Home > Health A – Z > Glomerulonephritis

Glomerulonephritis

Inflammation of the glomeruli. Most often, it is caused by an autoimmune disease, but it can also result from infection. NIH - National Institute of Diabetes and Digestive and Kidney Diseases

About Glomerulonephritis

Many diseases affect kidney function by attacking the glomeruli, the tiny units within the kidney where blood is cleaned. Glomerular diseases include many conditions with a variety of genetic and environmental causes, but they fall into two major categories:

Although glomerulonephritis and glomerulosclerosis have different causes, they can both lead to kidney failure.

How do glomerular diseases interfere with kidney function?

Glomerular diseases damage the glomeruli, letting protein and sometimes red blood cells leak into the urine. Sometimes a glomerular disease also interferes with the clearance of waste products by the kidney, so they begin to build up in the blood. Furthermore, loss of blood proteins like albumin in the urine can result in a fall in their level in the bloodstream. In normal blood, albumin acts like a sponge, drawing extra fluid from the body into the bloodstream, where it remains until the kidneys remove it. But when albumin leaks into the urine, the blood loses its capacity to absorb extra fluid from the body. Fluid can accumulate outside the circulatory system in the face, hands, feet, or ankles and cause swelling... Read more about glomerular diseases NIH - National Institute of Diabetes and Digestive and Kidney Diseases

What works? Research summarized

Evidence reviews

Effect of interferon-alpha-based antiviral therapy on hepatitis C virus-associated glomerulonephritis: a meta-analysis

Bibliographic details: Feng B, Eknoyan G, Guo ZS, Jadoul M, Rao HY, Zhang W, Wei L.  Effect of interferon-alpha-based antiviral therapy on hepatitis C virus-associated glomerulonephritis: a meta-analysis. Nephrology Dialysis Transplantation 2012; 27(2): 640-646

The efficacy of anti-viral therapy on hepatitis b virus-associated glomerulonephritis: a systematic review and meta-analysis

OBJECTIVES: To assess the efficacy of anti-viral therapy on hepatitis B virus associated glomerulonephritis (HBV-GN).

Plasma exchange for renal vasculitis and idiopathic rapidly progressive glomerulonephritis: a meta-analysis

BACKGROUND: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis.

See all (51)

Summaries for consumers

Hydralazine for treatment of high blood pressure

Hydralazine has been used for the treatment of high blood pressure since the 1950's. It is believed that hydralazine reduces blood pressure, however there are concerns due to the potential for this drug to cause adverse effects. The aim of this review was to determine the extent to which hydralazine reduces blood pressure, the nature of hydralazine’s adverse effect profile, and to determine the clinical impact of its use for hypertension. Unfortunately, the search revealed no randomized controlled trials which compared hydralazine to placebo as monotherapy for primary hypertension, therefore we are unable to make firm conclusions regarding its effects on blood pressure, adverse effects, or clinical outcomes. Some of the adverse effects related to hydralazine and that have been reported in the literature include reflex tachycardia, hemolytic anemia, vasculitis, glomerulonephritis, and a lupus‐like syndrome.

Interventions for renal vasculitis in adults

Renal vasculitis presents as rapidly progressive glomerulonephritis which is a form of kidney disease that causes damage to the small structures (glomeruli) inside the kidneys that help filter waste and fluids from blood to form urine. The disease leads to a rapid loss of kidney function. Standard immunosuppression with steroids and cyclophosphamide (CPA) is recommended. The aim of this review was to evaluate the benefits and harms of any intervention for the treatment of renal vasculitis. Thirteen studies (702 patients) were identified. Plasma exchange reduces the risk of end‐stage kidney disease in patients presenting with severe acute kidney failure. The use of pulse CPA results in good remission rates but an increased risk of relapse. AZA is effective as maintenance therapy once remission has been achieved.

Different antibiotics for group A streptococcal pharyngitis

Pharyngitis or tonsillitis, a throat infection that usually presents with a sore throat, is a common upper respiratory tract infection. Most sore throats are caused by viruses, but sometimes bacteria are involved. Many people carry bacteria in their throat without becoming ill. However, sometimes a bacterial throat infection can occur.

See all (6)

Terms to know

Autoimmune Disease
Disease that results when the immune system mistakenly attacks the body's own tissues. Examples include multiple sclerosis, type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus.
Glomerular Filtration Rate
The rate at which the kidneys filter wastes and extra fluid from the blood, measured in milliliters per minute.
Glomeruli
A tiny set of looping blood vessels in the nephron where blood is filtered in the kidney. Plural of glomerulus.
Glomerulosclerosis
Scarring of the glomeruli. It may result from diabetes (diabetic glomerulosclerosis) or from deposits in parts of the glomeruli (focal segmental glomerulosclerosis). The most common signs of glomerulosclerosis are proteinuria and chronic kidney disease.
Nephrons
A tiny part of the kidneys. Each kidney is made up of about 1 million nephrons, which are the working units of the kidneys, removing wastes and extra fluids from the blood.
Nephrotic Syndrome
A collection of symptoms that indicate kidney damage. Symptoms include high levels of protein in the urine, lack of protein in the blood, and high blood cholesterol.

More about Glomerulonephritis

Photo of an adult

Also called: GN

Other terms to know: See all 6
Autoimmune Disease, Glomerular Filtration Rate, Glomeruli

Related articles:
How the Kidneys Work

Keep up with systematic reviews on Glomerulonephritis:

RSS

PubMed Health Blog...

read all...