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Liothyronine (Oral route)

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Liothyronine is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It is also used to help decrease the size of enlarged thyroid glands (known as goiter) . Liothyronine is also used in some medical tests to help diagnose problems with the thyroid gland . This medicine is available only with your doctor's prescription … Read more
Brand names include
Cytomel
Other forms
Injection
Drug classes About this
Thyroid Supplement

What works? Research summarized

Evidence reviews

Efficacy and safety of triiodothyronine supplementation in patients with major depressive disorder treated with specific serotonin reuptake inhibitors

The authors said that although there was support for a conclusion that triiodothyronine enhanced and augmented serotonin reuptake inhibitors in major depressive disorder, there was no conclusive evidence. Evidence was limited and the restricted search, lack of reporting of review methods and lack of validity assessment mean that the conclusions may not be reliable.

Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism

The review concluded that thyroxine plus triiodothyronine replacement therapy did not improve well-being, cognitive function, or quality of life compared with thyroxine alone (which may be beneficial in improving psychological or physical well-being). The review's sometimes poor or inconsistent reporting, coupled with the questionable quality of several included trials, indicate that the authors' conclusions should be interpreted with caution.

Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism [Internet]

This report focused on four questions:

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Summaries for consumers

Fact sheet: Understanding thyroid gland tests

The thyroid gland is a vitally important hormonal gland, which mainly works for body’s metabolism. It is located in the front part of the neck below the voice box and is butterfly-shaped. The functions of the thyroid gland include the production of the thyroid hormones triiodothyronine (T3) and tetraiodothyronine, also called thyroxine (T4).

Thyroid hormone supplementation for the prevention of morbidity and mortality in infants undergoing cardiac surgery

There is insufficient evidence to advocate the use of triiodothyronine supplementation for the prevention of postoperative morbidity and mortality in infants who undergo cardiopulmonary bypass.Thyroid hormones are integral in cellular metabolism and haemodynamic stability. A transient acquired hypothyroidism occurs after cardiopulmonary bypass and is thought to be associated with low cardiac output, left ventricular dysfunction, increased vascular resistance and impaired ventilatory drives. Thyroid hormone supplementation has been postulated as a possible therapeutic option to improve postoperative outcome measures. This review highlights the lack of evidence concerning the benefits and harms of triiodothyronine supplementation in infants who undergo cardiopulmonary bypass.

Thyroid hormones for preventing neurodevelopmental impairment in preterm infants

No evidence from trials that thyroid hormone therapy is effective in preventing problems such as respiratory distress syndrome in preterm babies. Thyroid hormones are needed for the normal growth and maturity of the central nervous system, as well as the heart and lungs. Children born without sufficient thyroid hormones can develop serious mental retardation. It is believed that low levels of thyroid hormones in the first few weeks of life (transient hypothyroxinemia) in preterm babies born before 34 weeks may cause this abnormal development. The review of trials found no evidence that using thyroid hormones in preterm babies is effective in reducing the risk of problems caused by insufficient thyroid hormones.

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