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Psoriatic Arthritis

A type of arthritis associated with psoriasis, a chronic skin disease that occurs when cells in the outer layer of the skin reproduce faster than normal. NIH - National Institute of Arthritis and Musculoskeletal and Skin Diseases

About Psoriatic Arthritis

Psoriatic arthritis is a form of arthritis (joint inflammation) that can occur in people who have the skin disease psoriasis. Psoriasis is a common condition characterized by scaly red and white skin patches. Psoriatic arthritis can affect any joint in the body, including the spine.

Who is affected?

Anyone can be affected by psoriatic arthritis, but it is more common in Caucasians than African Americans or Asian Americans. It most commonly appears between the ages of 30 and 50, but it can also begin in childhood. According to the Centers for Disease Control and Prevention (CDC), 10 to 20 percent of people with psoriasis eventually develop psoriatic arthritis...Read more about Psoriatic Arthritis NIH - National Institute of Arthritis and Musculoskeletal and Skin Diseases

What works? Research summarized

Evidence reviews

Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis: a systematic review and economic evaluation

BACKGROUND: Etanercept, infliximab and adalimumab are licensed in the UK for the treatment of active and progressive psoriatic arthritis (PsA) in adults who have an inadequate response to standard treatment.

Risks and benefits of tumor necrosis factor-alpha inhibitors in the management of psoriatic arthritis: systematic review and metaanalysis of randomized controlled trials

This generally well-conducted review assessed the tumour necrosis factor-α (TNF-α) inhibitors adalimumab, etanercept and infliximab for the management of psoriatic arthritis (PsA). The authors concluded that TNF-α inhibitors were effective treatments for psoriatic arthritis with no important risks associated with short-term use. The conclusion reflected the results of the review and is likely to be reliable.

Risk and management of liver toxicity during methotrexate treatment in rheumatoid and psoriatic arthritis: a systematic review of the literature

The review concluded that serial abnormal liver enzyme tests in rheumatoid arthritis patients who took methotrexate might be associated with liver pathology, but that cirrhosis was relatively rare. Limitations in the reporting of the review suggest the authors' circumspect conclusions should nevertheless be interpreted with caution.

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Summaries for consumers

Medicines for Psoriatic Arthritis: A Review of the Research for Adults

This summary will tell you about DMARDs, a type of medicine for people with PsA. It will also discuss the possible side effects of these medicines. It will tell you what research has found about how well DMARDs work to treat PsA. This summary can help you talk with your doctor about whether one of these medicines might be right for you. This summary does not discuss treatments for the skin condition of psoriasis.

Interventions for treating psoriatic arthritis

It has been estimated that arthritis occurs in 5‐7 % of those with psoriasis, which can cause substantial disability in some patients.

Pain in patients with inflammatory arthritis and gastrointestinal or liver problems

This summary of a Cochrane review presents what we know from research about the effect of pain relieving drugs for people with inflammatory arthritis plus stomach or gut disease, or liver disease.

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More about Psoriatic Arthritis

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Other terms to know:
Arthritis, Psoriasis

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