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Dysphoria is a profound state of unease or dissatisfaction. Dysphoria may accompany depression, anxiety, or agitation. It can also mean someone that is not comfortable in their current body, particularly in cases of gender dysphoria.

PubMed Health Glossary
(Source: Wikipedia)

What works? Research summarized

Evidence reviews

[Treatment of premenstrual dysphoria with antidepressants: review of controlled clinical trials]

Bibliographic details: Cheniaux E.  [Treatment of premenstrual dysphoria with antidepressants: review of controlled clinical trials]. [Tratamento da disforia pre-menstrual com antidepressivos: revisao dos ensaios clinicos controlados .] Jornal Brasileiro de Psiquiatria 2006; 55(2): 142-147

Drug Class Review: Second-Generation Antidepressants: Final Update 5 Report [Internet]

We compared the effectiveness and harms of second-generation antidepressants in the treatment of major depressive disorder (MDD), dysthymia, subsyndromal depression, seasonal affective disorder, generalized anxiety disorder, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder.

Preventing Alzheimer's Disease and Cognitive Decline

To assess whether previous research on purported risk or protective factors for Alzheimer’s disease (AD) and cognitive decline is of sufficient strength to warrant specific recommendations for behavioral, lifestyle, or pharmaceutical interventions/modifications targeted to these endpoints.

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Summaries for consumers

Central action beta‐blockers versus placebo for neuroleptic‐induced acute akathisia

Akathisia is recognised as one of the most common and distressing of the early‐onset adverse effects of neuroleptic drugs. This movement disorder is characterised by a subjective report of inner restlessness, mental unease or dysphoria, which can be intense.

Antidepressants for people with both schizophrenia and depression

Depression is common in people with schizophrenia and is associated with substantial problems including an increased risk of suicide. Many clinicians use antidepressant drugs in addition to anti‐psychotics in order to treat depression. This review identified eleven randomised controlled trials that compared antidepressants with a placebo in people with schizophrenia who also had depression. There was some evidence that antidepressants did lead to an improvement in global outcome, but the small number of studies providing usable data and their poor quality, suggest that this evidence should be interpreted with caution. At present, there is no convincing evidence either to support or refute the use of antidepressants in treating depression in people with schizophrenia. Further well‐designed, conducted and reported research is needed in this area.

More about Dysphoria

Photo of an adult

Also called: Dysphoric

See Also: Euphoria, Premenstrual Dysphoric Disorder

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