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Alefacept (By injection)

Treats moderate to severe plaque psoriasis. This medicine is an immune suppressant.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Alefacept injection is used to treat chronic plaque psoriasis, which is a skin disease with red and white scales that don't go away. This medicine is given to patients who have used other medicines that did not work well. Alefacept is an immunosuppressant. It works on the immune system to treat the symptoms of plaque psoriasis. This medicine is to be given only by or under the direct supervision of a… Read more
Brand names include
Amevive
Drug classes About this
Immune Suppressant

What works? Research summarized

Evidence reviews

Safety and efficacy of alefacept, efalizumab, etanercept and infliximab in treating moderate to severe plaque psoriasis: a meta-analysis of randomized controlled trials

This review assessed the efficacy and safety of alefacept, efalizumab, etanercept and infliximab for treatment of moderate to severe plaque psoriasis and concluded that all treatments yielded significant improvements over placebo in the short term with an increased risk of adverse events. The authors’ conclusions from this generally well-conducted review reflected the evidence and are likely to be reliable.

Drug Class Review: Targeted Immune Modulators: Final Update 3 Report [Internet]

We systematically compared the efficacy, effectiveness, and safety (adverse events) of abatacept, adalimumab, alefacept, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, natalizumab, rituximab, tocilizumab, and ustekinumab in patients with rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn’s disease, ulcerative colitis, and plaque psoriasis.

Psoriasis: Assessment and Management of Psoriasis

Psoriasis is a common, chronic disease, which for many people, is associated with profound functional, psychological and social morbidity and important comorbidities. Effective treatments are available. Some treatments are expensive; all require appropriate monitoring and some may only be accessed in specialist care settings. Evidence indicates that a substantial proportion of people with psoriasis are currently dissatisfied with their treatment.

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Summaries for consumers

Comparing Targeted Immune Modulators

Targeted immune modulators (also referred to as biologics) form a relatively new class of drugs for diseases with chronic inflammation and an inappropriate immune response. Such diseases include rheumatoid arthritis, psoriasis, and inflammatory bowel diseases.

PubMed Health Blog...

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