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Fluphenazine Hydrochloride (By mouth)

Treats schizophrenia and different types of behavior problems. Belongs to a class of drugs called phenothiazines.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Other forms
By injection
Drug classes About this
Analgesic, Antipsychotic

What works? Research summarized

Evidence reviews

Oral fluphenazine versus placebo for schizophrenia

Antipsychotic drugs are the first line and mainstay of treatment for schizophrenia. They help to effectively treat psychotic symptoms such as hearing voices and seeing things (hallucinations) and having strange beliefs (delusions). Fluphenazine was one of the first antipsychotics and has been available for around 50 years. Fluphenazine is inexpensive and in developing countries, may be one of the only drug treatments available. In most of Europe and North America, despite still being available, the arrival of newer antipsychotic drugs has reduced the use of fluphenazine and its market share. Fluphenazine has debilitating side effects, including: dizziness; movement disorders such as involuntary movements or spasms; shaking and tremors; inner restlessness and the inability to sit still; and problems with blood pressure, fever and muscle stiffness.

Depot fluphenazine decanoate and enanthate for schizophrenia

People with schizophrenia often hear voices or see things (hallucinations) and have strange beliefs (delusions). The main treatment for these symptoms of schizophrenia are antipsychotic drugs, which can be taken by mouth (tablet) or by an injection (depot). Fluphenazine was one of the first antipsychotic to be produced in depot form. The depot comes in two forms (decanoate and enanthate). Depot injections are often used for people who refuse or forget to take tablets (showing poor compliance or adherence with medication). Fluphenazine is an older antipsychotic drug that is very effective in the treatment of schizophrenia. However, when compared to newer antipsychotic drugs, fluphenazine may have serious side effects (such as involuntary shaking, tremors, muscle stiffness and the inability to sit still) and is known to lower people’s mood.

Comparing effectiveness of an older antipsychotic (oral fluphenazine) with newer antipsychotics for treating schizophrenia

People with schizophrenia often hear voices or see things (hallucinations) and have strange beliefs (delusions). It is a distressing and debilitating illness. The main treatment for schizophrenia is antipsychotic drugs. Fluphenazine is an older antipsychotic drug first formulated in the 1950s, effective for treating the psychoses of schizophrenia. However fluphenazine can cause some serious side effects, particularly movement disorders, and is known to lower people’s mood. Fluphenazine is inexpensive but the arrival of newer antipsychotic drugs with fewer movement disorder side effects reduced its use and market share.

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Summaries for consumers

Oral fluphenazine versus placebo for schizophrenia

Antipsychotic drugs are the first line and mainstay of treatment for schizophrenia. They help to effectively treat psychotic symptoms such as hearing voices and seeing things (hallucinations) and having strange beliefs (delusions). Fluphenazine was one of the first antipsychotics and has been available for around 50 years. Fluphenazine is inexpensive and in developing countries, may be one of the only drug treatments available. In most of Europe and North America, despite still being available, the arrival of newer antipsychotic drugs has reduced the use of fluphenazine and its market share. Fluphenazine has debilitating side effects, including: dizziness; movement disorders such as involuntary movements or spasms; shaking and tremors; inner restlessness and the inability to sit still; and problems with blood pressure, fever and muscle stiffness.

Depot fluphenazine decanoate and enanthate for schizophrenia

People with schizophrenia often hear voices or see things (hallucinations) and have strange beliefs (delusions). The main treatment for these symptoms of schizophrenia are antipsychotic drugs, which can be taken by mouth (tablet) or by an injection (depot). Fluphenazine was one of the first antipsychotic to be produced in depot form. The depot comes in two forms (decanoate and enanthate). Depot injections are often used for people who refuse or forget to take tablets (showing poor compliance or adherence with medication). Fluphenazine is an older antipsychotic drug that is very effective in the treatment of schizophrenia. However, when compared to newer antipsychotic drugs, fluphenazine may have serious side effects (such as involuntary shaking, tremors, muscle stiffness and the inability to sit still) and is known to lower people’s mood.

Comparing effectiveness of an older antipsychotic (oral fluphenazine) with newer antipsychotics for treating schizophrenia

People with schizophrenia often hear voices or see things (hallucinations) and have strange beliefs (delusions). It is a distressing and debilitating illness. The main treatment for schizophrenia is antipsychotic drugs. Fluphenazine is an older antipsychotic drug first formulated in the 1950s, effective for treating the psychoses of schizophrenia. However fluphenazine can cause some serious side effects, particularly movement disorders, and is known to lower people’s mood. Fluphenazine is inexpensive but the arrival of newer antipsychotic drugs with fewer movement disorder side effects reduced its use and market share.

See all (11)

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