Home > Search Results

Fusidic acid is a substance that is used to treat bacterial infections.

UsesSide effectsLatest evidence reviewsResearch summaries for consumersBrand names

Results: 13

Interventions for the prevention of mastitis following childbirth

Healthcare authorities and the World Health Organization recommend that newborn infants should exclusively be given breast milk until they are six months of age. Breastfeeding provides health benefits for the infant, including improved nutrition and protection against illnesses such as gastroenteritis, respiratory and ear infections, urinary tract infections, allergies and diabetes mellitus. Breastfeeding also saves on costs and has benefits for the mother. Mastitis is a significant complication of lactation and may stop some mothers from breastfeeding. The nipple becomes sore and the breast tender and swollen. If the nipple cracks, the breast can become infected and the mother may experience flu‐like symptoms. Poor breast attachment and inadequate emptying of milk from the breast when feeding may contribute to developing mastitis. It is important to investigate preventive measures in order to maintain and increase breastfeeding exclusivity and duration.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Interventions for the skin infection impetigo

Impetigo causes blister‐like sores. The sores can fill with pus and form scabs, and scratching can spread the infection. Impetigo is caused by bacteria. It is contagious and usually occurs in children. It is the most common bacterial skin infection presented by children to primary care physicians. Treatment options include topical antibiotics (antibiotic creams), oral antibiotics (antibiotics taken by mouth), and disinfectant solutions. There is no generally agreed standard treatment, and the evidence on what intervention works best is not clear.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

A systematic review and meta-analysis of treatments for impetigo

BACKGROUND: Impetigo is a common clinical problem seen in general practice. Uncertainty exists as to the most effective treatment, or indeed if treatment is necessary.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Antibiotic therapy for Clostridium difficile‐associated diarrhea in adults

Diarrhea may be a side effect of many commonly used antibiotics, and in some cases may be due to overgrowth of a bacterium called Clostridium difficile (C. difficile) in the colon after other bacteria have been killed. The seriousness of C. difficile‐associated diarrhea (CDAD) can range from being a nuisance, to a life threatening or even fatal disease. The treatment of CDAD is usually cessation of the initiating antibiotic and immediate administration of a different antibiotic. However each of these steps, cessation of the original antibiotic, immediate retreatment, and the choice of a new antibiotic are poorly supported by currently available evidence. Fifteen studies (total 1152 participants) of antibiotic treatment of CDAD were included in this review. Nine different antibiotics were investigated: vancomycin, metronidazole, fusidic acid, nitazoxanide, teicoplanin, rifampin, rifaximin, bacitracin and fidaxomicin (OPT‐80). Most of the studies were compared vancomycin with other antibiotics. Vancomycin was found to be superior to placebo (fake medicine) for improvement of the symptoms of CDAD including resolution of diarrhea. Most of the studies found no statistically significant difference in effectiveness between vancomycin and other antibiotics including metronidazole, fusidic acid, nitazoxanide or rifaximin. Teicoplanin was found to be superior to vancomycin for curing the C. difficile infection. Teicoplanin may be an attractive choice for the treatment of CDAD. However, it is expensive compared to the other antibiotics and is of limited availability. Side effects including surgery and death occurred infrequently in the included studies. There was a total of 18 deaths among 1152 patients in this systematic review. These deaths were attributed to underlying disease rather than CDAD or antibiotic treatment. One study reported a partial colectomy (removal of the diseased part of the colon) after failed CDAD treatment. It is questionable whether mild CDAD needs to be treated. The included studies provide little evidence for antibiotic treatment of severe CDAD as many studies attempted to exclude these patients. Considering the goals of CDAD therapy: improvement of the patient's clinical condition and prevention of spread of C. difficile infection to other patients, one should choose the antibiotic that brings both symptomatic cure and bacteriologic cure. A recommendation to achieve these goals cannot be made because of the small numbers of patients in the included studies and the poor methodological quality of these studies. Over time there have been emerging therapies for the treatment of clostridium difficile such as resins, new biological compounds and probiotics as alternatives to antibiotics. These interventions along with antibiotic therapy for Clostridium difficile‐associated diarrhea need further investigation. 

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Impetigo: What can make it go away faster?

