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Hyperuricemia

The presence of elevated levels of uric acid in the blood.

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(Source: NIH - National Institute of Arthritis and Musculoskeletal and Skin Diseases)

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Pharmacotherapy for hyperuricemia in hypertensive patients

Uric acid results from the breakdown of purines, which are part of all human tissues and found in protein containing foods. Increased dietary ingestion of purine‐containing foods or decreased uric acid excretion lead to high uric acid serum levels (hyperuricemia). High blood pressure is a major health matter worldwide. The observation of the relationship between hyperuricemia and hypertension dates back to the 19th century. Today, there is more evidence that this is an important association. The aim of this review is to evaluate if lowering serum uric acid also lowers blood pressure. It might represent a new goal and/or a therapeutic option for hypertension. Three hundred and thirty‐six studies were examined and only one study matched the criteria for inclusion in this review. The study enrolled 30 adolescents (11 ‐ 17 years) with newly diagnosed high blood pressure and with high serum uric acid levels, and showed that allopurinol decreased blood pressure. No adverse events were seen in patients treated with allopurinol. However, the number of patients providing data on pharmacotherapy for hyperuricemia in hypertension is small and restricted to adolescents with recently diagnosed mild hypertension. Hence, there is insufficient evidence to recommend the use of allopurinol or other drugs that lower uric acid in the management of patients with hypertension. More research on this question is needed.

Irbesartan for hypertensive patients with hyperuricaemia: a systematic review

Bibliographic details: Wu FB, Zhan M, Tang Y.  Irbesartan for hypertensive patients with hyperuricaemia: a systematic review. Chinese Journal of Evidence-Based Medicine 2011; 11(11): 1290-1294

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Summaries for consumers

Pharmacotherapy for hyperuricemia in hypertensive patients

Uric acid results from the breakdown of purines, which are part of all human tissues and found in protein containing foods. Increased dietary ingestion of purine‐containing foods or decreased uric acid excretion lead to high uric acid serum levels (hyperuricemia). High blood pressure is a major health matter worldwide. The observation of the relationship between hyperuricemia and hypertension dates back to the 19th century. Today, there is more evidence that this is an important association. The aim of this review is to evaluate if lowering serum uric acid also lowers blood pressure. It might represent a new goal and/or a therapeutic option for hypertension. Three hundred and thirty‐six studies were examined and only one study matched the criteria for inclusion in this review. The study enrolled 30 adolescents (11 ‐ 17 years) with newly diagnosed high blood pressure and with high serum uric acid levels, and showed that allopurinol decreased blood pressure. No adverse events were seen in patients treated with allopurinol. However, the number of patients providing data on pharmacotherapy for hyperuricemia in hypertension is small and restricted to adolescents with recently diagnosed mild hypertension. Hence, there is insufficient evidence to recommend the use of allopurinol or other drugs that lower uric acid in the management of patients with hypertension. More research on this question is needed.

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More about Hyperuricemia

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Also called: Hyperuricaemia, Uricacidaemia, Uricacidemia

See Also: Gout

Other terms to know:
Uric Acid

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