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Isosulfan Blue (Injection)

Used during a medical test or imaging procedure to help organs or other body parts show up better.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Isosulfan blue injection is used as an aid in a procedure called lymphography (medical imaging procedure) to test how well your lymphatic system is working in certain parts of your body. It is a blue dye that works by staining the lymph nodes and lymph vessels. This creates a contrast between the lymph nodes and vessels and helps your doctor check for serious medical problems such as lymphedema,… Read more
Brand names include
Lymphazurin, Lymphazurin 1%
Drug classes About this
Diagnostic Agent, Lymphatic Visualization

What works? Research summarized

Evidence reviews

Optimizing Health System Use of Medical Isotopes and Other Imaging Modalities [Internet]

The purpose of this project was to provide national guidance on the optimal use of 99mTc during a situation of reduced supply. To accomplish this, our objective at CADTH was:

Sentinel lymph node status in vulval cancer: systematic reviews of test accuracy and decision-analytic model-based economic evaluation

BACKGROUND: Vulval cancer causes 3-5% of all gynaecological malignancies and requires surgical removal and inguinofemoral lymphadenectomy (IFL). Complications affect > 50% of patients, including groin wound infection, lymphoedema and cellulitis. A sentinel lymph node (SLN) is the first groin node with the highest probability of malignancy. SLN biopsy would be useful if it could accurately identify patients in whom cancer has spread to the groin, without removing all groin nodes. SLNs can be identified by isosulfan blue dye and/or technetium-99 ((99m)Tc) radioactive tracer during lymphoscintigraphy. The blue dye/(99m)Tc procedure only detects SLN, not metastases - this requires histological examination, which can include ultrastaging and staining with conventional haematoxylin and eosin (H&E) or immunohistochemistry.

Is sentinel lymph node mapping in colorectal cancer a future prognostic factor: a meta-analysis

This review assessed the accuracy of sentinel lymph node mapping in colorectal cancer. The review suffered from a number of methodological weaknesses in relation to the literature search, failure to assess study quality, poor reporting of methods of analysis and insufficient investigation of variation between studies. The findings are therefore unlikely to be reliable.

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