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Busulfan (By mouth)

Treats certain kinds of leukemia.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

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Antineoplastic Agent

What works? Research summarized

Evidence reviews

Cyclophosphamide plus total body irradiation compared with busulfan plus cyclophosphamide as a conditioning regimen prior to hematopoietic stem cell transplantation in patients with leukemia: a systematic review and meta-analysis

BACKGROUND AND OBJECTIVES: Cyclophosphamide plus total body irradiation (CYTBI) and oral busulfan plus cyclophosphamide (BUCY) are commonly used conditioning regimens prior to allogeneic hematopoietic stem cell transplantation (HSCT) in patients with leukemia. However, there is conflicting data on the superiority of one regimen over the other. Our aim was to critically appraise and synthesize available evidence regarding the efficacy and safety of CYTBI compared to BUCY as a conditioning regimen.

Total body irradiation plus cyclophosphamide versus busulphan with cyclophosphamide as conditioning regimen for patients with leukemia undergoing allogeneic stem cell transplantation: a meta-analysis

The review found that outcomes after allogeneic stem cell transplantation for patients with leukaemia differed according to the conditioning regimen used and the type of leukaemia. Although the review was limited by the small amount of data, variation between studies, lack of randomised evidence and poor reporting of study characteristics, the authors’ cautious conclusion appears likely to be reliable.

Hydroxyurea for the Treatment of Sickle Cell Disease

To synthesize the published literature on the efficacy, effectiveness, and toxicity of hydroxyurea (HU) when used for treatment of sickle cell disease (SCD); and to review the evidence regarding barriers to its use.

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Summaries for consumers

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Expert-reviewed information summary about the health problems that continue or appear after cancer treatment has ended.

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Expert-reviewed information summary about factors that may affect sexual functioning in people with cancer. Fertility issues related to cancer treatment are also discussed.

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