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Chronic Hepatitis

An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders.

PubMed Health Glossary
(Source: NIH - National Cancer Institute)

What works? Research summarized

Evidence reviews

The comparative clinical effectiveness and value of simeprevir and sofosbuvir in the treatment of chronic hepatitis C infection

Bibliographic details: Tice JA, Ollendorf DA, Pearson SD.  The comparative clinical effectiveness and value of simeprevir and sofosbuvir in the treatment of chronic hepatitis C infection. Institute for Clinical and Economic Review. 201424798321

Kushenin for chronic hepatitis B: a systematic review

Bibliographic details: Wang S L, Yao N L, Lv W L, Wu T X.  Kushenin for chronic hepatitis B: a systematic review. Chinese Journal of Evidence-Based Medicine 2008; 8(2): 102-119

Polyunsaturated phosphatidylcholine (essentiale) for chronic hepatitis: a systematic review

Bibliographic details: Hu G P, Liu K, Wang S, Tang H, Zhao L S.  Polyunsaturated phosphatidylcholine (essentiale) for chronic hepatitis: a systematic review. Chinese Journal of Evidence-Based Medicine 2005; 5(7): 543-548

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Summaries for consumers

Chronic hepatitis C: What are the advantages or disadvantages of boceprevir (Victrelis)?: People with chronic hepatitis C who have not responded to previous treatment or who have had a recurrence

This text summarizes the effects of boceprvir for people with chronic hepatitis C who have not responded to previous treatment or who have had a recurrence. IQWiG assessed trials that compared triple therapy consisting of boceprevir and the previous standard drugs peginterferon alfa and ribavirin, with dual standard therapy consisting only of peginterferon alfa and ribavirin.

Chronic hepatitis C: What are the advantages or disadvantages of boceprevir (Victrelis)?: Boceprevir for people with chronic hepatitis C who have not been treated before

This text summarizes the effects of Boceprevir for people with chronic hepatitis C who have not been treated before. IQWiG assessed trials that compared triple therapy consisting of boceprevir and the previous standard drugs peginterferon alfa and ribavirin, with dual standard therapy consisting only of peginterferon alfa and ribavirin.

Simeprevir (Olysio) for chronic hepatitis C: Simeprevir (Olysio) for hepatitis C (genotype 1) that has been treated unsuccessfully

In 2014, the Institute for Quality and Efficiency in Health Care (IQWiG, Germany) assessed the advantages and disadvantages of simeprevir in combination with peginterferon and ribavirin in treating chronic hepatitis C compared with standard therapies.The following results apply to people with chronic HCV infection who have previously been treated unsuccessfully and are not infected with HIV. One of the studies compared the drug simeprevir with telaprevir. Both drugs were used in combination with peginterferon alfa and ribavirin.

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More about Chronic Hepatitis

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Other terms to know:
Autoimmune Disease, Metabolic Disorders

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