder syndrome?

PubMed Clinical Q&A [Internet] - National Center for Biotechnology Information (US).

Version: October 1, 2010

Non-surgical Treatments for Urinary Incontinence: A Review of the Research for Women

The information in this summary is from a report that reviewed 905 studies between January 1990 and December 2011 on treatments without surgery for urinary incontinence. You can use the information from research to understand what is known about the possible benefits and side effects of each treatment option. This information will help you talk with your doctor about what option may be best for you.

Comparative Effectiveness Review Summary Guides for Consumers [Internet] - Agency for Healthcare Research and Quality (US).

Version: April 9, 2012

Non‐invasive electrical stimulation for overactive bladder in adults

People with overactive bladder (OAB) have a frequent and compelling desire to urinate, which has a significant impact on quality of life. Many people with OAB also have urinary incontinence. OAB affects around 17% of the world's population and is particularly common in elderly people. Treatment for OAB includes pelvic floor muscle training, drug therapy and electrical stimulation.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2016

Which anticholinergic drug for overactive bladder symptoms in adults

Many adults have symptoms of overactive bladder. A person with overactive bladder syndrome feels a very strong urge to pass urine and they may not make it to the toilet before they leak urine. Other common problems are a feeling of needing to urinate often during the day or night, or both. This problem seems to be caused by an overactive bladder muscle, and it becomes more common with ageing. Treatments are conservative measures, such as bladder training or drugs. Anticholinergic drugs can reduce the overactivity of the bladder muscle and the feeling of urgency. The review found that there are several anticholinergic drugs prescribed for adults with overactive bladder symptoms. The two most studied drugs are oxybutynin and tolterodine. These two drugs have similar effects but, on average, those taking oxybutynin were more likely to withdraw from the studies because of adverse effects, mainly dry mouth. However, both drugs can give dry mouth and this problem is less likely if an extended release formulation of either drug is used. Two newer drugs are solifenacin and fesoterodine. Solifenacin has a better effect and less risk of dry mouth compared to tolterodine. Fesoterodine has a better effect than extended release tolterodine but withdrawal from studies due to adverse effects and dry mouth was more likely.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Mirabegron (Betmiga) for overactive bladder: Overview

Mirabegron (trade name: Betmiga) has been approved in Germany since December 2012 for the treatment of overactive bladder in adults.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: September 1, 2014

Anticholinergic drugs in patients with overactive bladder syndrome.

An overactive bladder is a condition in which bladder contracts suddenly without any control, resulting in feeling to urinate and or leakage of urine. This is a common condition in adults and is also called as 'irritable' bladder or detrusor instability, urge or urgency‐frequency syndrome. Overactive bladder becomes more common with advancing age. Anticholinergic drugs mainly by their muscle relaxant action can help adults with symptoms of urinary frequency, urgency and urge incontinence.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Pelvic floor muscle training added to another active treatment versus the same active treatment alone for urinary incontinence in women

Involuntary leakage of urine (urinary incontinence) affects women of all ages, particularly older women who live in residential care, such as nursing homes. Some women leak urine during exercise or when they cough or sneeze (stress urinary incontinence). This may occur as a result of weakness of the pelvic floor muscles, which may be a result of factors such as damage during childbirth. Other women leak urine before going to the toilet when there is a sudden and compelling need to pass urine (urgency urinary incontinence). This may be caused by involuntary contraction of the bladder muscle. Mixed urinary incontinence is the combination of both stress and urgency urinary incontinence. Pelvic floor muscle training is a supervised treatment that involves muscle‐clenching exercises to strengthen the pelvic floor muscles. It is a common treatment used by women to stop urine leakage. Other treatments are also available, which can be used either alone, or in combination with pelvic floor muscle training.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Systematic Reviews in PubMed

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