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Fanconi Anemia

Fanconi anemia, or FA, is a rare, inherited blood disorder that leads to bone marrow failure. The disorder also is called Fanconi's anemia.

PubMed Health Glossary
(Source: NIH - National Heart, Lung, and Blood Institute)

Fanconi Anemia

Fanconi anemia (fan-KO-nee uh-NEE-me-uh), or FA, is a rare, inherited blood disorder that leads to bone marrow failure. The disorder also is called Fanconi's anemia.

FA prevents your bone marrow from making enough new blood cells for your body to work normally. FA also can cause your bone marrow to make many faulty blood cells. This can lead to serious health problems, such as leukemia (a type of blood cancer).

Although FA is a blood disorder, it also can affect many of your body's organs, tissues, and systems. Children who inherit FA are at higher risk of being born with birth defects. FA also increases the risk of some cancers and other serious health problems.

FA is different from Fanconi syndrome. Fanconi syndrome affects the kidneys. It's a rare and serious condition that mostly affects children.

Children who have Fanconi syndrome pass large amounts of key nutrients and chemicals through... Read more about Fanconi Anemia

What works? Research summarized

Evidence reviews

Hematopoietic Stem-Cell Transplantation in the Pediatric Population [Internet]

Assess comparative benefits and harms of hematopoietic stem-cell transplantation (HSCT) versus standard therapies or disease natural history in pediatric (age ≤21 years) patients with malignant solid tumors, inherited metabolic diseases, or autoimmune diseases.

Heavy Menstrual Bleeding

Heavy menstrual bleeding (HMB) has an adverse effect on the quality of life of many women. It is not a problem associated with significant mortality. Many women seek help from their general practitioners and it is a common reason for referral into secondary care.

ATG plus cyclosporine reduces all-cause mortality in patients with severe aplastic anemia: systematic review and meta-analysis

The authors concluded that a combination of antithymocyte globulin and cyclosporine reduced short- and long-term mortality in patients with newly diagnosed severe aplastic anaemia compared to antithymocyte globulin alone. Effects on non-severe aplastic anaemia remained unclear. In view of the small number and questionable quality of the included studies, a degree of caution may be advisable in interpreting these findings.

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Summaries for consumers

Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of childhood acute myeloid leukemia, myelodysplastic syndromes, and other myeloproliferative disorders.

Childhood Central Nervous System Embryonal Tumors Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of childhood medulloblastoma and childhood supratentorial primitive neuroectodermal and pineal tumors.

Terms to know

A condition caused when the body does not have enough red blood cells or hemoglobin. Hemoglobin is a protein in the blood that carries oxygen.
Blood Plasma
The clear, yellowish, fluid part of the blood that carries the blood cells. The proteins that form blood clots are in plasma.
Bone Marrow
The soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.
Inherited; having to do with information that is passed from parents to offspring through genes in sperm and egg cells.
A protein inside red blood cells that carries oxygen from the lungs to tissues and organs in the body and carries carbon dioxide back to the lungs.
Platelets (Thrombocytes)
A tiny piece of cell that is made by breaking off of a large cell in the bone marrow. Platelets are found in the blood and spleen. They help form blood clots to slow or stop bleeding, and to help wounds heal. Also called thrombocyte.
Red Blood Cells (Erythrocytes)
A cell that carries oxygen to all parts of the body.
White Blood Cells (Leukocytes)
A type of immune cell. Most white blood cells are made in the bone marrow and are found in the blood and lymph tissue. White blood cells help the body fight infections and other diseases. Granulocytes, monocytes, and lymphocytes are white blood cells.

More about Fanconi Anemia

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Also called: Fanconi anaemia, Fanconi's anemia, FA

See Also: Bone Marrow

Other terms to know: See all 8
Anemia, Blood Plasma, Bone Marrow

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