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Sofosbuvir (By mouth)

Treats hepatitis C. Used together with ribavirin, with or without peginterferon-alfa.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Sofosbuvir is used in combination with ribavirin (Copegus®, Rebetol®) with or without injectable peginterferon alfa (Pegasys®, Pegintron®) to treat chronic hepatitis C infection. This medicine is available only with your doctor's prescription… Read more
Brand names include
Sovaldi
Drug classes About this
Antiviral

What works? Research summarized

Evidence reviews

The comparative clinical effectiveness and value of simeprevir and sofosbuvir in the treatment of chronic hepatitis C infection

Bibliographic details: Tice JA, Ollendorf DA, Pearson SD.  The comparative clinical effectiveness and value of simeprevir and sofosbuvir in the treatment of chronic hepatitis C infection. Institute for Clinical and Economic Review. 2014

Sofosbuvir (Sovaldi): Sofosbuvir is Indicated for the Treatment of Chronic Hepatitis C Virus (CHC) Infection in Adult Patients With Compensated Liver Disease, Including Cirrhosis [Internet]

Objective: To perform a systematic review of the beneficial and harmful effects of sofosbuvir in combination with other agents for the treatment of adults with chronic hepatitis C virus (CHC) infection (genotypes 1, 2, 3, or 4).

Interferon-free Regimens for Genotype 1 Chronic Hepatitis C: A Review of the Clinical Evidence and Cost-Effectiveness [Internet]

In Canada it is estimated that 242,000 Canadians have chronic hepatitis C virus (HCV) infection; however, the exact number affected is unknown as 30% to 70% of patients are unaware that they are infected. Fifteen to 25% of patients with chronic infection will develop hepatocellular carcinoma, progressive liver disease, end-stage liver disease, or will require a liver transplant over 20 to 30 years of infection. There are six major HCV genotypes, and genotype 1 accounts for approximately 60% of HCV infections in Canadians.

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