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Sodium Polystyrene Sulfonate

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By mouth

Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. This medicine is available only with your… Read more

Brand names include: Kayexalate, Kionex

Rectal

Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. This medicine is available only with your… Read more

Drug classes About this
Exchange Resin

What works? Research summarized

Evidence reviews

Gastrointestinal adverse events with sodium polystyrene sulfonate (kayexalate) use: a systematic review

BACKGROUND: Sodium polystyrene sulfonate (Kayexalate; Sanofi-Aventis, Paris, France) is a cation-exchange resin routinely used in the management of hyperkalemia. However, its use has been associated with colonic necrosis and other fatal gastrointestinal adverse events. Although the addition of sorbitol to sodium polystyrene sulfonate preparations was previously believed to be the cause of gastrointestinal injury, recent reports have suggested that sodium polystyrene sulfonate itself may be toxic. Our objective was to systematically review case reports of adverse gastrointestinal events associated with sodium polystyrene sulfonate use.

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