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Nausea

A feeling of sickness or discomfort in the stomach that may come with an urge to vomit.

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(Source: NIH - National Cancer Institute)

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Evidence reviews

Levomepromazine for the treatment of nausea and vomiting in people with advanced disease

Nausea and vomiting are common and very unpleasant symptoms that are often experienced by people receiving palliative care. There are several different drug therapies which are available to treat these symptoms. Levomepromazine was originally used to treat schizophrenia but is also used to control nausea and vomiting. It can be given orally or as an injection. We were unable to identify any randomised controlled trials to find out if levomepromazine is an effective treatment for nausea and vomiting in patients receiving palliative care. There is a need for randomised studies to find out which drugs are the most effective treatments for such symptoms in these patients.

Haloperidol for the treatment of nausea and vomiting in palliative care patients

We did not identify any randomised controlled trials (RCTs) to find out if haloperidol is a useful drug for the treatment of nausea or vomiting in palliative care patients. Nausea and vomiting are common problems for patients with serious life threatening illnesses and haloperidol is a drug which is sometimes prescribed to help treat these symptoms. This drug can be given orally or by injection. There has been some research looking at how this drug works in sickness caused by surgery and when trying to prevent sickness caused by anti‐cancer treatments. During a search of the international literature no studies looking at this treatment in seriously ill or terminally ill patients were found. There is not enough evidence to be able to recommend haloperidol for the treatment of nausea and vomiting in adult patients suffering from incurable progressive medical conditions.

Drugs for preventing nausea and vomiting after surgery

We found eight drugs that reliably prevented nausea or vomiting after surgery. The drugs prevented nausea or vomiting in three or four people out of every 10 who would have vomited or felt nauseated with a placebo. We did not find reliable evidence that one drug was better than another. A person's age or sex, the type of surgery, or the time the drug was given did not change the effect of a drug. When drugs were given together, their effects simply added. Side effects were mild and affected four out of 100 people for the two drugs most studied.

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Summaries for consumers

Levomepromazine for the treatment of nausea and vomiting in people with advanced disease

Nausea and vomiting are common and very unpleasant symptoms that are often experienced by people receiving palliative care. There are several different drug therapies which are available to treat these symptoms. Levomepromazine was originally used to treat schizophrenia but is also used to control nausea and vomiting. It can be given orally or as an injection. We were unable to identify any randomised controlled trials to find out if levomepromazine is an effective treatment for nausea and vomiting in patients receiving palliative care. There is a need for randomised studies to find out which drugs are the most effective treatments for such symptoms in these patients.

Haloperidol for the treatment of nausea and vomiting in palliative care patients

We did not identify any randomised controlled trials (RCTs) to find out if haloperidol is a useful drug for the treatment of nausea or vomiting in palliative care patients. Nausea and vomiting are common problems for patients with serious life threatening illnesses and haloperidol is a drug which is sometimes prescribed to help treat these symptoms. This drug can be given orally or by injection. There has been some research looking at how this drug works in sickness caused by surgery and when trying to prevent sickness caused by anti‐cancer treatments. During a search of the international literature no studies looking at this treatment in seriously ill or terminally ill patients were found. There is not enough evidence to be able to recommend haloperidol for the treatment of nausea and vomiting in adult patients suffering from incurable progressive medical conditions.

Drugs for preventing nausea and vomiting after surgery

We found eight drugs that reliably prevented nausea or vomiting after surgery. The drugs prevented nausea or vomiting in three or four people out of every 10 who would have vomited or felt nauseated with a placebo. We did not find reliable evidence that one drug was better than another. A person's age or sex, the type of surgery, or the time the drug was given did not change the effect of a drug. When drugs were given together, their effects simply added. Side effects were mild and affected four out of 100 people for the two drugs most studied.

See all (573)

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Other terms to know:
Stomach, Vomiting

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