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Micromedex DrugNotes [Internet].

Cephapirin (Injection)

Cephapirin (sef-a-PYE-rin)

Published: October 1, 2014.

Treats infections caused by bacteria. Belongs to a class of drugs called cephalosporin antibiotics.

When This Medicine Should Not Be Used

You should not use this medicine if you have ever had an allergic reaction to cephalosporin medicine such as Keflex®, Velosef®, or Ceclor®.

How to Use This Medicine

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given.
  • An IM shot is given in your muscle (upper arm, thigh, buttocks). An IV is medicine that is put directly into your body through one of your veins.
  • This medicine should be given by a person trained to give IV or IM medicine, such as a nurse. Sometimes you, a family member, or friend can be taught to give your medicine.
  • If you are receiving IV medicine, check the bag to make sure there are no leaks. Also make sure the solution is clear.

If a dose is missed:

  • This medicine needs to be given on a regular schedule. Take the missed dose as soon as you remember, and take the rest of the doses for the day at evenly spaced time intervals.
  • If you miss more than one dose, call your doctor for instructions.

How to Store and Dispose of This Medicine:

  • Store in a refrigerator. Do not freeze. Take it out of the refrigerator an hour before the time for your next dose and allow it to warm to room temperature in a clean, dry place.
  • If you see particles in the solution, You should not use it.
  • If you have your treatments at home, you may be given a special container for the used needles. Keep it where children or pets cannot reach it.
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are taking birth control pills or probenecid (Benemid®, ColBENEMID®) while taking cephapirin.

Warnings While Using This Medicine

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Before taking this medicine, let your doctor know if you have ever had an allergic reaction to penicillin medicines.
  • Make sure your doctor knows if you have liver or kidney disease or colitis before taking this medicine.
  • If you have severe diarrhea while taking cephapirin, check with your doctor before taking medicine to stop the diarrhea.
  • Cephapirin may cause incorrect results with urine sugar tests used by patients with diabetes.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Rash, hives, or blistering skin
  • Swelling of the face, throat, or lips
  • Wheezing or trouble breathing
  • Severe diarrhea, vomiting, or stomach pain
  • Pain, burning, or swelling where the shot or IV is given

If you notice these less serious side effects, talk with your doctor:

  • Mild diarrhea
  • Nausea
  • Sore mouth or tongue
  • Vaginal itching or discharge

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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