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Epilepsy

A group of disorders marked by problems in the normal functioning of the brain. These problems can produce seizures, unusual body movements, a loss of consciousness or changes in consciousness, as well as mental problems or problems with the senses.

PubMed Health Glossary
(Source: NIH - National Cancer Institute)

About Epilepsy

The epilepsies are a spectrum of brain disorders ranging from severe, life-threatening and disabling, to ones that are much more benign.

In epilepsy, the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior or sometimes convulsions, muscle spasms, and loss of consciousness.

The epilepsies have many possible causes and there are several types of seizures. Anything that disturbs the normal pattern of neuron activity—from illness to brain damage to abnormal brain development—can lead to seizures. Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters, changes in important features of brain cells called channels, or some combination of these and other factors.

Having a single seizure as the result of a high fever (called febrile seizure) or head injury does not necessarily mean that a person has epilepsy. Only when a person has had two or more seizures is he or she considered to have epilepsy.

A measurement of electrical activity in the brain and brain scans such as magnetic resonance imaging or computed tomography are common diagnostic tests for epilepsy. NIH - National Institute of Neurological Disorders and Stroke

What works? Research summarized

Evidence reviews

Care delivery and self‐management strategies for children with epilepsy

Evidence for the best ways to care for children with epilepsy is still unclear.

Non‐pharmacological interventions for epilepsy in people with intellectual disabilities

This review identified the lack of any randomised controlled trials (RCTs) for non‐pharmacological interventions in people with epilepsy and intellectual disabilities. There is evidently a need for well‐designed RCTs to ascertain the effects of non‐pharmacological interventions on seizure and behavioural outcomes in this population. However, good quality RCT evidence in the non‐intellectually disabled should be assessed for the side effect and efficacy profile prior before undertaking such studies.

Clobazam as an add‐on in the management of refractory epilepsy

Only four randomised controlled trials have been undertaken assessing add‐on clobazam for refractory epilepsy. All are cross‐over studies of short duration; they used differing designs and were of poor methodological quality. Results suggest that clobazam reduces seizure frequency for drug refractory partial epilepsy. There are limited and inconclusive data for generalized epilepsy. Cloabazam was also associated with adverse events.

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Summaries for consumers

Perampanel (Fycompa) for epilepsy: Overview

Perampanel (trade name: Fycompa) has been approved since July 2012 as an add-on therapy for epileptic seizures in adults and children over the age of 12.

Care delivery and self‐management strategies for children with epilepsy

Evidence for the best ways to care for children with epilepsy is still unclear.

Non‐pharmacological interventions for epilepsy in people with intellectual disabilities

This review identified the lack of any randomised controlled trials (RCTs) for non‐pharmacological interventions in people with epilepsy and intellectual disabilities. There is evidently a need for well‐designed RCTs to ascertain the effects of non‐pharmacological interventions on seizure and behavioural outcomes in this population. However, good quality RCT evidence in the non‐intellectually disabled should be assessed for the side effect and efficacy profile prior before undertaking such studies.

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Terms to know

Brain
The part of the central nervous system that is contained within the skull (cranium).
Imaging Tests
A type of test that makes pictures of areas inside the body. Some examples of imaging tests are CT scans and MRIs. Also called imaging procedure.
Neurotransmitters
A chemical that is made by nerve cells and used to communicate with other cells, including other nerve cells and muscle cells.
Seizures
Sudden, uncontrolled body movements and changes in behavior that occur because of abnormal electrical activity in the brain. Symptoms include loss of awareness, changes in emotion, loss of muscle control, and shaking. Seizures may be caused by drugs, high fevers, head injuries, and certain diseases, such as epilepsy.

More about Epilepsy

Photo of a young adult

Also called: Epileptic attack, Epileptic convulsions, Epileptic disorder, Epileptic fits, Epileptic seizures, Epileptic, Seizure disorder, EP

Other terms to know: See all 4
Brain, Imaging Tests, Neurotransmitters

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