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Lung Cancer

Cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer. These types are diagnosed based on how the cells look under a microscope.

PubMed Health Glossary
(Source: NIH - National Cancer Institute)

About Lung Cancer

Non-Small Cell Lung Cancer

A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer... Read more about Non-Small Cell Lung Cancer

Small Cell Lung Cancer

An aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope... Read more about Small Cell Lung Cancer

What works? Research summarized

Evidence reviews

Referral Guidelines for Suspected Cancer in Adults and Children [Internet]

The guideline is divided into sections which cover in detail specific topics relating to twelve groups of cancers: lung, upper gastrointestinal cancers, lower gastrointestinal cancers, breast cancer, gynaecological cancers, urological cancers, haematological cancers, skin cancers, head and neck including oral cancers, brain/central nervous system cancers, bone and sarcoma, and children’s and young people’s cancers.

[CT screening for lung cancer: systematic review]

Bibliographic details: Vidal Serrano S, Mendez A L.  [CT screening for lung cancer: systematic review]. [Cribado de cancer de pulmon con TC de torax: revision sistematica.] Medicina Clinica 2007; 129(15): 582-58717988617

Topotecan for small cell lung cancer: a systematic review

Bibliographic details: Wang X-S, Wu T-X, Hou M.  Topotecan for small cell lung cancer: a systematic review. Chinese Journal of Evidence-Based Medicine 2007; 7(3): 189-203

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Summaries for consumers

Afatinib (Giotrif) for advanced lung cancer: Overview

Afatinib (trade name: Giotrif) has been approved in Germany since September 2013 for the treatment of a specific type of advanced lung cancer. It can be used in adult patients who have mutated cancer cells that can lead to faster tumor growth.

Afatinib (Giotrif) for advanced lung cancer: Afatinib for L858R EGFR mutations

In early 2014, the Institute for Quality and Efficiency in Health Care (IQWiG, Germany) assessed the advantages and disadvantages of afatinib in adults with advanced lung cancer and a mutated EGF receptor. One relevant trial was provided by the manufacturer: One group was given afatinib, the other was given a fixed combination of cisplatin and pemetrexed.The following results apply to patients whose tumor has a L858R mutation of the EGF receptor.

Afatinib (Giotrif) for advanced lung cancer: Afatinib for other EGF receptor mutations

In early 2014, the Institute for Quality and Efficiency in Health Care (IQWiG) assessed the advantages and disadvantages of afatinib in adults with advanced lung cancer and a mutated EGF receptor. One relevant trial was provided by the manufacturer: One group was given afatinib, the other was given a fixed combination of cisplatin and pemetrexed.The following results apply to patients whose tumor has neither a Del19 mutation, nor a L858R mutation of the EGF receptor.

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Terms to know

Lungs
One of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body.
Non-Small Cell Lung Cancer
A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer.
Small Cell Lung Cancer
An aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope.
Squamous Cell Carcinoma
Cancer that begins in squamous cells. Squamous cells are thin, flat cells that look like fish scales, and are found in the tissue that forms the surface of the skin, the lining of the hollow organs of the body, and the lining of the respiratory and digestive tracts.

More about Lung Cancer

Photo of an adult

Also called: Malignant tumour of the lung, Malignant tumor of the lung

Other terms to know: See all 4
Lungs, Non-Small Cell Lung Cancer, Small Cell Lung Cancer

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