Home > Drugs A – Z > Nicotine (Into the mouth)
  • We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Nicotine (Into the mouth)

Helps you quit smoking by reducing nicotine cravings. Provides your body with nicotine to replace cigarettes.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Brand names include
Commit, Equate Nicotine, Good Neighbor Pharmacy Nicotine, Good Neighbor Pharmacy Nicotine Gum, Good Neighbor Pharmacy Nicotine Polacrilex, Good Sense Nicotine Polacrilex, Leader Nicotine Polacrilex, Leader Nicotine Polacrilex Gum, Nicorelief, Nicorette, Rite Aid Mini Nicotine, Rite Aid Nicotine, Rite Aid Nicotine Polacrilex, Sunmark Nicotine, Sunmark Nicotine Lozenge
Other forms
Absorbed through the skin, By breathing, Into the nose
Drug classes About this
Smoking Cessation Agent

What works? Research summarized

Evidence reviews

Does use of nicotine replacement therapy while continuing to smoke undermine cessation? A systematic review

Bibliographic details: Beard E, Aveyard P, Michie S, McNeill A, West R.  Does use of nicotine replacement therapy while continuing to smoke undermine cessation? A systematic review. Journal of Smoking Cessation 2013; 8(1): 45-56

Using nicotine replacement therapy to assist in reducing cigarette consumption before quitting: another strategy for smoking cessation?

This review, which assessed the efficacy of nicotine replacement therapy (NRT) in reducing cigarette consumption in smokers before quitting, concluded that NRT is effective and can lead to long-term cessation, which should remain the ultimate goal. Given several limitations of the review (such as potential reviewer bias), and the limited study details and data synthesis, the authors' conclusions may not be reliable.

Meta-analysis study for one year effects of a nicotine patch

The review evaluated the long-term efficacy of the nicotine patch in smoking cessation and found that nicotine patches significantly increased the success rate for smoking cessation after one year. Lack of reporting of review methods and assessment of trial quality, in addition to evidence for possible publication bias, makes the reliability of the authors? conclusion unclear.

See all (171)

Summaries for consumers

Quitting smoking: How much do nicotine patches and gum help?

Nicotine replacement products increase the chances of quitting smoking, but it usually takes more than one attempt.

Fact sheet: Nicotine replacement therapy for quitting smoking

Many people find it difficult to quit smoking. It usually takes several attempts to successfully quit, and support is often needed. Nicotine replacement therapy (NRT) can help to reduce the symptoms of withdrawal.

No evidence of the efficacy of nicotine for Alzheimer's disease

Nicotine has been related to recovery of memory in humans and animal models and some observational studies have been compatible with a protective effect of nicotine inhalation against Alzheimer's disease. At present, there is great controversy over this possible effect of tobacco use, and evidence is inconclusive. This review found no evidence on which to recommend nicotine for Alzheimer's disease.

See all (62)

PubMed Health Blog...

read all...