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Povidone Iodine (Into the eye)

Used to clean your eye and skin before an eye surgery.

What works?

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What works? Research summarized

Evidence reviews

Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone-iodine in clean-contaminated surgery

Preoperative cleansing of the skin with chlorhexidine had significant benefits compared with povidone iodine in reducing postoperative surgical site infections after clean-contaminated surgery. The poor quality of the included studies and some methodological flaws mean that the results should be interpreted with caution and that the reliability of the authors' conclusions is not clear.

Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection

This review found that the intra-operative use of povidone-iodine was associated with reductions in surgical-site infections. Although there was some potential for bias in the conduct of the review and some reporting errors, the authors' conclusions are likely to be reliable.

Systematic review on the effect of rinsing with povidone-iodine during nonsurgical periodontal therapy

BACKGROUND AND OBJECTIVE: The existing literature is inconsistent regarding whether there is any additional effect of povidone-iodine (PVP-iodine) as an adjunctive to scaling and root planing, and, if there is an effect, what its size is. Therefore, the aim of this study was to assess the additional effect of PVP-iodine as an adjunct to scaling and root planing compared with water, saline or no rinse in the treatment of chronic periodontitis.

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Summaries for consumers

Interventions for preventing infectious complications in haemodialysis patients with central venous lines

Patients whose kidneys no longer work need to have water, toxins and other chemicals removed from their blood using an artificial kidney. One method of achieving this is to use a central venous catheter (CVC) which is a small tube inserted via the skin into a blood vessel in the neck of the patient. This tube allows blood to go from the patient, pass through an artificial kidney and return back to the patient. This process is referred to as a dialysis session which takes four hours and is usually performed three times a week. As CVC have direct access to the blood system they can cause serious infections which can be life threatening to the patient. Several strategies can be used to prevent these infections occurring including the application of different types of ointments (mupirocin, povidone‐iodine and polysporin) or medicinal honey to the catheter site, and the use of different dressings which cover the catheter site (transparent or gauze and tape). The review of 10 studies (786 patients) found that mupirocin ointment reduced the risk of patients developing catheter‐related bacteraemia (bacteria in the blood). However, monitoring of mupirocin resistance needs to be considered in future studies. There was not enough evidence to determine which ointment (povidone‐iodine and polysporin) or dressing was the best in preventing infection. There was also insufficient evidence to support the use of medicinal honey for the prevention of infection.

Vaginal cleansing before cesarean delivery to reduce post‐cesarean infections

Cesarean deliveries are very common today, with almost one in three babies born by cesarean in some countries. Antibiotics are routinely given before or during the surgery to reduce the risk of infections, but some women still suffer from these complications. Between one in four and one in 10 women develop an infection of the uterus (endometritis) or a problem with their skin incision, respectively. These complications slow recovery from the surgery and may affect the mother's ability to take care of her baby. Other interventions are needed to further reduce the risk of infections of the uterus and wound problems after cesarean delivery.

Antibiotics and antiseptics to help healing venous leg ulcers

Venous leg ulcers are a type of wound that can take a long time to heal. These ulcers can become infected, and this might cause further delay to healing. Two types of treatment are available to treat infection: systemic antibiotics (i.e. antibiotics taken by mouth or by injection) and topical preparations (i.e. treatments applied directly to the wound). Whether systemic or topical preparations are used, patients will also usually have a wound dressing and bandage over the wound. This review was undertaken to find out whether using antibiotics and antiseptics works better than usual care in healing venous leg ulcers, and if so, to find out which antibiotic and antiseptic preparations are better than others. In terms of topical preparations, some evidence is available to support the use of cadexomer iodine (a topical agent thought to have cleansing and antibacterial effects). Current evidence does not support the use of honey‐ or silver‐based products. Further good quality research is required before definitive conclusions can be drawn about the effectiveness of antibiotic tablets and topical agents such as povidone‐iodine, peroxide‐based products and other topical antibiotics and antiseptics in healing venous leg ulceration.

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