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Phytonadione (Injection)

Prevents bleeding problems by helping blood clot better.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Brand names include
Aquamephyton, Novaplus vitamin K1
Other forms
By mouth
Drug classes About this
Nutritive Agent

What works? Research summarized

Evidence reviews

Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis

This review examined the efficacy of vitamin K in treating excessive anticoagulation. The authors concluded that the limited evidence available suggests that oral or intravenous, but not subcutaneous, vitamin K are more effective than withholding anticoagulation therapy. The methods employed to combine the studies were inappropriate, thus it is impossible to determine whether these conclusions are reliable.

Vitamin K to prevent fractures in older women: systematic review and economic evaluation

This review concluded that, while no recommendations could be made in practice on the use of vitamin K1 to prevent osteoporotic fractures in postmenopausal women, a large randomised controlled trial that compared vitamin K1 with alendronate (bisphosphonate) should be conducted. While there were some concerns over the review process methods, these conclusions appear likely to be reliable.

Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials

This review investigated the effects of oral vitamin K supplements on bone mineral density and fractures. The authors concluded that supplementation may reduce bone loss and that an effect on fractures has been shown in Japanese patients. The cautious conclusions reflect the limitations of the available evidence and appear appropriate.

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