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By mouth: Treats infections. This medicine is a macrolide antibiotic.

Injection: This medicine is a macrolide antibiotic used to treat bacterial infections. Also used to prevent heart infection and rheumatic fever in patients who have had an allergic reaction to penicillin or sulfa drugs.

Into the eye: Treats eye infections. Belongs to a class of drugs called antibiotics.

On the skin: Used on the skin to treat acne. Belongs to a class of drugs called antibiotics.

UsesSide effectsLatest evidence reviewsResearch summaries for consumersBrand names

Results: 1 to 20 of 107

Erythromycin for preventing and treating preterm infants with feeding difficulties

There is not enough evidence to show any benefit from erythromycin used in large or small doses for the prevention or treatment of feeding problems in premature infants. Premature infants who need intensive care often have feeding problems. Frequently, some food stays in the stomach without being digested. Earlier feeding can facilitate normal development of the gastrointestinal tract and can avoid health problems related to feeding by intravenous lines. Erythromycin is an antibiotic that has an effect on the gastrointestinal tract and may help infants with feeding problems. However, this review found that there is not enough evidence to recommend the use of erythromycin in small or large doses to prevent or treat premature infants with feeding problems.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2008

Erythromycin for the prevention of chronic lung disease in intubated preterm infants at risk for, or colonized or infected with Ureaplasma urealyticum

More evidence needed on using antibiotics to try and prevent chronic lung disease in preterm babies testing positive for U urealyticum. Chronic lung disease (CLD) is a major health risk often faced by preterm babies on ventilation (machine‐assisted breathing). Ureaplasma urealyticum is a common type of infection that may be one of the causes of CLD, although this has not been proven. Erythromycin is an antibiotic used for other infections caused by U urealyticum. When a baby tests positive for U urealyticum, erythromycin has been tried as a preventive measure. The review found that there is not enough evidence from trials to show whether or not testing preterm babies for U urealyticum and using erythromycin can prevent CLD or mortality.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Erythromycin infusion prior to emergency endoscopy for acute upper gastrointestinal bleeding: a systematic review

Bibliographic details: Zhou J, He JD, Ouyang XB, Wang YP.  Erythromycin infusion prior to emergency endoscopy for acute upper gastrointestinal bleeding: a systematic review. World Chinese Journal of Digestology 2009; 17(31): 3273-3277

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Effects of low-dose erythromycin on patients with stable COPD: a meta-analysis

Bibliographic details: Feng J, Tang XJ, Chen YF, Liang YS, Yuan L, Luo FM.  Effects of low-dose erythromycin on patients with stable COPD: a meta-analysis. Chinese Journal of Evidence-Based Medicine 2014; 14(2): 191-196 Available from: http://www.cjebm.org.cn/en/oa/DArticle.aspx?type=view&id=20140202

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Macrolides for diffuse panbronchiolitis

To summarise the evidence about the effect and safety of macrolide antibiotics for diffuse panbronchiolitis (DPB).

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Interventions for the skin infection impetigo

Impetigo causes blister‐like sores. The sores can fill with pus and form scabs, and scratching can spread the infection. Impetigo is caused by bacteria. It is contagious and usually occurs in children. It is the most common bacterial skin infection presented by children to primary care physicians. Treatment options include topical antibiotics (antibiotic creams), oral antibiotics (antibiotics taken by mouth), and disinfectant solutions. There is no generally agreed standard treatment, and the evidence on what intervention works best is not clear.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Antibiotics to treat adults with acute laryngitis

Cochrane authors reviewed the available evidence from randomised controlled trials on the use of antibiotics for adults with acute laryngitis.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Interventions for pityriasis rosea, skin rash of unknown cause

Pityriasis rosea is a scaly rash that mostly affects young adults. It is relatively common and affects about 170 out of every 100,000 people in the community each year. The first sign is a patch of scales, usually on the trunk. A generalised eruption then follows and all lesions disappear within 2 to 12 weeks. This review is important because about 50% of people with pityriasis rosea experience moderate to severe itch. It is not known whether the current treatments, which include tablets, creams, and ultra‐violet radiation, are useful and whether the benefits outweigh the risk of adverse effects.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Antibiotics for whooping cough (pertussis)

