Home > Health A – Z > Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML)

An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. NIH - National Cancer Institute

About Acute Myeloid Leukemia (AML)

Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets.

Adult acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. This type of cancer usually gets worse quickly if it is not treated. It is the most common type of acute leukemia in adults. AML is also called acute myelogenous leukemia, acute myeloblastic leukemia, acute granulocytic leukemia, and acute nonlymphocytic leukemia....Read more about Adult Acute Myeloid Leukemia

Childhood acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes a large number of abnormal blood cells.

Childhood acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. AML is also called acute myelogenous leukemia, acute myeloblastic leukemia, acute granulocytic leukemia, and acute nonlymphocytic leukemia. Cancers that are acute usually get worse quickly if they are not treated. Cancers that are chronic usually get worse slowly....Read more about Childhood Acute Myeloid Leukemia

What works? Research summarized

Evidence reviews

Treatment of acute myeloid leukemia in older patients: guideline recommendations

Bibliographic details: Zaretsky Y, Crump M, Haynes A E, Stevens A, Imrie K, Meyer R M, Hematology Disease Site Group.  Treatment of acute myeloid leukemia in older patients: guideline recommendations. This paper is produced by Cancer Care Ontario Practice Guidelines Initiative. The series is published on the Internet and regularly updated. To ensure that you are viewing the most up to date version, go to the Cancer Care Ontario website at: https://www.cancercare.on.ca/toolbox/qualityguidelines/ Available from: http://www.cancercare.on.ca/common/pages/UserFile.aspx?fileId=34529

Stem cell transplantation in adults with acute lymphoblastic leukaemia (ALL) or acute myeloid leukaemia (AML): Executive summary of final report N05-03A, Version 1.0

The aims of this review were the evaluation of studies on certain types of stem cell transplantation versus conventional chemotherapy in adults with acute lymphoblastic leukaemia (ALL) or acute myeloid leukaemia (AML); evaluation of studies on certain types of stem cell transplantation compared with each other in adults with ALL or AML.

Leukapheresis and low-dose chemotherapy do not reduce early mortality in acute myeloid leukemia hyperleukocytosis: a systematic review and meta-analysis

The role of leukapheresis and low-dose chemotherapy is unclear in decreasing early mortality in acute myeloid leukemia (AML) patients with hyperleukocytosis. This systematic review was conducted to describe early mortality (deaths during first induction) in patients with AML with an initial white blood count≥100×10(9)L(-1) stratified by the approach to leukapheresis and hydroxyurea/low-dose chemotherapy. Twenty-one studies were included. Weighted mean early deaths rate (20 studies, 1354 patients) was 20.1% (95% confidence interval 15.0-25.1). Neither leukapheresis strategy (p=0.67) nor hydroxyurea/low-dose chemotherapy (p=0.23) influenced the early death rate. Early mortality related to hyperleukocytosis in AML is not influenced by universal or selected use of leukapheresis or hydroxyurea/low-dose chemotherapy.

See all (63)

Summaries for consumers

Adult Acute Myeloid Leukemia Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of adult acute myeloid leukemia.

Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of childhood acute myeloid leukemia, myelodysplastic syndromes, and other myeloproliferative disorders.

Adult Acute Lymphoblastic Leukemia Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of adult acute lymphoblastic leukemia.

See all (27)

Terms to know

Acute
Describes something that happens suddenly and for a short time. Opposite of chronic, or long lasting.
Blood
A tissue with red blood cells, white blood cells, platelets, and other substances suspended in fluid called plasma. Blood takes oxygen and nutrients to the tissues, and carries away wastes.
Bone Marrow
The soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.
Granulocytes
A type of immune cell that has granules (small particles) with enzymes that are released during infections, allergic reactions, and asthma. Neutrophils, eosinophils, and basophils are granulocytes. A granulocyte is a type of white blood cell.
Leukemia
Cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the bloodstream.
Lymphoblasts
A lymphocyte that has gotten larger after being stimulated by an antigen. Lymphoblast also refers to an immature cell that can develop into a mature lymphocyte.
Lymphocytes
A lymphocyte is a type of white blood cell that is part of the immune system. There are two main types of lymphocytes: B cells and T cells. The B cells produce antibodies that are used to attack invading bacteria, viruses, and toxins. The T cells destroy the body's own cells that have themselves been taken over by viruses or become cancerous.
Lymphoid
Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop.
Myeloblasts
A type of immature white blood cell that forms in the bone marrow. Myeloblasts become mature white blood cells called granulocytes (neutrophils, basophils, and eosinophils).
Myeloid
Having to do with or resembling the bone marrow. May also refer to certain types of hematopoietic (blood-forming) cells found in the bone marrow. Sometimes used as a synonym for myelogenous; for example, acute myeloid leukemia and acute myelogenous leukemia are the same disease.
Stem Cells
A cell from which other types of cells develop. For example, blood cells develop from blood-forming stem cells.

More about Acute Myeloid Leukemia

Photo of an adult

Also called: Acute granulocytic leukaemia, Acute myeloblastic leukaemia, Acute myelocytic leukaemia, Acute myelogenous leukaemia, Acute myeloid leukaemia, Acute non-lymphocytic leukaemia, Acute granulocytic leukemia, Acute myeloblastic leukemia, Acute myelocytic leukemia, Acute myelogenous leukemia, Acute non-lymphocytic leukemia

Other terms to know: See all 11
Acute, Blood, Bone Marrow

Related articles:
Cancer: Anxiety and Distress

Keep up with systematic reviews on Acute Myeloid Leukemia:

RSS

PubMed Health Blog...

read all...