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Tuberous Sclerosis

A genetic disorder in which benign (not cancer) tumors form in the kidneys, brain, eyes, heart, lungs, and skin. This disease can cause seizures, mental disabilities, and different types of skin lesions.

PubMed Health Glossary
(Source: NIH - National Cancer Institute)

What works? Research summarized

Evidence reviews

Efficacy and safety of sirolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: a systematic review

PURPOSE: We evaluate the efficacy and safety of sirolimus in the treatment of renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.

Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis

The authors concluded that melatonin decreased sleep latency and the number of wakes per night and increased total sleep time in people with intellectual disabilities. These conclusions appeared supported by the evidence, but the limited search and incomplete reporting of review methods made it difficult to assess their reliability.

The Epilepsies: The Diagnosis and Management of the Epilepsies in Adults and Children in Primary and Secondary Care: Pharmacological Update of Clinical Guideline 20

This guideline is a partial update of ‘The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care’ (NICE clinical guideline 20, 2004). It updates the pharmacological management sections of the 2004 guideline and also includes the use of the ketogenic diet.

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Summaries for consumers

Treatment of infantile spasms

The optimum treatment for infantile spasms has yet to be proven with confidence, in part because of the different aims of existing studies. However, some useful conclusions can be drawn from current evidence.

Childhood Astrocytomas Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of childhood astrocytomas.

Adult Soft Tissue Sarcoma Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of adult soft tissue sarcoma.

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More about Tuberous Sclerosis

Photo of a child

Also called: Adenoma sebaceum syndrome, Tuberose sclerosis, Tuberous sclerosis complex, Tuberous sclerosis syndrome, TS, TSC

Other terms to know:
Genetic, Lesion, Seizures

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