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Naproxen (By mouth)

Treats fever and pain. This medicine is an NSAID.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis) such as inflammation, swelling, stiffness, and joint pain. Naproxen also helps relieve symptoms of ankylosing spondylitis, which is a type of arthritis that affects the joints in the spine. However, this medicine does not cure arthritis and… Read more
Brand names include
Aflaxen, Aleve, Aleve Arthritis, All Day Pain Relief, All Day Relief, Anaprox, Anaprox DS, EC Naprosyn, Flanax Pain Relief Kit, Good Neighbor Pharmacy All Day Pain Relief, Good Sense All Day Pain Relief, Leader All Day Pain Relief, Mediproxen, Naprelan, Naprelan 500, Naprelan Dose Card, NaproPak, NaproPax, Naprosyn, Naxen
Drug classes About this
Analgesic, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults

This review assessed evidence from 1509 participants in 15 randomised, double blind, placebo‐controlled clinical trials of naproxen or naproxen sodium (a non‐steroidal anti‐inflammatory drug) in adults with moderate to severe acute postoperative pain. At doses equivalent to 500 mg and 400 mg, orally administered naproxen provides effective analgesia. About half of those treated experienced at least half pain relief over four to six hours, and the effects lasted, on average, up to nine hours. Associated adverse events did not differ from placebo, but these studies are of limited use for studying adverse effects.

Naproxen for acute migraine in adults

Migraine is a complex condition with a wide variety of symptoms. For many people the main feature is a painful headache. Other symptoms include feeling sick, vomiting, disturbed vision, and sensitivity to light, sound, and smells.

Sumatriptan plus naproxen for acute migraine attacks in adults

The combination of sumatriptan plus naproxen was useful for treating migraine attacks in the studies we found. It was not a lot better than using sumatriptan alone, but it was much better than using naproxen alone. Attacks were more successfully treated when medication was taken early, when pain was mild.

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Summaries for consumers

Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults

This review assessed evidence from 1509 participants in 15 randomised, double blind, placebo‐controlled clinical trials of naproxen or naproxen sodium (a non‐steroidal anti‐inflammatory drug) in adults with moderate to severe acute postoperative pain. At doses equivalent to 500 mg and 400 mg, orally administered naproxen provides effective analgesia. About half of those treated experienced at least half pain relief over four to six hours, and the effects lasted, on average, up to nine hours. Associated adverse events did not differ from placebo, but these studies are of limited use for studying adverse effects.

Naproxen for acute migraine in adults

Migraine is a complex condition with a wide variety of symptoms. For many people the main feature is a painful headache. Other symptoms include feeling sick, vomiting, disturbed vision, and sensitivity to light, sound, and smells.

Sumatriptan plus naproxen for acute migraine attacks in adults

The combination of sumatriptan plus naproxen was useful for treating migraine attacks in the studies we found. It was not a lot better than using sumatriptan alone, but it was much better than using naproxen alone. Attacks were more successfully treated when medication was taken early, when pain was mild.

See all (54)

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