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Chronic Myelogenous Leukemia (CML)

A slowly progressing disease in which too many white blood cells (not lymphocytes) are made in the bone marrow.

PubMed Health Glossary
(Source: NIH - National Cancer Institute)

About Chronic Myelogenous Leukemia (CML)

Chronic myelogenous leukemia is a disease in which the bone marrow makes too many white blood cells.

Chronic myelogenous leukemia (also called CML or chronic granulocytic leukemia) is a slowly progressing blood and bone marrow disease that usually occurs during or after middle age, and rarely occurs in children.

Leukemia may affect red blood cells, white blood cells, and platelets.

Normally, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. A lymphoid stem cell becomes a white blood cell... Read more about Chronic Myelogenous Leukemia

What works? Research summarized

Evidence reviews

Dasatinib and Nilotinib for Imatinib-Resistant or -Intolerant Chronic Myeloid Leukaemia: A Systematic Review and Economic Evaluation

Chronic myeloid leukaemia (CML) is a form of cancer affecting the blood, characterised by excessive proliferation of white blood cells in the bone marrow and circulating blood. In the UK, an estimated 560 new cases of CML are diagnosed each year.

Dasatinib, High-Dose Imatinib and Nilotinib for the Treatment of Imatinib-Resistant Chronic Myeloid Leukaemia: A Systematic Review and Economic Evaluation

The present report was commissioned as a supplement to an existing technology assessment report produced by the Peninsula Technology Assessment Group (PenTAG), which evaluated the clinical effectiveness and cost-effectiveness of dasatinib and nilotinib in patients who are either resistant or intolerant to standard-dose imatinib.

Systematic reviews on selected pharmacogenetic tests for cancer treatment: CYP2D6 for tamoxifen in breast cancer, KRAS for anti-EGFR antibodies in colorectal cancer, and BCR-ABL1 for tyrosine kinase inhibitors in chronic myeloid leukemia

Bibliographic details: Terasawa T, Dahabreh I, Castaldi PJ, Trikalinos TA.  Systematic reviews on selected pharmacogenetic tests for cancer treatment: CYP2D6 for tamoxifen in breast cancer, KRAS for anti-EGFR antibodies in colorectal cancer, and BCR-ABL1 for tyrosine kinase inhibitors in chronic myeloid leukemia. Rockville, MD, USA: Agency for Healthcare Research and Quality. Technology Assessment. 2010 Available from: http://www.cms.gov/medicare-coverage-database/details/technology-assessments-details.aspx?TAId=76&bc=BAAgAAAAAAAA&

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Summaries for consumers

Chronic Myelogenous Leukemia Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of chronic myelogenous leukemia.

Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of childhood acute lymphoblastic leukemia.

Nausea and Vomiting (PDQ®): Patient Version

Expert-reviewed information summary about nausea and vomiting as complications of cancer or its treatment. Approaches to the management of nausea and vomiting are discussed.

See all (19)

Terms to know

Blood
A tissue with red blood cells, white blood cells, platelets, and other substances suspended in fluid called plasma. Blood takes oxygen and nutrients to the tissues, and carries away wastes.
Bone Marrow
The soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.
Chronic
Refers to disorders that last a long time, often years. Chronic is the opposite of acute, or brief.
Granulocytes
A type of immune cell that has granules (small particles) with enzymes that are released during infections, allergic reactions, and asthma. Neutrophils, eosinophils, and basophils are granulocytes. A granulocyte is a type of white blood cell.
Lymphocytes
A lymphocyte is a type of white blood cell that is part of the immune system. There are two main types of lymphocytes: B cells and T cells. The B cells produce antibodies that are used to attack invading bacteria, viruses, and toxins. The T cells destroy the body's own cells that have themselves been taken over by viruses or become cancerous.
Lymphoid
Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop.
Myeloid
Having to do with or resembling the bone marrow. May also refer to certain types of hematopoietic (blood-forming) cells found in the bone marrow. Sometimes used as a synonym for myelogenous; for example, acute myeloid leukemia and acute myelogenous leukemia are the same disease.
Platelets (Thrombocytes)
A tiny piece of cell that is made by breaking off of a large cell in the bone marrow. Platelets are found in the blood and spleen. They help form blood clots to slow or stop bleeding, and to help wounds heal. Also called thrombocyte.
Red Blood Cells (Erythrocytes)
A cell that carries oxygen to all parts of the body.
Stem Cells
A cell from which other types of cells develop. For example, blood cells develop from blood-forming stem cells.
White Blood Cells (Leukocytes)
A type of immune cell. Most white blood cells are made in the bone marrow and are found in the blood and lymph tissue. White blood cells help the body fight infections and other diseases. Granulocytes, monocytes, and lymphocytes are white blood cells.

More about Chronic Myelogenous Leukemia

Photo of an adult

Also called: Chronic myeloid leukaemia, Chronic myelogenous leukaemia, Chronic granulocytic leukaemia, Chronic myelocytic leukaemia, Chronic granulocytic leukemia, Chronic myeloid leukemia, Chronic myelocytic leukemia

Other terms to know: See all 11
Blood, Bone Marrow, Chronic

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