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Hydrocodone/Pseudoephedrine (By mouth)

Relieves cough and stuffy nose caused by the common cold. This medicine is a combination of a narcotic cough suppressant and a decongestant.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Hydrocodone and pseudoephedrine combination is used in adults 18 years of age and older to relieve cough and nasal congestion (stuffy nose) caused by the common cold. Hydrocodone is a narcotic antitussive (cough suppressant). It acts directly on the cough center in the brain to relieve cough. Pseudoephedrine is a decongestant, which decreases nasal congestion by narrowing the blood vessels and… Read more
Brand names include
Pancof HC, Rezira
Drug classes About this
Antitussive, Opioid/Decongestant Combination
Combinations including this drug

What works? Research summarized

Evidence reviews

Assessment and Management of Chronic Cough [Internet]

Cough is the most common complaint for patients seeking medical attention in the United States. Although the most common cause of cough is acute self-limited viral infections, chronic cough (cough that lasts more than 4 weeks in children <14 years of age or more than 8 weeks in adolescents and adults) has a significant impact on quality of life and is responsible for up to 38 percent of pulmonary outpatient visits. Furthermore, a treatable cause is absent in up to 46 percent of patients with chronic cough despite a thorough diagnostic investigation. The comparative value of tools for assessing cough and the comparative effectiveness of treatments for unexplained or refractory cough are uncertain.

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