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Hodgkin Lymphoma

A malignant disease characterized by enlargement of the lymph nodes, spleen, and general lymphoid tissue. NIH - National Library of Mediciine

About Hodgkin Lymphoma

Adult Hodgkin Lymphoma

Adult Hodgkin lymphoma is a type of cancer that develops in the lymph system, part of the body's immune system.

The lymph system is made up of the following:

Childhood Hodgkin Lymphoma

Childhood Hodgkin lymphoma is a type of cancer that develops in the lymph system, which is part of the body's immune system....Read more about Childhood Hodgkin Lymphoma

What works? Research summarized

Evidence reviews

Meta-analysis on the efficacy and safety of R-CHOP chemotherapy for the treatment of low and moderate malignant B cell non-Hodgkin lymphoma

Bibliographic details: Feng JJ, Yang LH, Chen JF, Ma YP, Ma LM, Lai XW.  Meta-analysis on the efficacy and safety of R-CHOP chemotherapy for the treatment of low and moderate malignant B cell non-Hodgkin lymphoma. Journal of Leukemia and Lymphoma 2009; 18(4): 216-219

F-18 FDG PET for evaluation of bone marrow involvement in non-hodgkin lymphoma: a meta-analysis

This review concluded that positron emission tomography (PET) or PET/computed tomography (CT) had high accuracy for evaluation of bone marrow involvement in non-Hodgkin aggressive lymphoma patients. The summary estimates did not support these conclusions, which combined with limitations in the analysis and potential for missing studies means that the authors' conclusions should be interpreted with caution.

CNOP (mitoxantrone) chemotherapy is inferior to CHOP (doxorubicin) in the treatment of patients with aggressive non-Hodgkin lymphoma (meta-analysis)

This review concluded that doxorubicin (CHOP) chemotherapy was more effective than mitoxantrone (CNOP) at equitoxic (myelosuppression) doses with regard to complete remission in patients with aggressive non-Hodgkin lymphoma. CHOP was associated with greater risk of adverse effects. Given several limitations, including the small number of included studies and the potential for reporting bias, the authors’ conclusions may not be reliable.

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Summaries for consumers

Adult Hodgkin Lymphoma Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of adult Hodgkin lymphoma.

Childhood Hodgkin Lymphoma Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of childhood Hodgkin lymphoma.

Treatment of early stage Hodgkin lymphoma

Hodgkin lymphoma is a malignancy of the lymphatic system, first described by Thomas Hodgkin. It can occur in children and adults, but it is more common in the third decade of life. It is one of the most curable forms of cancer. Clinically speaking, there are four stages of Hodgkin lymphoma. Generally, stages I and II are considered as early stage Hodgkin lymphoma and stages III and IV as advanced stage Hodgkin lymphoma. Using risk factors such as presence or absence of bulky disease, age, erythrocyte sedimentation rate and presence or absence of B symptoms, such as night sweats or fever, early stage Hodgkin lymphoma is further classified into early favourable and early unfavourable stages. Treatment options for Hodgkin lymphoma are chemotherapy, radiotherapy or chemotherapy plus radiotherapy. Nowadays chemotherapy plus radiotherapy to involved areas is considered as standard treatment for patients with early stage Hodgkin lymphoma. Radiotherapy has comparatively more treatment related late side effects than chemotherapy, including second malignancies. Perhaps, patients with early stage Hodgkin lymphoma can benefit more by avoiding radiotherapy and can be treated with chemotherapy alone as effectively as with same chemotherapy plus radiotherapy. With this assumption we assess the role of radiotherapy in the treatment of patients with early stage Hodgkin lymphoma. This systematic review compares chance of dying (overall survival) and chance of tumour control in patients with early stage Hodgkin lymphoma after receiving chemotherapy alone or chemotherapy plus radiotherapy. This review includes 1245 patients from five trials in the main analyses. The result of this review is that the addition of radiotherapy to six cycles of chemotherapy is a better treatment option than six cycles of same chemotherapy alone in patients with early stage Hodgkin lymphoma. In terms of five‐year tumour control, approximately 5 patients would be needed to treat with chemotherapy plus radiotherapy to prevent one additional relapse or progression in five years. For survival, 11 to 55 patients (depending on the risk of death) require treatment with additional radiotherapy to prevent one death in five years. Therefore chemotherapy plus radiotherapy (combined modality treatment) is superior to the identical chemotherapy alone in patients with early stage Hodgkin lymphoma.

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Terms to know

Cancer (Malignant Neoplasm)
A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body.
Lymph Nodes
A rounded mass of lymphatic tissue that is surrounded by a capsule of connective tissue. Lymph nodes filter lymph (lymphatic fluid), and they store lymphocytes (white blood cells). They are located along lymphatic vessels. Also called lymph gland.
Lymphatic System
The tissues and organs that produce, store, and carry white blood cells that fight infections and other diseases. This system includes the bone marrow, spleen, thymus, lymph nodes, and lymphatic vessels (a network of thin tubes that carry lymph and white blood cells). Lymphatic vessels branch, like blood vessels, into all the tissues of the body.
Lymphoid
Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop.
Lymphoma
Cancer that begins in cells of the immune system.
Reed-Sternberg Cells
A type of cell that appears in people with Hodgkin disease. The number of these cells increases as the disease advances.
Spleen
An organ that is part of the lymphatic system. The spleen makes lymphocytes, filters the blood, stores blood cells, and destroys old blood cells. It is located on the left side of the abdomen near the stomach.
Tissue
A group of cells that act together to carry out a specific function in the body. Examples include muscle tissue, nervous system tissue (including the brain, spinal cord, and nerves), and connective tissue (including ligaments, tendons, bones, and fat). Organs are made up of tissues.

More about Hodgkin Lymphoma

Photo of an adult woman

Also called: Hodgkin disease, Hodgkin's disease, Hodgkin's lymphoma, HL, HD

See Also: Non-Hodgkin Lymphoma

Other terms to know: See all 8
Cancer (Malignant Neoplasm), Lymph Nodes, Lymphatic System

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