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Treats infections caused by certain types of bacteria. This medicine is a cephalosporin antibiotic.

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Results: 1 to 20 of 40

Ertapenem versus ceftriaxone for the treatment of complicated infections: a meta-analysis of randomized controlled trials

BACKGROUND: Ertapenem has been demonstrated to be highly effective for the treatment of complicated infections. The aim of this study was to compare the efficacy and safety of ertapenem with ceftriaxone.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Efficacy and safety of ceftriaxone for uncomplicated gonorrhoea: a meta-analysis of randomized controlled trials

The authors concluded that better efficacy, for uncomplicated gonorrhoea, was found for ceftriaxone 250mg versus cefixime 400mg, and for ceftriaxone 125mg versus spectinomycin 2g. Unexplained statistical variation, potential reporting bias, and a high risk that bias could have affected the pooled results, mean that the authors' conclusions may not be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

A meta-analysis of randomized, controlled trials assessing the prophylactic use of ceftriaxone: a study of wound, chest, and urinary infections

This review concluded that prophylactic ceftriaxone was more effective than most other prophylactic antibiotics and reduced incisional surgical site infection, urinary tract infection and pneumonia in surgery procedures that had an increased risk of infections. The conclusions should be interpreted cautiously given the limited quality of most of the included studies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Antibiotics for the treatment of dysentery in children

The authors concluded that there was strong evidence in favour of the continued use of the antibiotics ciprofloxacin, ceftriaxone and pivmecillinam (as recommended by the World Health Organization) to reduce morbidity and mortality in children with dysentery. The review had some methodological problems, but the authors' conclusions were based on the evidence and appear reasonable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Management of Acute Otitis Media: Update

Acute Otitis Media (AOM), a viral or bacterial infection of the ear, is the most common childhood infection for which antibiotics are prescribed in the United States. In 2001, the Southern California Evidence-based Practice Center conducted a systematic review of the evidence comparing treatments of AOM.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: November 2010
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Chronic Venous Ulcers: A Comparative Effectiveness Review of Treatment Modalities [Internet]

To systematically review whether the use of advanced wound dressings, systemic antibiotics, or venous surgery enhanced the healing of venous ulcers over the use of adequate venous compression.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: December 2013
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Urinary Tract Infection in Children: Diagnosis, Treatment and Long-term Management

In the past 30–50 years, the natural history of urinary tract infection (UTI) in children has changed as a result of the introduction of antibiotics and improvements in health care. This change has contributed to uncertainty about the most appropriate and effective way to diagnose and treat UTI in children and whether or not investigations and follow-up are justified.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: August 2007
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Antibiotics for gonorrhoea in pregnancy

Pregnant women with gonorrhoea who take penicillin, spectinomycin or ceftriaxone are much less likely to show signs of infection.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Efficacy of short course (<4 days) of antibiotics for treatment of acute otitis media in children: a systematic review of randomized controlled trials

This review found no evidence of increased risk of treatment failure with short-course (<4 days) compared with long-course (?4 days) antibiotics for acute otitis media in children. The authors' conclusions are likely to be reliable, but should be interpreted with some caution due to a lack of detail on searches, quality assessment and individual study features.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Antibiotics in severely malnourished children: systematic review of efficacy, safety and pharmacokinetics

OBJECTIVE: To systemically review the evidence in support of World Health Organization guidelines recommending broad-spectrum antibiotics for children with severe acute malnutrition (SAM).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Antibiotics for preventing meningococcal infections

Meningococcal disease is a contagious bacterial disease caused by the bacteria Neisseria meningitidis (N.meningitidis) with high fatality rates: up to 15% for infection of the central nervous system (meningitis) and up to 50% to 60% among patients with blood stream infection and shock; up to 15% of survivors are left with severe neurological deficits. People who have had close contact with someone who has a meningococcal infection and populations with known high carriage rates are offered antibiotics in order to eradicate the bacteria and thus prevent disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Newer, third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis

Acute bacterial meningitis is a life‐threatening illness. Currently the evidence suggests that old and new antibiotics offer the same level of treatment. Bacteria which cause meningitis are often thought to be resistant to conventional (older) antibiotics, and so doctors often prescribe newer antibiotics (called third generation cephalosporins). Commencing treatment early is vitally important and the choice of antibiotic is often made without any knowledge of possible drug resistance. This review examined 19 studies with 1496 participants to see whether there is a difference in effectiveness between conventional and newer antibiotics. This review found no differences. Adverse effects in both approaches were similar, except for diarrhoea, which was more common in the cephalosporin group. Only three studies dealt with adults; the remaining studies recruited participants aged 15 years and younger. Therefore, we believe that the results probably pertain more to children. Conventional and newer antibiotics seem reasonable options for initial, immediate treatment. The choice may depend on availability, affordability and local policies.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Pre‐admission antibiotics for suspected cases of meningococcal disease

Meningococcal disease is a contagious, bacterial disease caused by Neisseria meningitidis (N. meningitidis) that, if not treated early, can rapidly lead to death or disabling consequences such as visual, hearing and intellectual impairments.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Antimicrobial treatment options for neurosurgical ventricular shunt infections in children from 1993 to 2012: a systematic review

PURPOSE: The aim of this systematic review was to review studies that existed from 1993 to 2012 regarding antimicrobial treatment options of paediatric neurosurgical shunt.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Short course antibiotics for healthy children with uncomplicated acute otitis media

Acute otitis media (AOM), or middle ear infection, is a common childhood illness, with more than half of all children having at least one infection by the time they are seven. Although otitis media often resolves without treatment, it is frequently treated with antibiotics. The length of treatment varies widely. This review of 49 trials found that treating children with a short course (less than seven days) of antibiotics, compared to treatment with a long course (seven days or greater) of antibiotics, increases the likelihood of treatment failure in the short term. No differences are seen one month later. The amount of gastrointestinal adverse events decreased with a shorter course of antibiotics.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Oral antibiotic therapy for the treatment of infective endocarditis: a systematic review

BACKGROUND: The role of oral antibiotic therapy in treating infective endocarditis (IE) is not well established.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

A meta-analysis comparing the safety and efficacy of azithromycin over the alternate drugs used for treatment of uncomplicated enteric fever

BACKGROUND: Drug-resistant typhoid fever is a major clinical problem globally. Emergence of multidrug-resistant (MDR) S. Typhi has complicated therapy by limiting treatment options.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Bacterial Meningitis and Meningococcal Septicaemia: Management of Bacterial Meningitis and Meningococcal Septicaemia in Children and Young People Younger than 16 Years in Primary and Secondary Care

This guideline covers bacterial meningitis and meningococcal septicaemia, focusing on management of these conditions in children and young people aged younger than 16 years in primary and secondary care, and using evidence of direct relevance to these age groups where available.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: 2010
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Fluoroquinolones for treating enteric fever

Researchers in The Cochrane Collaboration conducted a review of the effect of fluoroquinolone antibiotics in people enteric fever. After searching for relevant studies, they identified 26 studies involving 3033 patients. Their findings are summarized below.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Increased clinical failures when treating acute otitis media with macrolides: a meta-analysis

The review found that paediatric patients with acute otitis media and treated with macrolide antibiotics compared to first-line antibiotics may be more likely to have clinical failures. The authors' conclusions reflect the evidence presented, but limitations in the quality of many of the included studies mean the conclusions should be considered tentative.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Systematic Reviews in PubMed

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