Research shows that smaller impetigo infections go away faster when they are treated with particular antibiotic ointments. It is not clear whether disinfectant ointments can help.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: March 12, 2014

Antimicrobial drugs for treating methicillin‐resistant Staphylococcus aureus colonization

Staphylococcus aureus is a bacterium that can cause serious infections. Methicillin‐resistant S. aureus (MRSA) refers to strains of S. aureus that are resistant to many antibiotics including the penicillins. Hospital infection control staff want to limit the spread of MRSA for several reasons and one of the ways of doing this is to use either topical or oral antimicrobial drugs in an attempt to eradicate MRSA from individuals who are colonized. However there is insufficient evidence to support the use of topical or oral antimicrobial therapy for eradicating nasal or extra‐nasal MRSA. No one type of treatment either topical or oral or a combinations of both showed a superior effect. Potentially serious adverse events and development of antimicrobial resistance can result from therapy.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2008

Drug Class Review: Topical Calcineurin Inhibitors: Final Report [Internet]

Since December 2000, two topical calcineurin inhibitors have been approved for use in patients with atopic dermatitis in the United States and Canada. Since the approval of these agents, several case reports of malignancies (skin and lymphoma) have been reported to the United States Food and Drug Administration, causing a black box warning to be placed in each product's labeling. Several pharmacokinetic analyses, commentaries, and editorials have been published refuting the addition of the black box warning. In light of these findings, this comparative effectiveness review of 2 topical calcineurin inhibitors was commissioned to identify whether additional good-quality studies on safety have been published and to determine whether differences in efficacy and effectiveness exist between the 2 topical agents. The purpose of this review is to compare the effectiveness and harms of topical calcineurin inhibitors in persons with atopic dermatitis or eczema.

Drug Class Reviews - Oregon Health & Science University.

Version: October 2008
Show search results within this document

Atopic Eczema in Children: Management of Atopic Eczema in Children from Birth up to the Age of 12 Years

Atopic eczema (atopic dermatitis) is a chronic inflammatory itchy skin condition that develops in early childhood in the majority of cases. It is typically an episodic disease of exacerbation (flares, which may occur as frequently as two or three per month) and remissions, except for severe cases where it may be continuous. Certain patterns of atopic eczema are recognised. In infants, atopic eczema usually involves the face and extensor surfaces of the limbs and, while it may involve the trunk, the napkin area is usually spared. A few infants may exhibit a discoid pattern (circular patches). In older children flexural involvement predominates, as in adults. Diagnostic criteria are discussed in Chapter 3. As with other atopic conditions, such as asthma and allergic rhinitis (hay fever), atopic eczema often has a genetic component. In atopic eczema, inherited factors affect the development of the skin barrier, which can lead to exacerbation of the disease by a large number of trigger factors, including irritants and allergens. Many cases of atopic eczema clear or improve during childhood while others persist into adulthood, and some children who have atopic eczema `will go on to develop asthma and/or allergic rhinitis; this sequence of events is sometimes referred to as the ‘atopic march’. The epidemiology of atopic eczema is considered in Chapter 5, and the impact of the condition on children and their families/caregivers is considered in Sections 4.2 and 4.3.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: December 2007
Show search results within this document

Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection [Internet]

To conduct a systematic review and synthesize evidence for differences in the accuracy of diagnostic tests, and the effects of interventions to prevent and treat Clostridium difficile infection (CDI) in adult patients.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: December 2011
Show search results within this document

Vancomycin or Metronidazole for Treatment of Clostridium difficile Infection: Clinical and Economic Analyses [Internet]

Clostridium difficile (C. difficile) infection is the most common cause of nosocomial infectious diarrhea in adults. The spread of a hypervirulent strain of C. difficile has caused recent outbreaks of C. difficile infection. Metronidazole and vancomycin are the antibiotics of choice to treat C. difficile infection. An assessment was prepared to help guide the choice of therapy for C. difficile infection and to inform reimbursement policies in the Canadian publicly funded health care system.

CADTH Technology Report - Canadian Agency for Drugs and Technologies in Health.

Version: January 2011
Show search results within this document

Fecal Microbiota Transplantation for Clostridium Difficile Infection: A Systematic Review of the Evidence [Internet]

The Minneapolis VA Evidence-based Synthesis Program was asked to conduct a systematic evidence review regarding the effectiveness of fecal microbiota transplantation (FMT) for treatment of C. difficile infection (CDI), in part to help guide policy makers within the Veterans Health Administration determine if the evidence supporting MT was sufficient to implement FMT programs in their facilities. The topic was nominated by Jason Dominitz, MD, MHS on behalf of the VA Gastroenterology Field Advisory Committee.

Evidence-based Synthesis Program - Department of Veterans Affairs (US).

Version: July 2014
Show search results within this document

Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence

This review assessed the effectiveness of linezolid for the treatment of patients with infective endocarditis. The authors concluded that limited data suggest that linezolid should be considered in patients with infective endocarditis with limited treatment options but randomised controlled trials are required. These conclusions reflect the evidence presented, but their reliability is limited by methodological weaknesses of the review.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Eradication of methicillin-resistant Staphylococcus aureus carriage: a systematic review

This review found short-term nasal application of mupirocin was the most effective treatment for the eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage. While the authors' conclusion reflected the evidence presented, the results should be treated with some degree of caution given a number of shortcomings, unexplained heterogeneity in the oral antibiotics trials, and the limited evidence directly comparing different treatments.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Systematic Reviews in PubMed

See all (24)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...