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Ibandronate (Injection)

Treats or prevents osteoporosis (weak bones).

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Ibandronate injection is used to treat osteoporosis (thinning of the bone) in women after menopause. This medicine is to be given only by or under the direct supervision of a doctor… Read more
Brand names include
Bondronat, Boniva
Other forms
By mouth
Drug classes About this
Calcium Regulator

What works? Research summarized

Evidence reviews

Ibandronate for the prevention of nonvertebral fractures: a pooled analysis of individual patient data

The authors concluded that higher doses of ibandronate significantly reduced non-vertebral fracture risk in postmenopausal women. A dose-response effect was evident between high and low annual cumulative exposure doses. This individual patient data meta-analysis suffered from potential methodological flaws in the selection of studies and data quality assessment that made the reliability of the authors' conclusion unclear.

Efficacy and safety of monthly 150 mg oral ibandronate in women with postmenopausal osteoporosis: a systematic review and meta-analysis of randomized controlled trials

The authors concluded that monthly ibandronate was comparable in efficacy and safety and was preferred to weekly alendronate. Monthly 150mg ibandronate was superior to daily ibandronate and as well tolerated. Potential for error and bias, clinical differences between studies and the small number of studies available (acknowledged by the authors) mean that the conclusions should be treated with caution.

Closing the Quality Gap: Revisiting the State of the Science (Vol. 4: Medication Adherence Interventions: Comparative Effectiveness)

To assess the effectiveness of patient, provider, and systems interventions (Key Question [KQ] 1) or policy interventions (KQ 2) in improving medication adherence for an array of chronic health conditions. For interventions that are effective in improving adherence, we then assessed their effectiveness in improving health, health care utilization, and adverse events.

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Summaries for consumers

Reducing the Risk of Bone Fracture: A Review of the Research for Adults With Low Bone Density

This summary explains how low bone density can increase the risk of breaking a bone and what research has found about different treatments to lower the risk. It can help you talk with your doctor about which treatment might be right for you.

Osteoporosis Treatments That Help Prevent Broken Bones: A Guide for Women After Menopause

Osteoporosis means that bones become less dense (or less solid). Bones that are less dense are weak and break easier. If your doctor has told you that you have osteoporosis, this guide is for you. It looks at ways to prevent broken bones caused by osteoporosis. It can help you talk to your doctor or nurse about ways to lower your risk of broken bones. It covers: Different kinds of treatments for preventing broken bones from osteoporosis. How well they work. Side effects of osteoporosis medicines. Price.

Bisphosphonates for osteoporosis in primary biliary cirrhosis

Bisphosphonates, such as etidronate, alendronate, ibandronate, are commonly used drugs for treatment of postmenopausal osteoporosis. This review looked at the effect of bisphosphonates for osteoporosis in patients with primary biliary cirrhosis. Six randomised trials, with 200 participants included, provided information for the review. These trials compared etidronate or alendronate with placebo or no intervention; etidronate or alendronate with alendronate or ibandronate; and etidronate with sodium fluoride.

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