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Cysteamine (Into the eye)

Treats cystine crystal buildup in the cornea of patients who have cystinosis.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Cysteamine eye drops is used to treat cystine crystal buildup in the cornea (front part of the eye) of patients with cystinosis. Cystinosis is a hereditary disorder that causes an accumulation of the amino acid cystine within cells, forming crystals that can build up and damage the eyes. This medicine works by removing the extra cystine from the cornea. This medicine is available only with your… Read more
Brand names include
Cystaran
Other forms
By mouth
Drug classes About this
Ophthalmologic Agent

What works? Research summarized

Evidence reviews

Evidence on interventions for paracetamol (acetaminophen) overdose patients is weak

Poisoning with paracetamol (acetaminophen) is a common cause of hepatic injury. The evidence for all interventions for paracetamol overdose is weak. Activated charcoal, gastric lavage, and ipecacuanha are able to reduce absorption of paracetamol if started within one to two hours of paracetamol ingestion, but the clinical benefit is unclear. Activated charcoal seems to be the best choice if the patient is compliant. N‐acetylcysteine seems superior to no intervention and other antidotes (dimercaprol, cysteamine) and should be administered to patients at significant risk of hepatic damage. However, N‐acetylcysteine superiority to methionine is unclear. Liver transplantation will clearly benefit patients with irreversible hepatic failure. However, identifying such patients early is problematic and the long‐term outcomes in this group of patients have not been reported. Other interventions have not shown any clinical benefit for paracetamol overdose.

Self-Harm: The Short-Term Physical and Psychological Management and Secondary Prevention of Self-Harm in Primary and Secondary Care

This guideline has been developed to advise on the short-term physical and psychological management and secondary prevention of self-harm in primary and secondary care. The guideline recommendations have been developed by a multidisciplinary group of healthcare professionals, patients and their representatives, and researchers after careful consideration of the best available evidence. It is intended that the guideline will be useful to clinicians and service commissioners in providing and planning high quality care for those people who self-harm while also emphasising the importance of the experience of care for service users and carers.

Review article: the management of paediatric nonalcoholic fatty liver disease

BACKGROUND: Paediatric nonalcoholic fatty liver disease (NAFLD) is a major public health concern given the recent increase in its prevalence and link to obesity and other metabolic comorbidities. Current treatment strategies involve lifestyle changes. Other surgical and pharmacologic interventions have been proposed; however, limited randomised controlled trials (RCTs) in the paediatric population restrict their use.

Summaries for consumers

Evidence on interventions for paracetamol (acetaminophen) overdose patients is weak

Poisoning with paracetamol (acetaminophen) is a common cause of hepatic injury. The evidence for all interventions for paracetamol overdose is weak. Activated charcoal, gastric lavage, and ipecacuanha are able to reduce absorption of paracetamol if started within one to two hours of paracetamol ingestion, but the clinical benefit is unclear. Activated charcoal seems to be the best choice if the patient is compliant. N‐acetylcysteine seems superior to no intervention and other antidotes (dimercaprol, cysteamine) and should be administered to patients at significant risk of hepatic damage. However, N‐acetylcysteine superiority to methionine is unclear. Liver transplantation will clearly benefit patients with irreversible hepatic failure. However, identifying such patients early is problematic and the long‐term outcomes in this group of patients have not been reported. Other interventions have not shown any clinical benefit for paracetamol overdose.

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