Whooping cough is a highly contagious disease caused by pertussis bacteria and may lead to death, particularly in infants less than 12 months of age. Although it can be prevented by routine vaccination, it still affects many people. Thirteen trials involving 2197 participants were included in this review. We found that several antibiotic treatments were equally effective in eliminating the bacteria infecting patients, but they did not alter the clinical outcome. There was insufficient evidence to decide whether there is benefit for treating healthy contacts. Side effects were reported with antibiotics and they varied from one antibiotic to another. The result of the review should be interpreted with caution since this review is based on a limited number of trials and some of these trials involved small numbers of participants.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Antibiotics for ureaplasma in the vagina in pregnancy

Ureaplasmas are normal flora in the vagina of many women. In some women high levels of ureaplasma in the vagina, which probably reflect the presence of infection in the uterus, may have a role in pregnancy complications, or may contribute to babies being born before full term (preterm birth), or both. These babies can have serious health problems. Some antibiotics can be safely used during pregnancy and are also active against ureaplasma. The authors identified only one trial (involving 1071 women) that was eligible for inclusion in this review. Therefore, there is insufficient data to assess whether giving antibiotics to women with ureaplasma in the vagina reduces the risk of preterm birth.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Therapies for BCG induced disease in children

Bacillus Calmette‐Guérin (BCG) is a widely used tuberculosis vaccine derived from a non‐infectious strain of the bovine tuberculosis bacillus (Mycobacterium bovis) and mainly given to young children. Usually, the only adverse reaction to the vaccine is an ulcer at the site of injection, which may leave a small scar.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Meta-analysis: erythromycin before endoscopy for acute upper gastrointestinal bleeding

BACKGROUND: Studies evaluating the effect of erythromycin on patients with acute upper gastrointestinal bleeding (UGIB) had been reported, but the results were inconclusive.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Antibiotics to treat respiratory infections caused by the bacteria Mycoplasma pneumoniae in children

This review sought to answer the question of whether antibiotics are effective in the treatment of LRTIs caused by the bacteria Mycoplasma pneumoniae (M. pneumoniae) in children.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Antibiotics for bronchiolitis in children under two years of age

We reviewed the evidence on the effect of antibiotics on clinical outcomes in children with bronchiolitis.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Erythromycin prior to endoscopy in acute upper gastrointestinal bleeding: a meta-analysis

OBJECTIVE: Upper gastrointestinal bleeding (UGIB) is a medical emergency requiring urgent endoscopy and diagnosis. However, adequate visualization is a necessity. Studies have been performed evaluating the efficacy of erythromycin infusion prior to endoscopy to improve visibility and therapeutic potential of esophagogastroduodenoscopy (EGD) with varied results. Therefore, a meta-analysis was performed comparing the efficacy of erythromycin infusion prior to endoscopy in acute UGIB.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Administration of erythromycin before endoscopy in upper gastrointestinal bleeding: a meta-analysis of randomized controlled trials

BACKGROUND/AIM: Erythromycin infusion before endoscopy in upper gastrointestinal bleeding (UGIB) has been hypothesized to aid in visualization and reduce the need for second-look endoscopy; however, the results have been controversial. To evaluate further, we performed a meta-analysis comparing the efficacy of erythromycin infusion before endoscopy in acute UGIB.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Erythromycin for improving enteral nutrition tolerance in adult critical patients: a systematic review and meta-analysis

OBJECTIVE: To systematically review the efficacy and safety of erythromycin on enteral nutrition (EN) tolerance in adult critical care patients.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Erythromycin for improving enteral nutrition tolerance in adult critical patients: a systematic review and Meta-analysis

OBJECTIVE: To systematically review the efficacy and safety of erythromycin on enteral nutrition (EN) tolerance in adult critical care patients.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Oral erythromycin and symptomatic relief of gastroparesis: a systematic review

This review concluded that there is insufficient data from clinical trials to assess the efficacy of erythromycin for symptom relief in gastroparesis. The conclusions follow from the evidence presented but should be treated with caution because the search was limited and the number of studies and patients involved was small.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Erythromycin as a prokinetic agent in preterm neonates: a systematic review

This review assessed the efficacy and safety of erythromycin as a prokinetic agent in pre-term neonates. The authors concluded that differences between the studies made it difficult to draw any clear conclusions. The authors' conclusions correctly reflect the many well-described differences between the studies and are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Systematic Reviews in PubMed

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