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The presence of elevated levels of uric acid in the blood. NIH - National Institute of Arthritis and Musculoskeletal and Skin Diseases

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Evidence reviews

[Irbesartan for hypertensive patients with hyperuricaemia: a systematic review]

Bibliographic details: Wu FB, Zhan M, Tang Y.  [Irbesartan for hypertensive patients with hyperuricaemia: a systematic review]. Chinese Journal of Evidence-Based Medicine 2011; 11(11): 1290-1294

Effects of urate-lowering therapy in hyperuricemia on slowing the progression of renal function: a meta-analysis

Uric acid (UA) is generally regarded as an independent risk factor for poor prognosis of patients with kidney disease. However, urate-lowering therapy (ULT) in asymptomatic hyperuricemia is conservative. Whether the beneficial effect on renal function can be achieved by lowering UA remains uncertain. A compound search for randomized controlled trials was conducted in databases consisting of MEDLINE, EMBASE, the Cochrane Library, the Chinese Biomedical Literature Database, and Chinese Science and Technology periodical databases. Two investigators independently screened these studies, assessed the included trials, and extracted data. Eleven articles with a total number of 753 participants met the criteria and were included in our meta-analysis. The results showed that ULT was associated with a decrease in serum creatinine and an increase in eGFR. Our study further confirms that ULT may have beneficial effects on slowing the progression of renal function.

Effects of hyperuricemia on renal function of renal transplant recipients: a systematic review and meta-analysis of cohort studies

BACKGROUND: Hyperuricemia is an independent risk factor of nephropathy, but its role in renal transplant recipients (RTRs) is controversial.

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Summaries for consumers

Pharmacotherapy for hyperuricemia in hypertensive patients

Uric acid results from the breakdown of purines, which are part of all human tissues and found in protein containing foods. Increased dietary ingestion of purine‐containing foods or decreased uric acid excretion lead to high uric acid serum levels (hyperuricemia). High blood pressure is a major health matter worldwide. The observation of the relationship between hyperuricemia and hypertension dates back to the 19th century. Today, there is more evidence that this is an important association. The aim of this review is to evaluate if lowering serum uric acid also lowers blood pressure. It might represent a new goal and/or a therapeutic option for hypertension. Three hundred and thirty‐six studies were examined and only one study matched the criteria for inclusion in this review. The study enrolled 30 adolescents (11 ‐ 17 years) with newly diagnosed high blood pressure and with high serum uric acid levels, and showed that allopurinol decreased blood pressure. No adverse events were seen in patients treated with allopurinol. However, the number of patients providing data on pharmacotherapy for hyperuricemia in hypertension is small and restricted to adolescents with recently diagnosed mild hypertension. Hence, there is insufficient evidence to recommend the use of allopurinol or other drugs that lower uric acid in the management of patients with hypertension. More research on this question is needed.

Pegloticase for chronic gout

‐        it is unknown whether pegloticase can improve the pain and function of people with chronic gout.

Zinc supplementation for the prevention of type 2 diabetes mellitus

Currently no evidence to suggest the use of zinc for the primary prevention of type 2 diabetes. Diabetes mellitus is associated with long‐term complications, especially eye, kidney, nerve, heart and blood vessel disease. Type 2 diabetes is mainly characterised by a reduced ability of the hormone insulin to stimulate glucose uptake in body fat and muscles (insulin resistance) and affects most people suffering from diabetes. Type 2 diabetes may not cause symptoms for some time and may remain undetected for many years. Zinc, an important mineral, plays a relevant role in the synthesis and action of insulin. The human body does not produce zinc on its own, so it must be obtained from outside sources. The mineral zinc can be found in both animal and plant food sources, but the richest source of zinc comes from animal food sources.

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More about Hyperuricemia

Photo of an adult

Also called: Hyperuricaemia, Uricacidaemia, Uricacidemia

See Also: Gout

Other terms to know:
Uric Acid

Keep up with systematic reviews on Hyperuricemia:


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