Home > Drugs A – Z > Ropinirole (By mouth)

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Ropinirole is used alone or with other medicines to treat Parkinson's disease. Ropinirole tablets are also used to treat a condition called Restless Legs Syndrome (RLS). RLS is a neurologic disorder that affects sensation and movement in the legs and causes the legs to feel uncomfortable. This results in an overwhelming feeling of wanting to move your legs to make them comfortable. This medicine… Read more
Brand names include
Requip, Requip XL
Drug classes About this
Antiparkinsonian

What works? Research summarized

Evidence reviews

A mixed treatment comparison of gabapentin enacarbil, pramipexole, ropinirole and rotigotine in moderate-to-severe restless legs syndrome

OBJECTIVE: A mixed treatment comparison (MTC) was performed to investigate the relative efficacy and safety of licensed pharmaceuticals for moderate-to-severe restless legs syndrome (RLS).

Tolerability and safety of ropinirole versus other dopamine agonists and levodopa in the treatment of Parkinson's disease: meta-analysis of randomized controlled trials

This review concluded that dopamine agonists, including ropinirole, exhibited a higher incidence of adverse effects than placebo. Ropinirole had a similar profile to other dopamine agonists in terms of adverse events. The level of clinical heterogeneity, reliance on indirect comparisons and the relatively limited search mean that some caution is required in interpreting the conclusions.

Effect of ropinirole on sleep outcomes in patients with restless legs syndrome: meta-analysis of pooled individual patient data from randomized controlled trials

This review concluded that ropinirole improved sleep quantity and adequacy and lessened sleep disturbance and daytime somnolence in patients with moderate to severe primary restless leg syndrome. The authors acknowledged a number of limitations of their review and the conclusions should be treated with some caution.

See all (26)

Summaries for consumers

Options for Treating Restless Legs Syndrome: A Review of the Research for Adults

This summary will cover: What RLS is Treatment options for RLS What researchers have found about RLS treatments

In the later stages of Parkinson's disease, side effects occur because of the use of levodopa treatment.

Three trials have compared ropinirole with an inactive placebo in 263 patients in the later stages of Parkinson's disease. Two studies were relatively small, were conducted over the short term (12 weeks), and used relatively low doses of ropinirole (maximum allowed 8 and 10 mg/d) in a twice daily administration regime. For these reasons, the results of these trials have not been included in a statistical overview. The other study was medium term (26 weeks) and used ropinirole doses in line with the current UK licensed maximum (24 mg/d) in a three times a day regime. The conclusions of this review are based on this single trial and thus should be viewed with some caution.

In the later stages of Parkinson's disease, side effects occur because of the use of levodopa treatment.

Three trials have compared ropinirole with bromocriptine in 482 patients in the later stages of Parkinson's disease. Two studies were conducted over the short term (8 and 16 weeks), and used relatively low doses of ropinirole (9 mg/d) and bromocriptine (17.5 and 22.5mg/d). The other study was medium term (25 weeks) and used ropinirole doses in line with the current UK licensed maximum (24 mg/d).

See all (5)

PubMed Health Blog...

read all...